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21篇 您的检索式:作者名="Rohit G"
    题名 作者 年代 出处 被引量
1Combination immunotherapy with Survivin and luteinizing hormone-releasing hormone fusion protein in murine breast cancer model显示文摘AIM To investigate the therapeutic potential of two recombinant proteins, Survivin and luteinizing hormone-releasing hormone (LHRH) fusion protein [LHRH(6 leu)-LTB] for immunotherapy of breast cancer.METHODS Murine 4 T-1 breast cancer model was used to evaluate the efficacy of recombinant proteins in vivo. Twenty four Balb/c mice were divided into 4 groups of 6 mice each. Recombinant Survivin and LHRH fusion protein, alone or in combination, were administered along with immunomodulator Mycobacterium indicus pranii (MIP) in Balb/c mice. Unimmunized or control group mice were administered with phosphate buffer saline. Each group was then challenged with syngeneic 4 T-1 cells to induce the growth of breast tumor. Tumor growth was monitored to evaluate the efficacy of immune-response in preventing the growth of cancer cells.RESULTS Preventive immunization with 20 μg recombinant Survivin and MIP was effective in suppressing growth of 4 T-1 mouse model of breast cancer (P = 0.04) but 50 μg dose was ineffective in suppressing tumor growth. However, combination of Survivin and LHRH fusion protein was more effective in suppressing tumor growth (P = 0.02) as well as metastasis in vivo in comparison to LHRH fusion protein as vaccine antigen alone.CONCLUSION Recombinant Survivin and MIP suppress tumor growth significantly. Combining LHRH fusion protein with Survivin and MIP enhances tumor suppressive effects marginally which provides evidence for recombinant Survivin and LHRH fusion protein as candidates for translating the combination cancer immunotherapy approaches.Himani Garg Rohit Singh Hada Jagdish C Gupta G P Talwar Shweta Dubey 2018World Journal of Clinical Oncology2018,9,8:2
2Buffer management and rate guarantees for TCP/IP over satellite-ATM networks显示文摘ROHIT G RAJ J SONIA E 2001International Journal of Satellite Communications2001,19,1:1
3Preparation, characterization and electrical conductances of heterometallic coordi-nation polymers and complex bimetallic salts derived from isomaleonitrile- dithiolate 显示文摘NANHAI S SUNITA G ROHIT K S 2003Inorg Chem Commun2003,6,4:1
4A stability-indi- cating HPLC assay with diode array detection for the de- termination of a benzylpenicillin prodrug in aqueous so- lutions 显示文摘Jain Rohit Wu Zimei Tucker Ian G 2009Journal of Pharmaceutical and Biomedical A- nalysis2009,50,5:1
5Infectious complications following laparoscopic appendectomy 显示文摘Rohit G Cliff S Fahad B 2006Can J Surg2006,49,6:1
6Kinetics of electrooxidation of landfill leachate in a three-dimensional carbon bed electrochemical reactor 显示文摘RAO N N ROHIT M NITIN G 2009Chemosphere2009,76,:1
7Fermentation of biomass-generated producer gas to ethanol 显示文摘Rohit P D Rustin M S Bruno G C 2004Biotechnology and Bioengineering2004,86,5:1
8An overview of MIMO communication--A key to gigabit wireless显示文摘Arogyaswami J P Dhananjay A G Rohit U N 2004Proceedings of the IEEE2004,92,2:1
9Temperature in- duced stress influence on biodiesel productivity during mixotrophic microalgae cuhivation with wastewater 显示文摘Venkata Subhash G Rohit M V Devi M P 2014Bioresource Technolo- gy2014,169,:1
10Kinetics of electrooxidation of landfill leachate in a three-dimensional carbon bed electrochemical reactor 显示文摘Rao N N Rohit M Nitin G 2009Chemosphere2009,76,9:1
11Kinetics of electrooxidation of landfill leachate in a three-dimensional carbon bed electrochemical reactor 显示文摘RAO N ROHIT M NITIN G 2009Chemosphere2009,76,:1
12Kinetics of electrooxidation of landfill leachate in a three-dimension-al carbon bed electrochemical reactor显示文摘RAO N N ROHIT M NITIN G 2009Chemosphere2009,76,9:1
13A mechanistic model-based force-feedback scheme for voice-coil actuated radial contour turning显示文摘REDDY Rohit G Devor Richard E 2001International Journal of Machine Tools and Manufacture2001,41,8:1
14Mining genomlc databases to identify novel hydrogen producers 显示文摘Kalia V C Sadhana L Rohit G 2003Trends in Biotechnology2003,21,:1
15Comparative efficacy of desferriox-amine,deferiprone and in combination on iron chelation in thalas-semic children显示文摘SUNIL G ROHIT S NISHI M 2004Indian J Pediatr2004,41,1:1
16A mechanistic model-based force-feedback scheme for voice-coil actuated radial contour turning显示文摘REDDY ROHIT G DEVOR RICHARD E 2001International Journal of Machine Tools and Manufacture2001,41,8:1
17Comparison of numerical techniques used for simulating variable-density flow and transport experiments显示文摘Rohit R G Clement T P Joel H H 0,,02:1
18Hemangioperieytoma of Maxilla in a Pedi- atric Patient- A ease Report 显示文摘Rohit A Sonal G 2010J Dent Child2010,77,3:1
19Kinetics of electrooxidation of landfill leachate in a three-dimensional carbon bed electrochemi- cal reactor显示文摘Rao N N Rohit M Nitin G 2009Chemosphere2009,76,9:1
20Kinetics of electrooxidation of landfill leachate in a three-dimensional carbon bed electrochemical reactor显示文摘RAO N N ROHIT M NITIN G 2009Chemosphere2009,76,9:1
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