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| 1 | Hepatic steatosis and fibrosis: Non-invasive assessment显示文摘Chronic liver disease is a major cause of morbidity and mortality worldwide and usually develops over many years, as a result of chronic inflammation and scarring, resulting in end-stage liver disease and its complications. The progression of disease is characterised by ongoing inflammation and consequent fibrosis, although hepatic steatosis is increasingly being recognised as an important pathological feature of disease, rather than being simply an innocent bystander. However, the current gold standard method of quantifying and staging liver disease, histological analysis by liver biopsy, has several limitations and can have associated morbidity and even mortality. Therefore, there is a clear need for safe and noninvasive assessment modalities to determine hepatic steatosis, inflammation and fibrosis. This review covers key mechanisms and the importance of fibrosis and steatosis in the progression of liver disease. We address non-invasive imaging and blood biomarker assessments that can be used as an alternative to information gained on liver biopsy. | Rustam N Karanjia Mary ME Crossey I Jane Cox Haddy KS Fye Ramou Njie Robert D Goldin Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，45： | 6 |
| 2 | Obesity Sleep Annea and Hypertension显示文摘 | Robert W Abu SMS Virend KS | 2003 | Hypertension2003，42，6： | 1 |
| 3 | The effect of a translucent post on resin composite depth of cure显示文摘 | Roberts HW Leonard DL Vandewalle KS | 2004 | Dent Mater2004，20，7： | 1 |
| 4 | Repair of the dura materwith processed collagen devices 显示文摘 | Zerris VA James KS Roberts JB | 2007 | J Biomed Mater Res B ApplBiomater2007，83，2： | 1 |
| 5 | FEVj/FVCratio of 70% misclassifies patients with obstruction at theextremes of age 显示文摘 | Roberts SD Farber MO Knox KS | 2006 | Chest2006，1，： | 1 |
| 6 | Antigen-specific cytolysis by neutrophils and NK ceils expressing chimeric immune receptors bearing zeta or gamma signaling domains 显示文摘 | Roberts MR Cooke KS Tran AC | 1998 | J Immunol1998，161，1： | 1 |
| 7 | Persistent angina pectorisinischaemic cardiomyopathy :increased rehospitalization and majoradverse cardiac events 显示文摘 | Robert JM Samuel B Linda KS | 2014 | European Journal of Heart Failure2014，16，8： | 1 |
| 8 | The impact of leiomyomas on pregnancy显示文摘 | Roberts WE Fulp KS Morrison JC | 1999 | Aust N Z J Obstet Gynaecol1999，39，1： | 1 |
| 9 | Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices显示文摘 | Angeka CE Robert KS Shih-Chieh C | 2002 | J Neurophysiol2002，88，4： | 1 |
| 10 | The impact of leiomyoma on pognancy显示文摘 | Robert WE Fulp KS Momoon JC | 1999 | Obstet Gynaecol1999，39，1： | 1 |
| 11 | Power distribu- tion across the face of different light guides and its effect on com- posite surface microhardness 显示文摘 | Vandewalle KS Roberts HW Rueggeberg FA | 2008 | J Esther Restor Dent2008，20，2： | 1 |
| 12 | Induction of CP2E1 in liver,kidney,brain and intestine during chronic ethanol ad- ministration and withdrawals evidence that CYP2E1 posses- ses a rapid phase hail--life of 6 hours or less显示文摘 | Roberts BJ Shoal SE Jeong KS | 1994 | Bioehem Biophys Res Commun1994，205，： | 1 |
| 13 | Serum Immunoreactive-leptin concentration in normal-weight and obese humans 显示文摘 | Robert VC Madhur KS Mark LH | 1996 | N Engl J Med1996，334，5： | 1 |
| 14 | Outbreaks of renal failure associated with melamine and cyanuric acid in dogs and cats in 2004 and 2007显示文摘 | Brown CA Jeong KS Robert H el al | 2007 | J Vel Diagn Invest2007，19，5： | 1 |
| 15 | Role of Synaptic Metabotropic Glutamate Receptors in Epileptiform Discharges in Hippocampal Slices显示文摘 | Angela CE Robert KS Shih-Chieh C | 2002 | J Neurophysiol2002，88，4： | 1 |
| 16 | Persistent angina pectorisin ischaemic cardiomyopathy : increased rehospitalization and majoradverse cardiac events 显示文摘 | Robert JM Samuel B Linda KS | 2014 | European Journal of Heart Failure2014，6，8： | 1 |
| 17 | Tumor-associated peripheral eosionophilia: two unusual cases 显示文摘 | Sethu KS Reddy Robert H | 1984 | J Clin Oncolo1984，2，10： | 1 |
| 18 | The effect of a translucent post on resin composite depth of cure 显示文摘 | Roberts HW Leonard DL Vanderwalle KS | 2004 | Dent Mater2004，20，7： | 1 |
| 19 | Guiding the selection of human antibodies from phage display repertoires to a single epltope of an antigen显示文摘 | Jespers KS Roberts A Mahler SM | 1994 | Bio Technology1994，12，9： | 1 |
| 20 | A three-dimensional osteochondral composite scaffold for articular cartilage repair显示文摘 | Jill KS Susan L Robert P | 2002 | Biomater- ials2002，230，1： | 1 |
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