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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 3 | Low-dose thoracoab- dominal irradiation for the treatment of refractory chronic graft- versus-host disease显示文摘 | Robin M Guardiola P Girinsky T | 2005 | Transplantation2005，80，5： | 1 |
| 4 | Molecularpaleohydrology: Interpreting the hydrogen isotopiccomposition of lipid biomarkers from photosynthesizing organisms 显示文摘 | Sachse D Billault I Bowen G Y Chikaraishi Y Dawson T E Feakins S J Freeman K H Magill C R McInerney F A vander Meer M T J Polissar P Robins R J Sachs J P Schmidt HL Sessions A L White J W C West J B Kahmen A | 2012 | Ann Rev Earth Planet Sci2012，40，： | 1 |
| 5 | New specifications for exponential random graph models 显示文摘 | Snijders T A Pattison P E Robins G L | 2006 | Sociological Methodology: (S1467-9531)2006，36，1： | 1 |
| 6 | Bak core and latch domains separate during activation,and freed core domains form symmetric homodimers显示文摘 | Brouwer J M Westphal D Dewson G Robin A Y Uren R T Bartolo R Thompson G V Colman P M Kluck R M Czabotar P E | 2014 | Mol Cell2014，55，6： | 1 |
| 7 | The 'Little Five' :exploring the nomological network of the Five Factor Model of personality in adolescent boys显示文摘 | John O P Caspi A Robins R W Moffitt T E Stouthamer- Loeber M | 1994 | Child Development1994，65，： | 1 |
| 8 | Evaluation of bone turnover in type Ⅰ osteoporosis using biochemical markers specific for both bone formation and bone resorption显示文摘 | EASTELL R ROBINS S P COLWELL T | 1993 | Osteoporos Int1993，3，： | 1 |
| 9 | The'Little Five': Exploring the Nomological Network of The Five Factor Mode of Personality in Adolescent Boys显示文摘 | JOHN O P CASPI A ROBINS T E | 1994 | Child Development1994，，： | 1 |
| 10 | Nutrient and microbial dynamics in high-intensity,zero-exchange shrimp ponds in Belize显示文摘 | Michele A B Peter J T Robins P M | 2003 | Aquaculture2003，219，： | 1 |
| 11 | New specifications for exponential random graph models显示文摘 | Snijders T A B Pattison P E Robins G L | 2006 | Sociological Methodology2006，36，1： | 1 |
| 12 | Recent developments in exponential random graph(p*) models for social networks显示文摘 | Robins G L Snijders T A B Wang P | 2007 | Social Networks2007，29，2： | 1 |
| 13 | Comment on 'Use of deterministic modelsin sports and exercise biomechanics research' by Chow and Knudson:2011显示文摘 | GLAZIER P S ROBINS M T | 2012 | Sports Biomechanics2012，11，1： | 1 |
| 14 | New Specifications for Exponential Random Graph Models 显示文摘 | Snijders T A B Pattison P E Robins G L | 2006 | Sociological Methodology2006，36，1： | 1 |
| 15 | Recent Developments in Exponential Random Graph (p*) Models for Social Networks 显示文摘 | Robins G Snijders T Wang P | 2007 | Social Networks2007，29，2： | 1 |
| 16 | Recent Developments in Exponential Random Graph (p*) Models for Social Networks 显示文摘 | ROBINS G L SNIJDERS T WANG P | 2007 | Social Networks2007，29，2： | 1 |
| 17 | New Specifications for Exponential Random Graph Models 显示文摘 | SNIJDERS T PATHSON P ROBINS G L | 2006 | Sociological Methodology2006，36，1： | 1 |
| 18 | New specifications for exponential random graph models 显示文摘 | Snijders T A B Pattison P Robins G L Handcock M | 2006 | Sociological Methodology2006，36，： | 1 |
| 19 | New specifications for exponential random graph models 显示文摘 | Snijders T A B Pattison P Robins G L | 2006 | Sociological Methodology2006，34，： | 1 |
| 20 | Recent developments in exponential random graph (p * ) models for social networks 显示文摘 | Robins G Snijders T Wang P Handcock M Pattison P | 2007 | Social Networks2007，29，： | 1 |
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