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| 1 | Metabolomics characterization of colostrum in three sow breeds and its influences on piglets' survival and litter growth rates显示文摘Background: Colostrum is the first secretion produced by mammary glands during the hours immediately preceding and succeeding parturition. This secretion differs from milk and represents an essential vehicle of passive immunity,prebiotic compounds and growth factors involved in intestinal development. Most of the literature concerning colostrum composition refers mainly to human and cow; and little is known about pig colostrum metabolome and how it varies between pig breeds and different farrowing parity. Thus, the aim of the present research is to provide new information about pig colostrum composition and the associations between metabolites, the sows' breed and the survival and growth rates of their litters.Results: Colostrum samples were gathered from 58 parturitions of sows belonging to three different breeds chosen for their importance in Italian heavy pig production: 31 Large White, 15 Landrace and 12 Duroc respectively. The defatted and ultrafiltered colostrum samples were analysed using1 H–NMR spectroscopy. Principal Components Analysis(PCA) was assessed on the obtained spectra. In addition, using a Stepwise Regression and a Linear Regression analyses the metabolites named after the signals assignment were tested for their associations with piglets' performances.Twenty-five metabolites were identified, comprehending monosaccharides, disaccharides(such as lactose), organic acids(lactate, citrate, acetate and formate), nitrogenous organic acids(such as creatine) and other compounds,including nucleotides. PCA results evidence a clustering due to breed and season effects. Lactose was the main compound determining the assignment of the samples into different clusters according to the sow breed. Furthermore, some metabolites showed to be associated with piglets' performance and survival traits: acetate and taurine were positively related to litter weight gain and piglets' survival rate, respectively, while dimethylamine and cis-aconitate were linked to new-borns' impaired ability to survive.Conclusions: The results obtained suggest that colostrum composition is affected by breed, which, together with environmental conditions, may cause changes in colostrum metabolites content with possible consequences on piglets' performances. Among the identified metabolites, acetate, taurine, dimethylamine and cis-aconitate showed consistent associations with piglets' survival rate and litter weight gain, implying that these compounds may affect new-borns' ability to survive. | Gianfranco Picone Martina Zappaterra Diana Luise Alessia Trimigno Francesco Capozzi Vincenzo Motta Roberta Davoli Leonardo Nanni Costa Paolo Bosi Paolo Trevisi | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 6 |
| 2 | Search for naive human pluripotent stem cells显示文摘Normal mouse pluripotent stem cells were originally derived from the inner cell mass(ICM) of blastocysts and shown to be the in vitro equivalent of those pre-implantation embryonic cells, and thus were called embryonic stem cells(ESCs). More than a decade later, pluripotent cells were isolated from the ICM of human blastocysts. Despite being called human ESCs, these cells differ significantly from mouse ESCs, including different morphology and mechanisms of control of pluripotency, suggesting distinct embryonic origins of ESCs from the two species. Subsequently, mouse pluripotent stem cells were established from the ICMderived epiblast of post-implantation embryos. These mouse epiblast stem cells(Epi SCs) are morphological and epigenetically more similar to human ESCs. This raised the question of whether cells from the human ICM are in a more advanced differentiation stage than their murine counterpart, or whether the available culture conditions were not adequate to maintain those human cells in their in vivo state, leading to a transition into Epi SC-like cells in vitro. More recently, novel culture conditions allowed the conversion of human ESCs into mouse ESC-like cells called nave(or ground state) human ESCs, and the derivation of nave human ESCs from blastocysts. Here we will review the characteristics of each type of pluripotent stem cells, how(and whether) these relate to different stages of embryonic development, and discuss the potential implications of nave human ESCs in research and therapy. | Simone Aparecida Siqueira Fonseca Roberta Montero Costas Lygia Veiga Pereira | 2015 | World Journal of Stem Cells2015，7，3： | 2 |
