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    题名 作者 年代 出处 被引量
1Oxidative stress and male reproductive health显示文摘有缺点的精子功能的主要原因之一是氧化应力,它不仅破坏精子 DNA 的正直而且在精子血浆膜由于蛋白质和类脂化合物的并行的损坏限制这些房间的使肥沃的潜力。如此的氧化压力的起源看起来包含精子线粒体,它有一个趋势作为一篇序言产生 superoxide 阴离子的高水平到进入内在的 apoptotic 串联。不幸地,这些房间有很小的能力因为他们仅仅在基础切除修理(BER ) 拥有第一酶,对如此的攻击作出回应小径, 8-oxoguanine glycosylase 1 (OGG1 ) 。后者成功地创造一个 abasic 地点,而是精子因为他们缺乏下游的蛋白质,不能进一步处理氧化损害(APE1, XRCC1 ) 需要完成修理过程。在第一个有丝分裂的部门的 S 阶段的开始以前继续 BER 小径是卵母细胞的责任。如果一个错误被卵母细胞在开发的这个阶段犯,一个变化将被创造那将在身体在每个房间被代表。如此的机制可以在在作为年龄的后果在他们的细菌线承受了氧化应力的男性的后代观察的童年癌症和另外的疾病解释增加,环境或生活方式因素。在男不孕病人的精子的氧化 DNA 损坏的高流行可以为在 vitro 构思的孩子的健康有含意并且在细菌线为对免费激进的产生的起源的当前的研究担任一位司机。Robert J Aitken Tegan B Smith Matthew S Jobling Mark A Baker Geoffry N De Iuliis 2014Asian Journal of Andrology2014,16,1:48
2全球生态系统服务与自然资本的价值估算显示文摘编者按:地球上的生态系统是一种复杂的生命支持系统,生态系统对人类的贡献,在生态学研究中经常用“社会效益和经济效益”来表述,是可以用经济价值来估算的。然而,由于其复杂性和不确定性,对这两个效益如何进行估价,一直是困扰生态学家和经济学家的重要问题。Cos...Robert Costanza Ralph d'Arge Rudolf de Groot Stephen Farber Monica Grasso Bruce Hannon Karin Limburg Shahid Naeem Robert V.O'neill Jose Paruelo Robert G.Raskin Paul Sutton Marjan van den Belt 陶大立(译) 1999生态学杂志1999,18,2:38
3Generating optical orbital angular momentum at visible wavelengths using a plasmonic metasurface显示文摘Light beams with a helical phase-front possess orbital angular momentum along their direction of propagation in addition to the spin angular momentum that describes their polarisation.Until recently,it was thought that these two‘rotational’motions of light were largely independent and could not be coupled during light–matter interactions.However,it is now known that interactions with carefully designed complex media can result in spin-to-orbit coupling,where a change of the spin angular momentum will modify the orbital angular momentum and vice versa.In this work,we propose and demonstrate that the birefringence of plasmonic nanostructures can be wielded to transform circularly polarised light into light carrying orbital angular momentum.A device operating at visible wavelengths is designed from a space-variant array of subwavelength plasmonic nano-antennas.Experiment confirms that circularly polarised light transmitted through the device is imbued with orbital angular momentum of 62'(with conversion efficiency of at least 1%).This technology paves the way towards ultrathin orbital angular momentum generators that could be integrated into applications for spectroscopy,nanoscale sensing and classical or quantum communications using integrated photonic devices.Ebrahim Karimi Sebastian A Schulz Israel De Leon Hammam Qassim Jeremy Upham Robert W Boyd 2014Light(Science & Applications)2014,3,1:39
4最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL 2014神经病学与神经康复学杂志2014,11,3:31
5FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle.Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes 2020Data Intelligence2020,2,1:26
6Presence of Antibodies to Heat Stress Proteins and its Possible Significance in Workers Exposed to High Temperature and Carbon Monoxide显示文摘Antibodies to the ubiquitous group of stress proteins known as heat shock proteins (Hsps) have been found to be associated with a number of diseases in humans. Hsps are known to be induced by certain xenobiotics, some of which are common in the working environment. The biological significance of the presence of such autoantibodies is presently unclear. In the present study, we used immunoblotting to investigate the presence of antibodies against the different stress proteins, Hsp27, Hsp60, Hsp71, Hse (heat shock cognate ) 73 and Hsp89a and D in groups of workers exposed to high temperature or carbon monoxide. These data were related to a detailed clinical evaluation and to various laboratory measurements including electrocardiogram (ECG), B echogram, white blood cell counts and typing, the activity of alanine aminotransferase (ALT), acid phosphatase (ACP) and alkaline phosphatase (ALP) and lymphocyte DNA damage. Antibodies to Hsp27 and Hsp71 were found more frequently in the high temperature and carbon monoxide-exposed groups than in controls (P (0.05 ). The carbon monoxide-exposed group showed the highest incidence of anti-Hsp antibodies. Anti-Hsp60 antibodies were only detected in workers exposed to high temperature or carbon monoxide. The percentage of workers with abnormal ECG, B echogram changes and displaying hepatitis B antigen (HBsAg ) was higher in the carbon monoxide group than in the control group (P<0.05 ).There was a significant inerease in the activity of ALT in the high temperature and carbon monoxide groups and in the activities of ACP and ALP in the carbon monoxide group (P<0.05 ). The extent of DNA damage measured in lymphoeytes was higher in workers from the high temperature and carbon monoxide-cxposed groups. We suggest that the increased frequeney of antibodies to Hsps is the result of these damages, of the release of denatured Hsps and of a decrease in the phagocytic ability of macrophages in these workers. The data gathered in the present study show a statistical relation between the occurrence of antibodies against Hsps and the frequency of health problems in workers and suggest a potential role for the antibodies as useful biomarkers to assess whether workers are experieneing environmentalWU TANG-CHUN TANGUAY, ROBERT M. WU YANG HE HAN-ZHEN XU DAI-GEN FENG JIA-DE SHI WU-XIANG AND ZHANG GUO-GAO (Institute of Occupational Medicine, Tongji Medical University, Wuhan 430040, China Centre de recherche du CHUL and Lab of Cellular and Develo 1996Biomedical and Environmental Sciences1996,9,4:23
7Agency Problems and Dividend Policies around the World显示文摘RafaelLa Porta FlorencioLopez‐de‐Silanes AndreiShleifer Robert W.Vishny 2007The Journal of Finance2007,,1:12
8Covalently closed-circular hepatitis B virus DNA reduction with entecavir or lamivudine显示文摘AIM: To investigate the reduction in hepatitis B virus(HBV) covalently closed-circular DNA(ccc DNA) with entecavir(ETV) or lamivudine(LAM). METHODS: This analysis included patients who had participated in the randomized Phase Ⅲ study ETV-022 comparing ETV vs LAM in nucleos(t)ide-naive, HBe Agpositive patients. Patients received ETV(0.5 mg daily) or LAM(100 mg daily) for a minimum of 52 wk. Patients were eligible to participate in this sub-study if they had paired biopsies at baseline and week 48 with evaluable measurements for hepatic HBV ccc DNA and total hepatic HBV DNA. The main objective was to compare changes in hepatic HBV ccc DNA and total hepatic HBV DNA at week 48 of ETV or LAM treatment, which was a secondary endpoint of study ETV-022. Additional post hoc analyses included linear regression analyses to assess associations of baseline levels and on-treatment changes of ccc DNA with other baseline factors [sex,age, serum HBV DNA, alanine aminotransferase(ALT), Knodell necroinflammatory score, Ishak fibrosis score, total hepatic HBV DNA, and HBV genotype], or ontreatment factors(changes from baseline at week 48 in serum HBV DNA, ALT, Knodell necroinflammatory score, Ishak fibrosis score, total hepatic HBV DNA, and HBe Ag loss at week 48).RESULTS: Overall, 305 patients(ETV = 159; LAM = 146) of ETV-022 had paired baseline and week 48 liver biopsies with evaluable measurements for hepatic HBV ccc DNA and total hepatic HBV DNA, and were included in this analysis. Baseline demographics and disease characteristics were comparable between the two arms. After 48 wk, ETV resulted in significantly greater reductions in hepatic HBV ccc DNA [-0.9 log10 copies/human genome equivalent(HGEq) vs-0.7 log10 copies/HGEq; P = 0.0033] and total hepatic DNA levels(-2.1 log10 copies/HGEq vs-1.6 log10 copies/HGEq; P < 0.0001) than LAM. Virologic, biochemical, and histologic response rates at week 48 were also greater with ETV than with LAM. Baseline HBV ccc DNA levels were positively associated