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| 1 | 胸腔镜肺叶切除术显示文摘背景与目的:尽管14年前我们就已报道在胸腔镜下可完成解剖意义上彻底的肺叶切除和淋巴结清扫,但关于这一术式的争论以及胸外科医师们提出的如何完成这种手术的疑问,使这种术式的被接受程度受到了限制。随着对这一术式持支持态度的人不断增多,这一术式的开展也越来越广泛。本文将讨论该术式的手术技术,临床疗效,以及关于这种术式的各种争论。方法:1992—2005年间我们共进行胸腔镜肺叶切除术1315例,其中女性700例(53.2%),男性615例(46.8%),患者平均年龄71.2岁。患者术后病理诊断:良性病变53例,肺部转移性肿瘤28例,淋巴瘤5例,肺癌1015例。腺癌在原发性肺癌中占63.1%。解剖意义上彻底的肺门切除和淋巴结活检或清扫均通过观察监视器屏幕完成,切口长约5cm,不需撑开肋骨。结果:9例(0.8%)死亡(无术中死亡及出血死亡患者)。932例(84.7%)术后没有出现并发症。1100例患者中有45例(4.1%)需输血。中位住院时间3d,平均住院时间4.78d。180例(20%)患者于术后第1天或第2天出院。28例(2.5%)患者术中转为开胸手术。5例(0.57%)患者术后切口出现复发。其中2003年内,在224例肺叶切除中89%通过胸腔镜完成。结论:在胸腔镜下可完成解剖意义上彻底的肺叶切除,且并发症率和死亡率较低。术中出血及切口复发的风险很小。 | Robert J McKenna Ward Houck 罗晓阳 | 2006 | 中国癌症杂志2006，16，8： | 20 |
| 2 | Increased hepcidin expression in colorectal carcinogenesis显示文摘AIM:To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anae- mia and whether it might have a role in colorectal car- cinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using im- munohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was posi- tively associated with increasing T-stage of colorectal cancer (P < 0.05). Furthermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repres- sion. This was supported by hepcidin immunoreactivity in colorectal cancer tissue. CONCLUSION: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism. | Douglas G Ward Keith Roberts Matthew J Brookes Howard Joy Ashley Martin Tariq Ismail Robert Spychal Tariq Iqbal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 3 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 4 | IMMEDIATE AND POSTOPERATIVE COMPLICATIONS OF TRANSURETHRAL PROSTATECTOMY IN THE 1990s显示文摘 | PRODROMOS G. BORBOROGLU CHRISTOPHER J. KANE JOHN F. WARD JAMES L. ROBERTS JOHN P. SANDS | 1999 | The Journal of Urology1999，，4： | 5 |
| 5 | Video-Assisted Thoracic Surgery Lobectomy: Experience With 1,100 Cases显示文摘 | Robert J. McKenna Ward Houck Clark Beeman Fuller | 2006 | The Annals of Thoracic Surgery2006，，2： | 3 |
| 6 | Reinventing residual reserves in the sea: are we favouring ease of establishment over need for protection?显示文摘 | Rodolphe Devillers Robert L. Pressey Alana Grech John N. Kittinger Graham J. Edgar Trevor Ward Reg Watson | 2015 | Aquatic Conserv: Mar. Freshw. Ecosyst2015，，4： | 1 |
| 7 | Modeling the effect of nonpenetrating ballistic impact as a means of detecting behind-armor blunt trauma显示文摘 | Roberts JC O'ConnorJV Ward EE | | 0，，06： | 1 |
| 8 | Patron-driven acquisitions: an introduction and literature review显示文摘 | Judith M Nixon Robert S Freeman Suzanne M Ward | 2010 | Collection Management2010，，35： | 1 |
| 9 | Inorganic chloramines as drinking water disinfectants:a review显示文摘 | Wolfe N Robert Ward | 1984 | J American Water Works Association1984，76，5： | 1 |
| 10 | Cost-effectiveness of botulinum toxin type a in the treatment of post-stroke spasticity 显示文摘 | Ward A Roberts G Warner J et a/ | 2005 | JRehabil Med2005，37，4： | 1 |
| 11 | The Crystal Structure of a Truncated ErbB2 Ectodomain Reveals an Active Conformation, Poised to Interact with Other ErbB Receptors显示文摘 | Thomas P.J. Garrett Neil M. McKern Meizhen Lou Thomas C. Elleman Timothy E. Adams George O. Lovrecz Michael Kofler Robert N. Jorissen Edouard C. Nice Antony W. Burgess Colin W. Ward | 2003 | Molecular Cell2003，，2： | 1 |
| 12 | Epithelial invasion and cell lysis by virulent strains of Streptococcus suis is enhanced by the presence of suilysin显示文摘 | Pamela M Norton Charlotte Rolph Philip N Ward Robert W Bentley James A Leigh | 1999 | FEMS Immunology and Medical Microbiology1999，，1： | 1 |
| 13 | Bone and muscle geometry in the prepubertal skeleton显示文摘 | Ward K Adams J Roberts S | 2004 | Arch Dis Child2004，89，： | 1 |
| 14 | Modeling the effect of non-penetrating ballistic impact as a means of detecting behind armor blunt trauma 显示文摘 | Roberts JC Ward EE O' Connor JV | 2005 | J Trauma2005，58，6： | 1 |
| 15 | Advanced Reproductive Age and Fertility显示文摘 | Kimberly Liu Allison Case Anthony P. Cheung Sony Sierra Saleh AlAsiri Belina Carranza-Mamane Allison Case Cathie Dwyer James Graham Jon Havelock Robert Hemmings Francis Lee Kimberly Liu Ward Murdock Vyta Senikas Tannys D.R. Vause Benjamin Chee-Man Wong | 2011 | International Journal of Gynecology and Obstetrics2011，，1： | 1 |
| 16 | Pelvic Fracture from Major Blunt Trauma Outcome Is Determined by Associated Injuries显示文摘 | GALEN V. POOLE E. FRAZIER WARD FARID F. MUAKKASSA HENRY S. H. HSU JOHN A. GRISWOLD ROBERT S. RHODES | 1991 | Annals of Surgery1991，，6： | 1 |
| 17 | Team performance: The case of english premiership football 显示文摘 | FIONA CARMICHAEL DENNIS THOMAS ROBERT WARD | 2000 | Manag Decision Eco2000，21，1： | 1 |
| 18 | Video-Assisted Thoracic Surgery Lobectomy: Experience with 1,100 Cases 显示文摘 | Robert J Mckenna JR Ward Houck | 2006 | Ann Thorac Surg2006，81，2： | 1 |
| 19 | Membrane and cytoplasmic proteins are transported in the same organelle complex during nematode spermatogenesis显示文摘 | Roberts TM Pavalko FM Ward S | 1986 | J Cell Biology1986，102，： | 1 |
| 20 | New approaches to the minimally invasive treatment of lung cancer显示文摘 | Robert J Jr Houck Ward V | 2005 | Current Opinion in Pulmonary Medicine2005，11，4： | 1 |
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