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| 1 | Efficacy of Lycium barbarum polysaccharide in adolescents with subthreshold depression: interim analysis of a randomized controlled study显示文摘Subthreshold depression is a highly prevalent condition in adolescents who are at high risk for developing major depressive disorder.In preclinical models of neurological and psychiatric diseases,Lycium barbarum polysaccharide(LBP)extracted from Goji berries had antidepressant effects including but not limited to anti-oxidative and anti-inflammatory properties.However,the effect of LBP on subthreshold depression is unclear.To investigate the clinical efficacy and safety of LBP for treating subthreshold depression in adolescents,we conducted a randomized,double-blind,placebo-controlled trial(RCT)with 29 adolescents with subthreshold depression recruited at The Fifth Affiliated Hospital of Guangzhou Medical University.The participants were randomly assigned to groups where they received either 300 mg LBP(LBP group,n=15,3 boys and 12 girls aged 15.13±2.17 years)or a placebo(placebo group,n=14,2 boys and 12 girls aged 15±1.71 years)for 6 successive weeks.Interim analyses revealed that the LBP group exhibited a greater change in Hamilton Depression Scale(HAMD-24)scores relative to the baseline and a higher remission rate(HAMD-24 total score≤7)at 6 weeks compared with the placebo group.Scores on the Beck Depression Inventory-II(BDI-II),Pittsburgh Sleep Quality Index(PSQI),Kessler Psychological Distress Scale(Kessler),and Screen for Child Anxiety-Related Emotional Disorders(SCARED)were similar between the LBP and placebo groups.No side effects related to the intervention were reported in either group.These results indicate that LBP administration reduced depressive symptoms in adolescents with subthreshold depression.Furthermore,LBP was well tolerated with no treatment-limiting adverse events.Clinical trials involving a larger sample size are needed to further confirm the anti-depressive effects of LBP in adolescents with subthreshold depression.This study was approved by the Medical Ethics Committee of the Fifth Affiliated Hospital of Guangzhou Medical University(Guangzhou,China;approval No.L2019-08)on April 4,2019 and was registered on ClinicalTrials.gov(identifier:NCT04032795)on July 25,2019. | Xiaoyue Li Xuan Mo Tao Liu Robin Shao Kayla Teopiz Roger S.McIntyre Kwok-Fai So Kangguang Lin | 2022 | Neural Regeneration Research2022，17，7： | 6 |
| 2 | Extraction of DNA from milligram amounts of fresh,diversity,berbarium and mummified plant tissues显示文摘 | Rogers SO Bendich AJ 1985 | 1985 | Plant Mol Biol1985，5，： | 1 |
| 3 | Extraction of DNA from milligram amounts of fresh,herbarium and mummified plant tissues显示文摘 | Rogers SO Bendich AJ | 1985 | Plant Mol Biol1985，5，2： | 1 |
| 4 | Extraction of DNA from milligram amounts of fresh, herbarium and mummified plant tissues 显示文摘 | Rogers SO Bendich AJ | 1985 | Plant Molecular Biology1985，5，2： | 1 |
| 5 | Extraction of DNA from milligram amounts of fresh, herbarium and nmmmified plant tissues 显示文摘 | Rogers SO Bendich AJ | 1985 | Plant Molecular Biology1985，5，2： | 1 |
| 6 | Crystal structure of theMycobacterium tuberculosis dUTPase: insights into the catalytic mechanism 显示文摘 | Chan S Segelke B Lekin T Krupka H Cho US Kim MY So M Naranjo CM Rogers YC Park MS Waldo GS Pashkov I Cascio D Perry JL Sawaya MR | 2004 | J Mol Biol2004，341，2： | 1 |
| 7 | Extraction of DNA from plant tissues显示文摘 | Rogers SO Bendieh AJ 1988 | 1988 | Plant Mol Biol Manual1988，6，： | 1 |
| 8 | Disparity in outcomes of surgical revascularization for limb salvage race and gender are synergistic determinants of vein graft failure and limb loss显示文摘 | Nguyen LL Hevelone N Rogers SO | | Circulation0，，： | 1 |
| 9 | DNA damage cansed by common cytological fixativest显示文摘 | Douglas MP Rogers SO | 1998 | Mutat Res1998，401，12： | 1 |
| 10 | Extraction of DNA from milligram amounts of fresh,herbarium and mummified plant tissues显示文摘 | Rogers SO Bendich AJ | 1985 | Plant Mol Biol1985，5，： | 1 |
| 11 | The question of quality显示文摘 | Zinner MJ Rogers SO Jr | 2005 | World J Surg2005，29，10： | 1 |
| 12 | Multivariable predictors of postoperative venous thromboembolic events after general and vascular surgery: results from the patient safety in surgery study显示文摘 | Rogers SO Jr Kilaru RK Hosokawa P | 2007 | J Am Coll Surg2007，204，6： | 1 |
| 13 | Extraction of DNA from milligram amounts of fresh,herbarium and mummified plant tissues显示文摘 | Rogers SO Bendich AJ | 1985 | Plant Mol Biol1985，5，： | 1 |
| 14 | Extraction of DNA from milligram amounts of fresh, herbarium and mummified plant tissues 显示文摘 | Rogers SO Bendich AJ | 1985 | Plant Molecular Biology1985，5，2： | 1 |
| 15 | Relation of sur?geon and hospital volume to processes and outcomes of colorec?tal cancer surgery显示文摘 | Rogers SO Jr Wolf RE Zaslavsky AM | 2006 | Ann Surg2006，244，6： | 1 |
| 16 | Giant colonic lipoma as lead point for intermittent colo-colonic intussusception显示文摘 | Rogers SO JR Lee MC Ashley SW | | 0，，06： | 1 |
| 17 | The role of perioperative hyperglycemia in postoperative infections显示文摘 | Rogers SO Jr Zinner MJ | 2009 | Adv Surg2009，43，： | 1 |
| 18 | DNA damage caused by common cytological fixatives显示文摘 | Rogers SO | 1998 | Mut Res1998，401，： | 1 |
| 19 | Analysis of surgical errors in closed malpractice claims at 4 liability insurers显示文摘 | Rogers SO Jr Gawande AA Kwaan M | 2006 | Surgery2006，140，1： | 1 |
| 20 | Urinary tract infection in sur- gical patients 显示文摘 | Hashmi S Kelly E Rogers SO | 2003 | Am J Surg2003，186，1： | 1 |
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