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| 1 | Different characteristics of chronic dibutyltin dichloride-induced pancreatitis and cholangitis in mouse and rat显示文摘Background:Current animal models of chronic pancreatitis(CP)often provide only limited pathophysio-logical insights since they incompletely reflect the human disease.CP induced by injection of dibutyltin dichloride(DBTC-pancreatitis)shares with human CP the important feature of extended fibrosis and would be an even more attractive model if it could be transferred from rats to mice,as recently sug-gested in the context of combined ethanol and DBTC application.This study aimed to evaluate the effects of DBTC in pancreas and liver of C57BL/6 mice,a strain commonly used to engineer genetic mouse mod-els.Methods:C57BL/6 mice and Lewis rats were exposed to variable doses of DBTC.After an investigation period of up to 4 weeks,laboratory findings and histopathological changes of pancreas and liver were evaluated.Results:Chronic DBTC-pancreatitis in rats was characterized by acinar cell damage,ductal changes,fi-brosis,and inflammatory cell infiltrates.Mice treated with DBTC at 6–8 mg/kg body weight,the standard doses in rats,showed transient increases of lipase activities but no morphological signs of chronic DBTC-pancreatitis 4 weeks after injection of the drug.Increased doses of 10–12 mg/kg DBTC were intolerable due to their high toxicity.In contrast,mice and rats presented with a similar histopathology of the liver that can be characterized as a chronic-proliferative DBTC-cholangitis with predominating damage and proliferation of the small bile ducts as well as secondary portal inflammatory cell infiltrates and a begin-ning portal fibrosis.Conclusions:The DBTC-model cannot be transferred from rats to C57BL/6 mice with respect to chronic DBTC-pancreatitis,but might be of interest to study DBTC-cholangitis in both species. | Friederike Lütt Luise Ehlers Horst Nizze Robert Jaster | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，2： | 2 |
| 2 | A comparison Of Entecavir and Lamivudine for HBeAg- positive chronic hepatitis B 显示文摘 | Chang TT Robeft GG Robert M | 2006 | N Engl J Med2006，354，10： | 1 |
| 3 | mRNA display:ligand discovery,interaction analysis and beyond显示文摘 | Austin RJ Roberts RW | 2003 | Trends in Biochemical Sciences2003，28，3： | 1 |
| 4 | Scanometric DNA Array Detection with Nanoparticle Probes显示文摘 | Andrew TT Chad AM Robert LL | 2000 | Science2000，289，： | 1 |
| 5 | A comparison of Entecavir and Lamivudine for HBeAg-positive chronic hepatitis B显示文摘 | Chang TT Robeft GG Robert M | 2006 | N Engl J Meal2006，354，10： | 1 |
| 6 | Sonographic appearance of pri- mary synovial chondromatosis of the knee显示文摘 | Roberts D Miller TT Erlanger SM | 2004 | Utrasound Med2004，23，5： | 1 |
| 7 | Human MDR1 protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts显示文摘 | Roberts WK Ling TT | 1997 | Biochemistry1997，36，11： | 1 |
| 8 | Preservation of striatal tissue and behavioral function after neural stem cell transplantation in a rat model of Huntington's disease显示文摘 | Roberts TT Price J Williams SC | | 0，，04： | 1 |
| 9 | Sonographie appearance of primary synovial chondromatosis of the knee显示文摘 | Roberts D Miller TT Erlanger SM | 2004 | J Ultrasound Med2004，23，5： | 1 |
| 10 | Low risk of thromboembolic complications with tranexamic acid after primary total hip and knee arthroplasty显示文摘 | Blake PG Lori JD Robert TT | 2013 | Clin Orthop2013，471，2： | 1 |
| 11 | Linking antibody Fc domain to endostatin significantly improves endostatin half-life and efficacy显示文摘 | Lee TY Robert M Sjin TT | 2008 | Clin Cancer Res2008，14，5： | 1 |
| 12 | Detection of patients with coronary artery disease using cardiac magnetic field mapping at rest显示文摘 | Andrej Gapelyuk Niels Wessel Robert Fischer Udo Zacharzowsky Lydia Koch Daniela Selbig Henry Schütt Bianca Sawitzki Friedrich C. Luft Rainer Dietz Alexander Schirdewan | 2007 | Journal of Electrocardiology2007，，5： | 1 |
| 13 | A comparison of Entecavir and hamivudine for HBeAg-positiVe chroniC hepatitis B显示文摘 | Chang TT Robert GG Robert M | 2006 | N Engl J Meal2006，354，10： | 1 |
| 14 | ()steogenesis imperfecta: primary care显示文摘 | Starr SR Roberts TT Fischer PR | 2010 | Pediatr Rev2010，31，： | 1 |
| 15 | A comparison of Entecavir and Lamivudine for HBeAg-positive chronic hepatitis B 显示文摘 | Chang TT Robeft GG Robert M | 2006 | N Engl J Meal2006，354，10： | 1 |
| 16 | Osteogenesis imperfecta: pri- mary care 显示文摘 | Starr SR Roberts TT Fischer PR | 2010 | Pediatr Rev2010，31，8： | 1 |
| 17 | mRNA display:ligand discovery,interaction analysis and beyond显示文摘 | Takahashi TT Austin RJ Roberts RW | 2003 | Trends Biochemical Sci2003，28，3： | 1 |
| 18 | Diagnosis and management of Langer- hans cell histiocytosis显示文摘 | DiCaprio MR Roberts TT | 2014 | J Am Acad Orthop Surg2014，22，10： | 1 |
| 19 | Allergen specific lgE, number and timing of past suicide attempts, and instability in patients with recurrent mood disorders 显示文摘 | Postolache TT Roberts DW Langenberg P | 2008 | Int J Child Health Hum Dev2008，1，3： | 1 |
| 20 | Osteogenesis imperfecta:primary care显示文摘 | Starr SR Roberts TT Fischer PR | 2010 | Pediatr Rev2010，31，8： | 1 |
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