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| 1 | Complement activation by phospholipids: the interplay of factor H and C1q显示文摘Complement proteins in blood recognize charged particles.The anionic phospholipid(aPL)cardiolipin binds both complement proteins C1q and factor H.C1q is an activator of the complement classical pathway,while factor H is an inhibitor of the alternative pathway.To examine opposing effects of C1q and factor H on complement activation by aPL,we surveyed C1q and factor H binding,and complement activation by aPL,either coated on microtitre plates or in liposomes.Both C1q and factor H bound to all aPL tested,and competed directly with each other for binding.All the aPL activated the complement classical pathway,but negligibly the alternative pathway,consistent with accepted roles of C1q and factor H.However,in this system,factor H,by competing directly with C1q for binding to aPL,acts as a direct regulator of the complement classical pathway.This regulatory mechanism is distinct from its action on the alternative pathway.Regulation of classical pathway activation by factor H was confirmed by measuring C4 activation by aPL in human sera in which the C1q:factor H molar ratio was adjusted over a wide range.Thus factor H,which is regarded as a down-regulator only of the alternative pathway,has a distinct role in downregulating activation of the classical complement pathway by aPL.A factor H homologue,β2-glycoprotein-1,also strongly inhibits C1q binding to cardiolipin.Recombinant globular domains of C1q A,B and C chains bound aPL similarly to native C1q,confirming that C1q binds aPL via its globular heads. | Lee Aun Tan Bingbin Yu Francis CJ Sim Uday Kishore Robert B Sim | 2010 | Protein & Cell2010，1，11： | 2 |
| 2 | Repression of p53-mediated Transcription by MDM2: a Dual Mechanism显示文摘 | Coodrich JA Robert Tijan | 1997 | Genes Dev1997，11，15： | 1 |
| 3 | Targeting the Raf - MEK - ERK mitogen- activated protein kinase cascade for the treat- ment of cancer 显示文摘 | Roberts PJ Der CJ | 2007 | Oncogene2007，26，22： | 1 |
| 4 | The action of seven convulsants as antagonists of the GABA response of Limulus neurons 显示文摘 | Roberts CJ James VA Collins JF | 1981 | Comp Biochem Physiol C1981，70，： | 1 |
| 5 | The action of seven convulsants as antagonists of the GABA response of limulus neurons 显示文摘 | Roberts CJ James VA CoUins | 1981 | Compar- ative Biochemistry and Physiology1981，，70： | 1 |
| 6 | Cold machine perfusion versus static cold storage of kidneys donated after cardiac death : a UK muhicenter randomized controlled trial显示文摘 | Watson CJ Wells AC Roberts RJ | 2010 | Am J Transplant2010，10，9： | 1 |
| 7 | CDK inhibitois: positive and negative regulators of Gl-phase progression 显示文摘 | Sherr CJ Roberts JM | 1999 | Genes Dev1999，13，12： | 1 |
| 8 | Rigid implant anchorage to close a mandibular first molar extraction site 显示文摘 | Roberts WE Nelson CL Goodaere CJ | 1994 | J Clin Orthod1994，28，： | 1 |
| 9 | Posterior corneal surface changes after laser in situ keratomileusis显示文摘 | Bruno CR Roberts CJ Castellano D | 2001 | Invest Ophthalmol Vis Sci2001，42，4： | 1 |
| 10 | Living with or without cyclins and cyclin-dependent Kinases显示文摘 | Sherr CJ Roberts JM | 2004 | Genes Dev2004，18，22： | 1 |
| 11 | Living with or without cyclins and cyclin- dependent kinases 显示文摘 | Sherr CJ Roberts JM | 2004 | Genes Dev2004，18，22： | 1 |
| 12 | Prosthodontic considerations when using implants for orthodontic anchorage 显示文摘 | Goodacre CJ Brown DT Roberts WE | 1997 | J Prosthet Dent1997，77，： | 1 |
| 13 | CDK inhibitors:positive and negative regulators of G1-phase progression显示文摘 | Sherr CJ Roberts JM | 1999 | Genes Dev1999，13，12： | 1 |
| 14 | p27kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest 显示文摘 | Kato JY Solomon MJ Sherr CJ Massague J Roberts JM | 1994 | Genes Dev1994，78，： | 1 |
| 15 | Natural history of prostatism: risk factors for acute urinary retention显示文摘 | Jacobsen SJ Girman CJ Roberts RO etal | 1997 | J Urol1997，158，2： | 1 |
| 16 | Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer显示文摘 | Roberts PJ Der CJ | 2007 | Oncogene2007，26，14： | 1 |
| 17 | Changes in corneal biomechanics and intraocular pressure following LASIK using static,dynamic,and noncontact tonometry显示文摘 | Pepose JS Feigenbaum SK Qazi MA Sanderson JP Roberts CJ | 2007 | Am J Ophthalmol2007，143，： | 1 |
| 18 | The antiemetic effectiveness of droperidol during morphine patient controlled analgesia 显示文摘 | Roberts CJ Millar JM | 1995 | Anaesthesia1995，50，： | 1 |
| 19 | CDK inhibitors: positive and negative regulators of G1-phase progression显示文摘 | Sherr CJ Roberts JM | 1999 | Genes Dev1999，13，12： | 1 |
| 20 | Inhibitors of mammalian G1 cyclin-dependent kinases显示文摘 | Sherr CJ Roberts JM | 1995 | Genes Dev1995，9，10： | 1 |
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