with baseline levels of serum HBV DNA and total hepatic HBV DNA, and negatively associated with HBV genotype F. On-treatment changes in HBV ccc DNA levels were negatively associated with baseline levels of serum HBV DNA and baseline ALT, and were positively associated with on-treatment changes in the levels of serum HBV DNA, total hepatic HBV DNA levels, and ALT, change in Knodell necroinflammatory score, and HBe Ag loss.CONCLUSION: Forty-eight weeks of ETV resulted in greater reductions in ccc DNA and total hepatic HBV DNA than LAM, but long-term therapy may be needed for ccc DNA elimination.Scott Bowden Stephen Locarnini Ting-Tsung Chang You-Chen Chao Kwang-Hyub Han Robert G Gish Robert A de Man Miao Yu Cyril Llamoso Hong Tang 2015World Journal of Gastroenterology2015,21,15:11
9Surveillance for hepatocellular carcinoma in chronic liver disease:Evidence and controversies显示文摘Primary liver cancer is the sixth most common cancer in the world and the third cause of cancer-related death.Hepatocellular carcinoma(HCC)represents more than90%of primary liver cancers and generally occurs in patients with underlying chronic liver disease such as viral hepatitis,hemochromatosis,primary biliary cirrhosis and non-alcoholic steatohepatitis.Especially cirrhotic patients are at risk of HCC and regular surveillance could enable early detection and therapy,with potentially improved outcome.We here summarize existing evidence for surveillance including ultrasound,other radiological modalities and various serum biomarkers,and current international guideline recommendations for surveillance.Ultrasound andα-fetoprotein(alone or in combination)are most frequently used for surveillance,but their sensitivities and specificities are still far from perfect,and evidence for surveillance remains weak and controversial.Various other potential surveillance tools have been tested,including serum markers as des-carboxyprothrombin,lectin-boundα-fetoprotein,and(most recently)circulating TIE2-expressing monocytes,and radiological investigations such as computed tomographyscan or magnetic resonance imaging-scan.Although early results appear promising,these tools have generally been tested in diagnostic rather than surveillance setting,and in most cases,no detailed information is available on their cost-effectiveness.For the near future,it remains important to define those patients with highest risk of HCC and most benefit from surveillance,and to restrict surveillance to these categories.Suzanne van Meer Robert A de Man Peter D Siersema Karel J van Erpecum 2013World Journal of Gastroenterology2013,19,40:10
10Gastroenteropancreatic neuroendocrine tumours显示文摘Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin 2008Lancet Oncology2008,,1:8
11Measuring Tourist’s Water Footprint in a Mountain Destination of Northwest Yunnan, China显示文摘Monitoring and minimizing tourist’s water consumption is essential for the sustainable development of mountain destinations in the world. However, available data and a generally accepted protocol on such measurement are still limited. This study uses water footprint accounting to quantify tourist’s water demand in the Liming valley, a World Heritage site and a rapidly growing tourism destination in Northwest Yunnan, China. Both the water for direct and indirect use is taken into account based on the consumptive behavior of the tourists in the valley. Data were collected through guesthouse monitoring and a tourist survey in the 2005 tourist season. The results indicate that an average tourist leaves behind a footprint of 5.2 m3 on local water resources per day. Food production and waste dilution are the two most important water consumption factors. The results also show tourists consume more water than the local residents on per capita basis. This suggests more commitment is necessary to cope with this stress by individual tourists. Management implications to make water use more sustainable in mountain destinations are derived from this study.YANG Mingyu Luc HENS Robert DE WULF OU Xiaokun 2011Journal of Mountain Science2011,8,5:7