| 3 | Circulating miR-29a, Among Other Up-Regulated MicroRNAs, Is the Only Biomarker for Both Hypertrophy and Fibrosis in Patients With Hypertrophic Cardiomyopathy显示文摘 | Roberta Roncarati Chiara Viviani Anselmi Maria Angela Losi Laura Papa Elena Cavarretta Paula Da Costa Martins Carla Contaldi Gloria Saccani Jotti Anna Franzone Laura Galastri Michael V.G. Latronico Massimo Imbriaco Giovanni Esposito Leon De Windt Sandro B | 2014 | Journal of the American College of Cardiology2014，，9： | 2 |
| 4 | Height-to-diameter ratios with temporal and dendro/morphometric variables for Brazilian pine in south Brazil显示文摘Height-to-diameter ratios(HD)are an important measure of the stability,density and competition of forest stands.It refl ects the vertical growth of the trees,the vulnerability of the forest canopy structure and infl uences volumetric production.HD ratios vary according to tree size,availability of resources for growth,stand density and species composition.Data were taken from 210 trees and a regression technique of generalized linear models for the HD ratio applicable for forest structure conservation was developed.The objective of this study was to model the HD ratios of dominant and co-dominant trees of Araucaria angustifolia according to morphometric,dendrometric,annual diameter increment,stand density,and age variables in three sites in southern Brazil.The results show that the HD ratio decreases with increasing age,crown area and basal area,and increases with stand density and annual diameter increment.Accuracy of the developed equations was demonstrated by the values of deviation,Bayesian and Akaike criteria.The results are of interest to forest managers since they make decisions about silvicultural operations.Growth continuity and forest production indicate that any intervention should be directed at younger trees of smaller sizes,and that one of the main management factors for stand stability and growth is the formation of the stand and its capture of light. | Andre Felipe Hess Myrcia Minatti Emanuel Arnoni Costa Luis Paulo Baldissera Schorr Gabriel Teixeira da Rosa Isadora de Arruda Souza Geedre Adriano Borsoi Veraldo Liesenberg Thiago Floriani Stepka Roberta Abatti | 2021 | Journal of Forestry Research2021，32，1： | 2 |
| 5 | An AHP approach to assess brand intangible assets 显示文摘 | Roberta Costa Simonluea Evangelista | 2008 | Measuring Business Excellence2008，12，2： | 1 |
| 6 | Twelve-year experience with left atrial resection in the treatment of non-small cell lung cancer显示文摘 | Giovanni B Ratto Roberta Costa Giuseppe Vassallo | 2004 | Ann Thorac Surg2004，78，： | 1 |
| 7 | Noninvasive vs invasive ventilation in COPD patients with severe acute respiratory failure deemed to require ventilatory assistance显示文摘 | Enzo Squadrone Pamela Frigerio Claudio Fogliati Cesare Gregoretti Giorgio Conti Massimo Antonelli Roberta Costa Paola Baiardi Paolo Navalesi | 2004 | Intensive Care Medicine2004，，7： | 1 |
| 8 | Orbital myositis: Diagnosis and management显示文摘 | Roberta M. S. Costa Oana M. Dumitrascu Lynn K. Gordon | 2009 | Current Allergy and Asthma Reports2009，，4： | 1 |
| 9 | Twelve-year experience with left atrial resection in the treatment of non–small cell lung cancer显示文摘 | Giovanni B Ratto Roberta Costa Giuseppe Vassallo Antonella Alloisio Paola Maineri Paolo Bruzzi | 2004 | The Annals of Thoracic Surgery2004，，1： | 1 |
| 10 | Long-term safety of anti-TNF-α in PsA patients with concomitant HCV infection: a retrospective observational multicenter study on 15 patients显示文摘 | Luisa Costa Francesco Caso Mariangela Atteno Chiara Giannitti Antonio Spadaro Roberta Ramonda Maristella Vezzù Antonio Puente Filomena Morisco Ugo Fiocco Mauro Galeazzi Leonardo Punzi Raffaele Scarpa | 2014 | Clinical Rheumatology2014，，2： | 1 |
| 11 | Molecular identification of nontuberculous mycobacteria isolates in a Brazilian mycobacteria reference laboratory显示文摘 | Ana Roberta Fusco da Costa Maria Luiza Lopes Ismari Perini Furlaneto Maísa Silva de Sousa Karla Valéria Batista Lima | 2010 | Diagnostic Microbiology & Infectious Disease2010，，4： | 1 |
| 12 | Investigating the potential of functionalized MCM-41 on adsorption of Remazol Red dye显示文摘 | Danilo Oliveira Santos Maria Lourdes Nascimento Santos José Arnaldo Santana Costa Roberta Anjos Jesus Sandro Navickiene Eliana Midori Sussuchi Maria Eliane Mesquita | 2013 | Environmental Science and Pollution Research2013，，7： | 1 |
