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	题名	作者	年代	出处	被引量
1	Comparison of the chloride channel activator lubiprostone and the oral laxative Polyethylene Glycol 3350 on mucosal barrier repair in ischemic-injured porcine intestine显示文摘AIM: To investigate the effects of lubiprostone and Polyethylene Glycol 3350 (PEG) on mucosal barrier repair in ischemic-injured porcine intestine. METHODS: Ileum from 6 piglets (approximately 15 kg body weight) was subjected to ischemic conditions by occluding the local mesenteric circulation for 45 min in vivo. Ileal tissues from each pig were then harvested and mounted in Ussing chambers and bathed in oxygenated Ringer's solution in vitro. Intestinal barrier function was assessed by measuring transepithelial electrical resistance (TER) and mucosal-to-serosal fluxes of 3H-mannitol and 14C-inulin. Statistical analyses of data collected over a 120-min time course included 2-way ANOVA for the effects of time and treatment on indices of barrier function. RESULTS: Application of 1 μmol/L lubiprostone to the mucosal surface of ischemic-injured ileum in vitro induced significant elevations in TER compared to non-treated tissue. Lubiprostone also reduced mucosal-to-serosal fluxes of 3H-mannitol and 14C-inulin. Alternatively,application of a polyethylene laxative (PEG,20 mmol/L) to the mucosal surface of ischemic tissues significantly increased flux of 3H-mannitol and 14C-inulin. CONCLUSION: This experiment demonstrates that lubiprostone stimulates recovery of barrier function in ischemic intestinal tissues whereas the PEG laxative had deleterious effects on mucosal repair. These results suggest that,unlike osmotic laxatives,lubiprostone stimulates repair of the injured intestinal barrier.	Adam J Moeser Prashant K Nighot Birgit Roerig Ryuji Ueno Anthony T Blikslager	2008	World Journal of Gastroenterology2008，14，39：	2
2	Characterization and functional analysis of the nucleotide binding fold in human peroxisomal ATP binding cassette transporters显示文摘	Roerig P Mayerhofer P Holzinger A	2001	FEBS Lett2001，492，12：	1
3	Atypical antipsychotic- induced weight gain: insights into mechanisms of action 显示文摘	Roerig JL Steffen K J Mitchell JE	2011	CNSDrugs2011，25，12：	1
4	Diagnosis and management of generalized anxiety disorder显示文摘		1999	39(6):811~8211999，39，6：	1
5	Role of 5 hydroxytryptamine3 antagonists in the prevention o{ emesis caused by anticancer thera- py 显示文摘	Karim F Roerig S C Saphier D	1996	Biochem Pharmacol1996，52，：	1
6	Role of 5-hydrox- ytrptamine(5-HT3) antagonists in the prevention of emeisi caused by anticancer therapy显示文摘	Karim F Roerig SC Saphier D	1996	Biochem Pharmacol1996，52，5：	1
7	Differential effects of antisense oligodeoxynucleotides directed against g(zalpha) and g(oalpha) on antinociception produced by spinal opioid and alpha(2) adrenergic receptor agonists显示文摘	Roerig SC	2000	Pain2000，87，2：	1
8	Emerging drugs for eating disorder treatment显示文摘	Steffen KJ James L Roerig James E Mitchell	2006	Expert Opin Emerg Drugs2006，11，2：	1
9	Microarray-based gene expression profiling of benign,atypical and anaplastic meningiomas identifies novel genes associated with meningioma progression显示文摘	Wrobel G Roerig P Kokocinski F	2005	Int J Cancer2005，114，2：	1
10	The eating disorders medicine cabinet revisited : a clinician' s guide to appetite suppressants and diuretics显示文摘	James L Roerig James E	2003	Int J Eat Disord2003，33，4：	1
11	Neurotransmitters and gap junctions in developing neural circuits显示文摘	Roerig B Feller M B	2000	Brain Research Review2000，32，：	1
12	Neurotransmitters and gap junctions in developing neural circuits显示文摘	Roerig B Feller MB		0，，01：	1
13	Dye-coupling between pyramidal neurons in developing rat prefrontal and frontal cortex is reduced by protein kinase a activation and dopamine显示文摘	Roerig B Klausa G Sutor B	1995	J Neuroscience1995，15，：	1
14	Characterization and functional analysis of the nucleotide binding fold in human peroxisomal ATP binding cassette transporters显示文摘	Roerig P Mayerhofer P Holzinger A	2001	FEBS Lett2001，492，12：	1
15	Beta-adrenoreceptor acrivation reduces dye coupling between immature rat neocortical neurons显示文摘	Roerig B Klausa G Sutor B	1995	Neuro Report1995，6，18：	1
16	The effects of morphine on sympathetic transmission in the stellate ganglion of the cat显示文摘	Bosnjak Z J Seagard J L Roerig D L	1986	Can J Physiol Pharmacol1986，64，7：	1
17	The effects of stereoisomers of the alpha2-adrenergic agonist medetomidine on systemic and coronary hemodynamics in conscious dogs显示文摘	Sehmeling WT Kampine JP Roerig DL	1991	ANESTHESIOLOGY1991，75，24：	1
18	Canine cardiac muscarinic receptors,G- prote ins, and adenylate cyclase after long-term morphine显示文摘	Roerig SC	1999	J Pharmacol Exp Ther1999，291，2：	1
19	Influence of gravity on radiographic contrast material-based measurements of regional blood flow distribution显示文摘	Clough AV Haworth ST Roerig DL	2003	Acad Radiol2003，10，2：	1
20	Diagnosis and management of generalized anxiety disorder 显示文摘	ROERIG JL	1999	J Am Pharm Assoc1999，39，6：	1

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