12眼前节内眼手术应用5%吡咯烷酮碘两种不同用法的前瞻性随机化比较研究显示文摘目的:确定5%吡咯烷酮碘采用两种不同的方法(结膜囊滴两滴和10ml溶液穹窿结膜冲洗)对降低结膜囊菌群的功效。方法:在这项前瞻性对照实验中。将行眼前节手术的200只眼随机分为对照组和研究组。两组病例术前均给予氧氟沙星滴眼液局部点眼和5%吡咯烷酮碘眶周区域皮肤擦洗消毒。术前对照组眼结膜囊内给予2滴5%吡咯烷酮碘溶液,研究组眼用5%吡咯烷酮碘溶液冲洗穹窿结膜。分别于术前和术后4个时间点行结膜细菌培养。结果:研究组78只眼中20只眼(26%)术前结膜细菌培养阳性:对照组94只眼中40只眼(43%)为阳性(P=0.02)。手术结束时。研究组78只眼中14只眼(18%)、对照组94只眼中30只眼(32%)结膜细菌培养阳性(PP=0.05)。结论:手术时应用5%吡咯烷酮碘溶液冲洗穹窿结膜与结膜囊仅点入两滴相比。前者显著降低了结膜细菌培养阳性率。Herminia Mino de Kaspar Robert T. Chang Kuldev Singh Peter R. Egbert Mark S. Blumenkranz Christopher N. Ta 董白霞(译) 马景学(校) 2005美国医学会眼科杂志(中文版)2005,17,3:6
13Cholesterol confusion and statin controversy显示文摘The role of blood cholesterol levels in coronary heart disease(CHD) and the true effect of cholesterollowering statin drugs are debatable. In particular,whether statins actually decrease cardiac mortality and increase life expectancy is controversial. Concurrently,the Mediterranean diet model has been shown to prolong life and reduce the risk of diabetes,cancer,and CHD. We herein review current data related to both statins and the Mediterranean diet. We conclude that the expectation that CHD could be prevented or eliminated by simply reducing cholesterol appears unfounded. On the contrary,we should acknowledge the inconsistencies of the cholesterol theory and recognize the proven benefits of a healthy lifestyle incorporating a Mediterranean diet to prevent CHD.Robert DuBroff Michel de Lorgeril 2015World Journal of Cardiology2015,7,7:6
14Navigated liver surgery:State of the art and future perspectives显示文摘Background:In recent years,the development of digital imaging technology has had a significant influence in liver surgery.The ability to obtain a 3-dimensional(3D)visualization of the liver anatomy has provided surgery with virtual reality of simulation 3D computer models,3D printing models and more recently holograms and augmented reality(when virtual reality knowledge is superimposed onto reality).In addition,the utilization of real-time fluorescent imaging techniques based on indocyanine green(ICG)uptake allows clinicians to precisely delineate the liver anatomy and/or tumors within the parenchyma,applying the knowledge obtained preoperatively through digital imaging.The combination of both has transformed the abstract thinking until now based on 2D imaging into a 3D preoperative conception(virtual reality),enhanced with real-time visualization of the fluorescent liver structures,effectively facilitating intraoperative navigated liver surgery(augmented reality).Data sources:A literature search was performed from inception until January 2021 in MEDLINE(Pub Med),Embase,Cochrane library and database for systematic reviews(CDSR),Google Scholar,and National Institute for Health and Clinical Excellence(NICE)databases.Results:Fifty-one pertinent articles were retrieved and included.The different types of digital imaging technologies and the real-time navigated liver surgery were estimated and compared.Conclusions:ICG fluorescent imaging techniques can contribute essentially to the real-time definition of liver segments;as a result,precise hepatic resection can be guided by the presence of fluorescence.Furthermore,3D models can help essentially to further advancing of precision in hepatic surgery by permitting estimation of liver volume and functional liver remnant,delineation of resection lines along the liver segments and evaluation of tumor margins.In liver transplantation and especially in living donor liver transplantation(LDLT),3D printed models of the donor’s liver and models of the recipient’s hilar anatomy can contribute further to improving the results.In particular,pediatric LDLT abdominal cavity models can help to manage the largest challenge of this procedure,namely large-for-size syndrome.Paschalis Gavriilidis Bjørn Edwin Egidijus Pelanis Ernest Hidalgo Nicola de’Angelis Riccardo Memeo Luca Aldrighetti Robert P Sutcliffe 2022Hepatobiliary & Pancreatic Diseases International2022,21,3:6