| 13 | Hydrogenation of synthetic PYGAS- effects of zirconia on Pd/AI203 显示文摘 | Alexandre Barros Gaspar Gabriel Rosa dos Santos Roberta de Souza Costa | 2008 | Catalysis Today2008，，133135： | 1 |
| 14 | Using Fuzzy AHP to manage Intellectual Capital assets: An applicationto the ICT service industry 显示文摘 | Armando Calabrese Roberta Costa Tamara Menichini | 2013 | Expert Systems with Applications2013，，40： | 1 |
| 15 | Latent tuberculosis:Risk factors,screening and treatment in liver transplantation recipients from an endemic area显示文摘BACKGROUND Patients undergoing solid organ transplantation,particularly those who live or have lived in tuberculosis(TB)endemic areas,are at a high risk of developing TB.The majority of post-transplantation TB cases are associated with reactivation of latent TB infection(LTBI).Brazil is in a single position with overlapping areas of high TB endemicity and high transplant activity.In liver transplant(LT),one should be aware of the potential hepatotoxicity associated with the treatment regimens for LTBI.AIM To evaluate the frequency of LTBI in LT patients and treatment-related issues.METHODS This was a retrospective analysis of a cohort of cirrhotic patients aged≥18 years,who underwent LT at a high-complexity teaching hospital from January 2005 to December 2012.RESULTS Overall,429 patients underwent LT during the study period.Of these,213(49.7%)underwent the tuberculin skin test(TST)during the pre-transplant period,and 35(16.4%)of them had a positive result.The treatment for LTBI was initiated after LT in 12(34.3%)of the TST-positive patients;in 3(25.0%),treatment was maintained for at least 6 mo.CONCLUSION The prevalence of LTBI was lower than expected.Initiation and completion of LTBI treatment was limited by difficulties in the management of these special patients. | Isabela Dias Lauar Luciana Costa Faria Roberta Maia de Castro Romanelli Wanessa Trindade Clemente | 2021 | World Journal of Transplantation2021，11，12： | 1 |
| 16 | Using fuzzy AHP to manage intellectual capital assets : An appli- cation to the ICT service industry显示文摘 | Armando Calabrese Roberta Costa Tamara Menichini | 2013 | Expert Systems with Applications2013，40，9： | 1 |
| 17 | Noninvasive vs invasive ventilation in COPD patients with severe acute respiratory failure deemed to require ventilatory assistance显示文摘 | Enzo Squadrone Pamela Frigerio Claudio Fogliati Cesare Gregoretti Giorgio Conti Massimo Antonelli Roberta Costa Paola Baiardi Paolo Navalesi | 2004 | Intensive Care Medicine2004，，7： | 1 |
| 18 | Using Fuzzy AHP to manage Intellectual Capital assets: An application to the ICT service industry显示文摘 | Armando Calabrese Roberta Costa Tamara Menichini | 2012 | Expert Systems With Applications2012，，： | 1 |
| 19 | Technological development in mechanical ventilation显示文摘 | Giorgio Conti Roberta Costa | 2010 | Current Opinion in Critical Care2010，16，： | 1 |
| 20 | Metabolomics in cancer and cancer-associated inflammatory cells显示文摘Metabolomics is the last frontier of modern molecular biology,and the state-of-the-art technique for studying metabolism.Mass spectrometry and nuclear magnetic resonance spectroscopy are the main analytical approaches in metabolomics.Cellular metabolism plays a pivotal role during cell resting and activation.Immune cells exhibit remarkable metabolic plasticity,fundamental to support their adaptation to inflammatory environments and functional requirements.Cancer is a metabolic and inflammatory disease.A metabolic shift is crucial for oncogenesis,tumor cell survival,invasion,metastasis,and the associated inflammatory process.The tumor microenvironment is mainly orchestrated by immune-inflammatory cells and essential for the neoplastic process.Inflammatory cells from tumor stroma adapt to different metabolic pathways during tumor progression,and this metabolic reprogramming affects macrophages,neutrophils,T cells,and others.Targeting the metabolism of tumor and immune cells may lead to important therapeutic implications in cancer.Thus,understanding the metabolic changes that drive the interactions between tumor and stromal cells is a promising avenue advances in cancer diagnostics and therapies,leading to more accurate guidance.In this review,we discuss the most recent metabolomics approaches in cancer studies on the tumor-associated inflammatory microenvironment. | Gilson Costa dos Santos Roberta Saldanha-Gama Natália Mesquita de Brito Mariana Renovato-Martins Christina Barja-Fidalgo | 2021 | Journal of Cancer Metastasis and Treatment2021，7，1： | 0 |
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