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| 1 | Combination immunotherapy with Survivin and luteinizing hormone-releasing hormone fusion protein in murine breast cancer model显示文摘AIM To investigate the therapeutic potential of two recombinant proteins, Survivin and luteinizing hormone-releasing hormone (LHRH) fusion protein [LHRH(6 leu)-LTB] for immunotherapy of breast cancer.METHODS Murine 4 T-1 breast cancer model was used to evaluate the efficacy of recombinant proteins in vivo. Twenty four Balb/c mice were divided into 4 groups of 6 mice each. Recombinant Survivin and LHRH fusion protein, alone or in combination, were administered along with immunomodulator Mycobacterium indicus pranii (MIP) in Balb/c mice. Unimmunized or control group mice were administered with phosphate buffer saline. Each group was then challenged with syngeneic 4 T-1 cells to induce the growth of breast tumor. Tumor growth was monitored to evaluate the efficacy of immune-response in preventing the growth of cancer cells.RESULTS Preventive immunization with 20 μg recombinant Survivin and MIP was effective in suppressing growth of 4 T-1 mouse model of breast cancer (P = 0.04) but 50 μg dose was ineffective in suppressing tumor growth. However, combination of Survivin and LHRH fusion protein was more effective in suppressing tumor growth (P = 0.02) as well as metastasis in vivo in comparison to LHRH fusion protein as vaccine antigen alone.CONCLUSION Recombinant Survivin and MIP suppress tumor growth significantly. Combining LHRH fusion protein with Survivin and MIP enhances tumor suppressive effects marginally which provides evidence for recombinant Survivin and LHRH fusion protein as candidates for translating the combination cancer immunotherapy approaches. | Himani Garg Rohit Singh Hada Jagdish C Gupta G P Talwar Shweta Dubey | 2018 | World Journal of Clinical Oncology2018，9，8： | 2 |
| 2 | Risk factors for endophthalmitis following cataract surgery-our experience at a tertiary eye care centre in India显示文摘AIM: To determine the risk factors for acute endophthalmitis after cataract extraction in a tertiary care centre in India.·METHODS: We performed a nested case control study within a retrospective cohort. The surgical records of all patients with clinically diagnosed endophthalmitis within one month after cataract surgery, performed between January 2006 and December 2009, were reviewed. These were compared with randomly selected age and gender-matched controls, from patients having routine cataract surgery within ±1wk of the endophthalmitis case.Univariable and multivariable analysis were performed to identify risk factors for endophthalmitis.· RESULTS: Of the total 33 856 cataract surgeries performed during this period, there were 57 cases of postoperative acute endophthalmitis that met our study criteria. Thus, the overall incidence of endophthalmitis in our cohort was 1.6 per 1000 cataract extractions performed. Mean age of cases was 55.9y(SD: 10.9y) and for controls was 55.6y(SD: 9.8y). Thirty-five cases(61.4%)and 133 controls(59.6%) were males. Median time of onset of endophthalmitis was 4d(IQR 2-9d; range: 1-30d).Thirty-nine cases(68.4%) presented within 7d and 27 cases(47.4%) were culture positive. Two hundred and twenty-three age and gender matched controls were selected. In multivariate analysis, endophthalmitis was associated with posterior capsular rupture(PCR) during surgery(OR 6.98, 95%CI: 2.22-21.98), phacoemulsification via scleral incision with a foldable intraocular lens(IOL)implantation(OR 3.02, 95%CI: 1.13-8.04) and ocular comorbidity(OR 2.32, 95%CI: 1.11-4.87).·CONCLUSION: PCR, presence of ocular co-morbidity,and phacoemulsification via scleral incision with foldable-IOL were found to be independent risk factors for acute endophthalmitis. | Rohit C.Khanna Vanita Pathak Ray Madhavi Latha Sandra D Cassard Annie Mathai Garudadri C Sekhar | 2015 | International Journal of Ophthalmology(English edition)2015，8，6： | 2 |
| 3 | Production, purification, characterization, and application of lipases显示文摘 | Rohit S Yusuf C Uttam C B | 2001 | Biotechnology Advances2001，19，8： | 1 |
| 4 | Pilot tone selection for channel estimation in a mobile OFDM system显示文摘 | Rohit N John C | 1998 | IEEE Transactions on Consumer Electronics1998，44，3： | 1 |
| 5 | A comparative study of the gyrus plasmakinetic electrosurgical system versus conventional loop electroresection (TURP) for the treatment of bladder outflow obstruction-six month data显示文摘 | Stephanie S Anthony B Rohit C | 2002 | Eur Urol Suppl2002，1，1： | 1 |
| 6 | Production, purification, character- ization, and applications of lipases 显示文摘 | Rohit S Uttam C B | 2001 | Biotechnology Ad- vances2001，19，： | 1 |
| 7 | Relationships between providers and users of marketing research: the dynamics of trust within and between organizations 显示文摘 | GERALD Z ROHIT D | 1992 | Journal of Marketing Research1992，29，： | 1 |
