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| 1 | Colchicine reduces procollagen Ⅲ and increases pseudocholinesterase in chronic liver disease显示文摘AIM:To test whether colchicine would be an effective antif ibrotic agent for treatment of chronic liver diseases in patients who could not be treated with α-interferon.METHODS:Seventy-four patients(46 males,28 females) aged 40-66 years(mean 53±13 years) participated in the study.The patients were affected by chronic liver diseases with cirrhosis which was proven histologically(n=58);by chronic active hepatitis C(n=4),chronic active hepatitis B(n=2),and chronic persistent hepatitis C(n=6).In the four patients lacking histology,cirrhosis was diagnosed from anamnesis,serum laboratory tests,esophageal varices and ascites.Patients were assigned to colchicine(1 mg/d) or standard treatment as control in a randomized,double-blind trial,and followed for 4.4 years with clinical and laboratory evaluation.RESULTS:Survival at the end of the study was 94.6% in the colchicine group and 78.4% in the control group(P=0.001).Serum N-terminal peptide of type Ⅲ procollagen levels fell from 34.0 to 18.3 ng/mL(P=0.0001),and pseudocholinesterase levels rose from 4.900 to 5.610 mU/mL(P=0.0001) in the colchicine group,while no signif icant change was seen in controls.Best results were obtained in patients with chronic hepatitis C and in alcoholic cirrhotics.CONCLUSION:Colchicine is an effective and safe antifibrotic drug for long-term treatment of chronic liver disease in which fi brosis progresses towards cirrhosis. | Sergio Muntoni Marcos Rojkind Sandro Muntoni | 2010 | World Journal of Gastroenterology2010，16，23： | 14 |
| 2 | A simple micromethod for collagen and total protein determination in formalin- fixed paraffin- embedded sec- tions显示文摘 | L6pez - De Le6n A Rojkind M | 1985 | J Histochem Cytochem1985，33，8： | 1 |
| 3 | Regulation of monocyte chemoat-tractant protein-1 by cytokines and oxygen free radicals in rat hepatic fat-storing cells 显示文摘 | Xu Y Rojkind M Czaja MJ | 1996 | Gastroenterology1996，110，6： | 1 |
| 4 | 显示文摘 | Greenwel P Rojkind M | 1997 | Biochim Biophys Acta1997，136，2： | 1 |
| 5 | Repeated whiskey binges promote liver injury in rats fed a choline-deficient diet 显示文摘 | Nieto N Rojkind M | 2007 | J Hepatol2007，46，2： | 1 |
| 6 | Animal models of liver lqbrosis 显示文摘 | Rojkind M Greenwel P | 1993 | Adv Vet Sci Comp Med1993，37，： | 1 |
| 7 | Role of hydrogen peroxide and oxidative stress in healing responses显示文摘 | Rojkind M Dominguez-Rosales J A Nieto N | 2002 | Cell Mol Life Sci2002，59，： | 1 |
| 8 | Antibody-mediated autoimmune myocarditis depends on genetically determined target organ sensitivity显示文摘 | LIAO L I SINDHWANI R ROJKIND M | 1995 | J Exp Med1995，181，： | 1 |
| 9 | The blue glass and the predictive value of serum aminoterminal propertied of type Ⅲ procollagen as a marker of liver fibrosis 显示文摘 | Rojkind M | 1984 | Hepatology1984，4，： | 1 |
| 10 | Role of hydrogenperoxide and oxidative stress in healing responses显示文摘 | Rojkind M Domínguez-Rosales JA Nieto N | 2002 | Cell Mol LifeSci2002，59，： | 1 |
| 11 | Acetaldehyde increase procollagen type Ⅰ and fibronectin gen transcriptiong in cultured rat fat-storiug cell through a protein synthesis dependent mechanism显示文摘 | Casini A Cuningham M Rojkind M | 1991 | Hepatology1991，13，： | 1 |
| 12 | Role of hydrogen peroxide and oxidative stress in healing responses显示文摘 | Rojkind M Domi nguez-Rosales JA Nieto N | 2002 | Cell Mol Life Sci2002，59，11： | 1 |
| 13 | Antibody-mediat-ed autoimmune myocarditis depends on genetically deter-mined target organ sensitivity显示文摘 | Liao LI Sindhwani R Rojkind M | 1995 | J Exp Med1995，181，6： | 1 |
| 14 | A simple quantitative method for collagen typing in tissue samples: its application to human liver with schistosomiasis显示文摘 | Armendariz-Borunda J Rojkind M | 1984 | Coll Relat Res1984，4，1： | 1 |
| 15 | TGF ‐β1 Up‐Regulates the Expression of PDGF ‐β Receptor m RNA and Induces a Delayed PI 3 K ‐, AKT ‐, and p70<sup>S6K</sup>‐Dependent Proliferative Response in Activated Hepatic Stellate Cells显示文摘 | Ruchi Shah Karina Reyes‐Gordillo Jaime Arellanes‐Robledo Carmen G. Lechuga Zamira Hernández‐Nazara Adam Cotty Marcos Rojkind M. Raj Lakshman | 2013 | Alcohol Clin Exp Res2013，，11： | 1 |
| 16 | Liver collagen synthesis in murine schistosomiasis 显示文摘 | Weinter R Rojkind M Warren KS | 1987 | Biochemistry1987，18，4： | 1 |
| 17 | 墨西哥21世纪国家电影资料馆显示文摘电影有着连续移动和变化的特性,这点在它的英文"movingpictures"中有很好的体现,此次墨西哥电影资料馆的翻新和改造就体现出了该特性。随着科技的发展,不光图像可以在屏幕上移动,形成电影,连屏幕也可以在空间移动, | Michel Rojkind Gerardo Salinas 代照 | 2011 | 现代装饰2011，，11： | 0 |
| 18 | 月影传说显示文摘位于波兰科的Tori Tori餐厅被公认为是墨西哥城最好的日本餐厅,向来生意兴隆,宾客盈门。由于餐厅的巨大成功,如今的餐厅已搬到一处更加宽敞的场地。新餐厅由Rojkind Arquitectos和Esrawe Studio两家建筑事务所联袂打造。在波兰科的住宅区,各区域变化都很大,住宅楼不是被改造成了办公楼,就是餐厅。有时候改变总是在潜移默化地发生, | 徐进 Rojkind Arquitectos | 2012 | 建筑知识2012，，2： | 0 |
| 19 | 炫色常春藤 墨西哥Tori Tori餐厅显示文摘Tori Tori餐厅被认为是墨西哥城最好的日本餐厅。随着生意越来越好,原来的空间已经无法满足经营所需,于是餐厅择地重开,有了这家全新的炫目的Tori Tori餐厅。餐厅由当地的设计事务所Rojkind Arquitectos和Esrawe Studio联合设计,从周遭景观、到建筑和室内,再到家具,所有部分一气呵成。 | Rojkind arquitectos Esrawe Studio 和维 | 2012 | 室内设计与装修2012，，1： | 0 |
| 20 | 博卡里奥某音乐厅显示文摘就在哈马帕河最终汇入墨西哥湾的河口处,坐落着一处新建音乐大厅。这座音乐大厅的功能空间容身于多个大型的混凝土体量之中,而这些体量的分布看似十分随意.实则是经过精心设计的成果。从某些方面看来,这种设计与沿着建筑旁边的防波堤布置的巨型石块在形式上有一定的相似之处。 | Rojkind Arquitectos 王培(译) | 2018 | 建筑细部2018，16，3： | 0 |
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