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| 1 | Management of recurrent rectal cancer:A population based study in greater Amsterdam显示文摘AIM: To analyze,retrospectively in a population-based study,the management and survival of patients with recurrent rectal cancer initially treated with a macroscopically radical resection obtained with total mesorectal excision (TME). METHODS: All rectal carcinomas diagnosed during 1998 to 2000 and initially treated with a macroscopically radical resection (632 patients) were selected from the Amsterdam Cancer Registry. For patients with recurrent disease,information on treatment of the recurrence was collected from the medical records. RESULTS: Local recurrence with or without clinically apparent distant dissemination occurred in 62 patients (10%). Thirty-two patients had an isolated local recurrence. Ten of these 32 patients (31%) underwent radical re-resection and experienced the highest survival (three quarters survived for at least 3 years). Eight patients (25%) underwent non-radical surgery (median survival 24 mo),seven patients (22%) were treated with radio-and/or chemotherapy without surgery (median survival 15 mo) and seven patients (22%) only received best supportive care (median survival 5 mo). Distant dissemination occurred in 124 patients (20%) of whom 30 patients also had a local recurrence. The majority (54%) of these patients were treated with radio-and/or chemotherapy without surgery (median survival 15 mo). Twenty-seven percent of these patients only received best supportive care (median survival 6 mo),while 16% underwent surgery for their recurrence. Survival was best in the latter group (median survival 32 mo). CONCLUSION: Although treatment options and survival are limited in case of recurrent rectal cancer after radical local resection obtained with TME,patients can benefit from additional treatment,especially if a radical resection is feasible. | Roel Bakx Otto Visser Judith Josso Sybren Meijer J Frederik M Slors J Jan B van Lanschot | 2008 | World Journal of Gastroenterology2008，14，39： | 17 |
| 2 | Percutaneous closure of secundum type atrial septal defects:More than 5-year follow-up显示文摘AIM: To investigate long-term efficacy of two different devices more than five years after percutaneous atrial septal defect(ASD) closure in adults.METHODS: All patients who underwent percutaneous closure of an ASD in the St. Antonius Hospital, Nieuwegein, The Netherlands, between February 1998 and December 2006 were included. Percutaneous closure took place under general anaesthesia and transesophageal echocardiographic moni toring. Transthoracic echocardiography(TTE) was performed 24 h post-procedure to visualize the device position and to look for residual shunting using color Doppler. All complications were registered. All patients were invited for an outpatient visit and contrast TTE more than 5-years after closure. Efficacy was based on the presence of a residual right-to-left shunt(RLS), graded as minimal, moderate or severe. The presence of a residual left-to-right shunt(LRS) was diagnosed using color Doppler, and was not graded. Descriptive statistics were used for patients' characteristics. Univariate analysis was used to identify predictors for residual shunting.RESULTS: In total, 104 patients(mean age 45.5 ± 17.1 years) underwent percutaneous ASD closure using an Amplatzer device(ASO) in 76 patients and a Cardioseal/Starflex device(CS/SF) in 28 patients. The mean follow-up was 6.4 ± 3.4 years. Device migration occurred in 4 patients of whom two cases occurred during the index hospitalization(1 ASO, 1 CS/SF). The other 2 cases of device migration occurred during the first 6 mo of follow-up(2 CS/SF). The recurrent thrombo-embolic event rate was similar in both groups: 0.4% per follow-up year. More than 12 mo post-ASD closure and latest follow-up, new-onset supraventricular tachyarrhythmia's occurred in 3.9% and 0% for the ASO and CS/SF group, respectively. The RLS rate at latest follow-up was 17.4%(minimal 10.9%, moderate 2.2%, severe 4.3%) and 45.5%(minimal 27.3%, moderate 18.2%, severe 0%) for the ASO- and CS/SF groups, respectively. There was no residual LRS in both groups.CONCLUSION: Percutaneous ASD closure has good long-term safety and efficacy profiles. The residual RLS rate seems to be high more than 5 years after closure, especially in the CS/SF. Residual LRS was not observed. | Roel JR Snijder Maarten J Suttorp Jurrien M Ten Berg Martijn C Post | 2015 | World Journal of Cardiology2015，7，3： | 6 |