| 8 | Unilateral visual impairment in rural south India-Andhra Pradesh Eye Disease Study(APEDS)显示文摘AIM: To report the prevalence and causes of unilateral visual impairment(UVI) in rural population of all ages in rural Andhra Pradesh, India.·METHODS: A population-based cross sectional study using a multi-stage cluster sampling methodology was carried out in West Godavari, Adilabad and Mahbubnagar districts in south India. A comprehensive eye examination that included presenting and best corrected visual acuity and dilated fundus examination was conducted by trained professionals. UVI is defined as presenting visual acuity <6/18 in one eye but ≥6/18 in other eye. Multiple logistic regression analysis was used to test association of UVI with socio-demographic risk factors.· RESULTS: Data were analyzed for 6634/7771 participants after excluding those with bilateral visual impairment. The mean age of the participants was 27.4y(Standard deviation: 17.9y), 51.9% were women and49.1% were educated. The prevalence of UVI was 7.8%(95% CI: 7.2%- 8.5%). Uncorrected refractive error(60.8%), cataract(17.4%) and retinal causes(6.6%) were the leading causes of UVI. On multiple logistic regression analyses, older age, not having education, living in welloff district had significantly higher odds of being associated with UVI. UVI was not associated with gender.·CONCLUSION: UVI is common in rural south India.Most of it is due to cataract and refractive errors, both of which can be addressed at primary and secondary levelsof eye care. Burden of UVI should also be considered in planning eye care services. | Srinivas Marmamula Rohit C Khanna Gullapalli N Rao | 2016 | International Journal of Ophthalmology(English edition)2016，9，5： | 1 |
| 9 | Models for multi-plant coordination显示文摘 | Rohit B and Pankaj C | 1993 | European Journal of operational Research1993，，67： | 1 |
| 10 | ediator role of veratryl alcohol in the lignin peroxidase-catalyzed oxidative decolorization of Remazol briuiant Blue R显示文摘 | Viral C Rohit S Dharmendra S | 2005 | Enzyme Microb Tech2005，36，4： | 1 |
| 11 | Research opportunities in service process design显示文摘 | Arthur V Hill David A Collier Craig M Froehle John C Goodale Richard D Metters Rohit Verma | 2002 | Journal of Operations Management2002，20，189： | 1 |
| 12 | Fermentation of biomass-generated producer gas to ethanol 显示文摘 | Rohit P D Rustin M S Bruno G C | 2004 | Biotechnology and Bioengineering2004，86，5： | 1 |
| 13 | Factors Affectionship Trust in Market Research Relationship 显示文摘 | ROHIT D MOORMAN C GETALD Z | 1993 | Journal of Marketing1993，，5： | 1 |
| 14 | Utilization of eye care services among those with unilateral visual impairment in rural South India:Andhra Pradesh Eye Disease Study(APEDS)显示文摘AIM:To report on the utilization of eye care services and its associated factors among those with unilateral visual impairment(VI)in a rural South Indian population.METHODS:A population based cross-sectional study was conducted in three districts(Adilabad,Mahbubnagar and West Godavari)in the state of Andhra Pradesh,India.A detailed interview and a comprehensive eye examination were conducted. Those with unilateral VI were asked questions about noticing any change in vision and on utilization of eye care services. The most important reason reported by the participant for not utilizing the services was used for the analysis. Multiple logistic regression models were used to examine the association between noticing a change in vision and socio-demographic variables such as age,gender,education and area of residence,severity and causes of VI.RESULTS:Among the 4456 participants aged ≥16y who were administered the questionnaire,53.2% were women,and 54.7% had no education. Of the 489(11%; 95% CI:10.1-11.9)people with unilateral VI,399(81.6%)participants reported noticing a change in their vision over the last five years but only 136(34.1%)participants had soughteye care consultation. Those who had any education(OR:1.9; 95% CI:1.1-3.2),had blindness(OR:2.7; 95% CI:1.4-5.2),and cataract(OR:2.1; 95% CI:1.0-4.3)as a cause of unilateral VI were more like to seek eye care consultations. The most commonly reported reasons for not seeking eye care services were 'do not have money for eye checkup' in 30.7% of the participants followed by 'do not have a serious problem'(30.0%).CONCLUSION:A large proportion of rural population though noticed a change in their vision did not seek eye care due to financial and person-related reasons. Eye care service providers need to address these barriers to enhance the uptake of eye care services among those with unilateral VI. | Srinivas Marmamula Giridhar Pyda Rohit C Khanna | 2017 | International Journal of Ophthalmology(English edition)2017，10，3： | 1 |
| 15 | Utility-directed resource allocation in virtual desktop clouds显示文摘 | PRASAD C ROHIT P ALEX B | | 0，，18： | 1 |
| 16 | Ediator role of veratryl alcohol in the lignin peroxidase catalyzed oxidative decolorization of Rem-azol briuiant Blue R显示文摘 | Viral C Rohit S Dharmendra S | | 0，，04： | 1 |
| 17 | Production,purification,characterization,and applications oflipases显示文摘 | Rohit?S Uttam C B | 2001 | Biotechnology Advances2001，19，： | 1 |
| 18 | Production, purification, characterization, and applications of lipases 显示文摘 | Rohit S Uttam C B | 2001 | Biotechnology Advances2001，19，62： | 1 |
| 19 | Production, purification, characterization, and applications of lipases 显示文摘 | Rohit S Uttam C B | 2001 | Biotechnol Ogy Advances2001，19，： | 1 |
| 20 | Models for multi-plant coordination显示文摘 | Rohit B and Pankaj C | 1993 | European Journal of Operational Research1993，，67： | 1 |
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