15Management and outcome of hepatocellular adenoma with massive bleeding at presentation显示文摘AIM To evaluate outcome of acute management and risk of rebleeding in patients with massive hemorrhage due to hepatocellular adenoma(HCA). METHODS This retrospective cohort study included all consecutive patients who presented to our hospital with massive hemorrhage(grade Ⅱ or Ⅲ) due to ruptured HCA and were admitted for observation and/or intervention between 1999-2016. The diagnosis of HCA was based on radiological findings from contrastenhanced magnetic resonance imaging(MRI) or pathological findings from biopsy or resection of the HCA. Hemorrhage was diagnosed based on findings from computed tomography or MRI. Medical records were reviewed for demographic features, clinical presentation, tumor features, initial and subsequent management, short-and long-term complications and patient and lesion follow-up. RESULTS All patients were female(n = 23). Treatment in the acute phase consisted of embolization(n = 9, 39.1%), conservative therapy(n = 13, 56.5%), andother intervention(n = 1, 4.3%). Median hemoglobin level decreased significantly more on days 0-3 in the intervention group than in the patients initially treated conservatively(0.9 mmol/L vs 2.4 mmol/L respectively, P = 0.006). In total, 4 patients suffered severe shortterm complications, which included hypovolemic shock, acute liver failure and abscess formation. After a median follow-up of 36 mo, tumor regression in nonsurgically treated patients occurred with a median reduction of 76 mm down to 25 mm. Four patients underwent secondary(elective) treatment(i.e., tumor resection) to address HCA size of > 5 cm and/or desire for future pregnancy. One case of rebleeding was documented(4.3%). None of the patients experienced long-term complication(mean follow-up time: 36 mo). CONCLUSION With a 4.3% risk of rebleeding, secondary(elective) treatment of HCA after massive hemorrhage may only be considered in patients with persistent HCA > 5 cm.Anne J Klompenhouwer Robert A de Man Maarten GJ Thomeer Jan NM Ijzermans 2017World Journal of Gastroenterology2017,23,25:5
16NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer显示文摘Couturier-Maillard Aurélie Secher Thomas Rehman Ateequr Normand Sylvain De Arcangelis Adéle Haesler Robert Huot Ludovic Grandjean Teddy Bressenot Aude Delanoye-Crespin Anne Gaillot Olivier Schreiber Stefan Lemoine Yves Ryffel Bernhard Hot D 2013Journal of Clinical Investigation2013,,2:5
17Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B显示文摘E. Jenny Heathcote Patrick Marcellin Maria Buti Edward Gane Robert A. De Man Zahary Krastev George Germanidis Samuel S. Lee Robert Flisiak Kelly Kaita Michael Manns Iskren Kotzev Konstantin Tchernev Peter Buggisch Frank Weilert Oya Ovunc Kurdas Mitchell L 2011Gastroenterology2011,,1:5
18Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar 2009The Lancet2009,,9666:5
19Executive Summary: Heart Disease and Stroke Statistics— 2010 Update: A Report From the American Heart Association显示文摘Donald Lloyd-Jones Robert J. Adams Todd M. Brown Mercedes Carnethon Shifan Dai Giovanni De Simone T. Bruce Ferguson Earl Ford Karen Furie Cathleen Gillespie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern P. Michael Ho Virginia Howard Brett Kissela Stev 2010Circulation2010,,7:5
202013 ESH/ESC Guidelines for the management of arterial hypertension显示文摘Giuseppe Mancia Robert Fagard Krzysztof Narkiewicz Josep Redon Alberto Zanchetti Michael B?hm Thierry Christiaens Renata Cifkova Guy De Backer Anna Dominiczak Maurizio Galderisi Diederick E. Grobbee Tiny Jaarsma Paulus Kirchhof Sverre E. Kjeldsen Stéphane 2013European Heart Journal2013,,28:5
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