| 3 | Transanal total mesorectal excision:a valid option for rectal cancer?显示文摘Low anterior resection can be a challenging operation, especially in obese male patients and in particular after radiotherapy. Transanal total mesorectal excision(Ta TME) might offer technical advantages over laparoscopic or open approaches particularly for tumors in the distal third of the rectum. The aim of this article is to review the current experience with Ta TME. The limits and future developments are also explored. Although the experience with Ta TME is still limited, it might be a promising alternative to laparoscopic TME, especially for difficult cases where laparoscopy is too demanding. The preliminary data on complications and short-term oncological outcomes are good, but also emphasize the importance of careful patient selection. Finally, there is a need for large-scale trials focusing on long-term outcomes and oncological safety before widespread adoption can be recommended. | Nicolas C Buchs Gary A Nicholson Frederic Ris Neil J Mortensen Roel Hompes | 2015 | World Journal of Gastroenterology2015，21，41： | 3 |
| 4 | Prognostically relevant gene signatures of high-grade serous ovarian carcinoma显示文摘 | Verhaak Roel G W Tamayo Pablo Yang Ji-Yeon Hubbard Diana Zhang Hailei Creighton Chad J Fereday Sian Lawrence Michael Carter Scott L Mermel Craig H Kostic Aleksandar D Etemadmoghadam Dariush Saksena Gordon Cibulskis Kristian Duraisamy Sekhar | 2013 | Journal of Clinical Investigation2013，，1： | 2 |
| 5 | Low level lead exposure and blood pressure显示文摘 | Roels H Lauwerys RR | 1995 | J Hum Hypertens1995，5，： | 1 |
| 6 | Interlabo- properties of porous build- ing materials 显示文摘 | ROELS S CARMELIET J ratory comparison of hygric HENS H | 2004 | Journal of Thermal Envelope and Building Science2004，27，4： | 1 |
| 7 | Urinary neutral endopeptidase inworkers exposed to cadmium: interaction With Cigarette smoking 显示文摘 | Nortier J Bernard A RoelS H | 1997 | Occup Environ MED1997，54，： | 1 |
| 8 | Urinary neutral endopeptidase in workers exposed to cadmium:interaction with cigarette smoking显示文摘 | Nortier J Bernard A Roels H | 1997 | Occup Environ Med1997，54，6： | 1 |
| 9 | Incomplete sanitation of a meat grinder and ingestion of raw ground beef: contributing factors to a large outbreak of Salmonella typhimurium infection显示文摘 | ROELS T H FRAZAK P A KAZMIERCZAK J J | 1997 | Epidemiol Infect1997，119，2： | 1 |
| 10 | Salt induces vascular AT1 receptor overexpression in vitro and in vivo显示文摘 | Nickenig G Strehlow K Roeling J | 1998 | Hypertension1998，31，6： | 1 |
| 11 | The relationship between cadmium exposure or body burden and the concentration of cadmium in blood and urine in man显示文摘 | LAUWERYS R R BUCHET J P ROELS H | 1976 | International archives of occupational and environmental health1976，36，4： | 1 |
| 12 | Environmen- tal exposure to cadmium, forearm bone density, and risk of fractures: Prospective population study显示文摘 | Staessen J A Roels H A Emelianov D | 1999 | Lancet1999，353，9159： | 1 |
| 13 | Oxidation of et ,ω-diols using the Dess-Martin periodinane 显示文摘 | Roels J Metz P | 2001 | Synlett2001，，6： | 1 |
| 14 | Biological monitoring of occupational exposure to n-hexane by measurement of urinary 2,5-hexanedione显示文摘 | Cardona A Marhuenda D Roel J | | 0，，： | 1 |
| 15 | Effects of intermittent hypoxic training on amino and fatty acid oxidative combustion in human permeabilized muscle fibers显示文摘 | ROELS B THOMAS C BENTLEY D J | 2007 | J Appl Physiol2007，102，1： | 1 |
| 16 | Biological formation of volatile phosphorus compounds显示文摘 | Roels J Verstraete W | 2001 | Bioresource Technology2001，79，3： | 1 |
| 17 | A requirement engineering framework for cross-organizational ERP systems 显示文摘 | Maya D Roel J Wieringa | 2006 | Re- quirements Engineering2006，11，3： | 1 |
| 18 | Renal function and hyperfiltration capacity in smelter workers with high bone lead 显示文摘 | Roels H Lauwerys R Konings J | 1994 | Occup Environ Med1994，51，： | 1 |
| 19 | Reduction of observer variation using matched CT - PET for lung cancer delineation : A three - dimensional analysis 显示文摘 | Roel JH Sreenbakkers R J Duppen JC | 2006 | Int J Radiat Oncol Biol Phys2006，64，2： | 1 |
| 20 | Cadmium a possible etio- logical factor in peripheral polyneuropathy 显示文摘 | Viaene M K Roels H A Leendcrs J | 1999 | Neurotoxicology1999，20，1： | 1 |
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