|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Epidemiological Evolution of Lung Cancer in the South of Spain from 1990 to 2010显示文摘Background: Changes in lung cancer has been characterized by the increase of cases among women and the increase in adenocarcinomas among other histological subtypes.Methods: Descriptive analysis of cases diagnosed with lung cancer in Hospital Virgen de las Nieves(Spain) from 1990 to 2010,based on five variables(age, sex, smoking, histology and pathological anatomy). The study establishes associations between these variables and compares the results with the literature.Results: 2,026 patients were diagnosed with lung cancer in this period; 1,838 were males(90.7%) and 188 women(9.3%); 1,892 patients(93.4%) were smokers or ex-smokers and 134(6.6%) had never smoked; the most frequent non-small cell histology types were squamous cell carcinoma and adenocarcinoma and it was the most frequent neoplasia in women and were associated with a lower tobacco consumption.Conclusion: The large majority of lung cancer cases is associated with a history of smoking tobacco and there are histopathological differences according to gender and cumulative tobacco smoke load. | Alberto Caballero Vázquez Ana Dolores Romero Ortiz Jose Manuel González de Vega San Román Raimundo García del Moral Bernardino Alcázar Navarrete | 2018 | 中国肺癌杂志2018，21，1： | 17 |
| 2 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 3 | Nutritional therapy for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most frequent primary liver cancer and presents together with cirrhosis in most cases.In addition to commonly recognized risk factors for HCC development,such as hepatitis B virus/hepatitis C virus infection,age and alcohol/tobacco consumption,there are nutritional risk factors also related to HCC development including high intake of saturated fats derived from red meat,type of cooking(generation of heterocyclic amines)and contamination of foods with aflatoxins.On the contrary,protective nutritional factors include diets rich in fiber,fruits and vegetables,n-3 polyunsaturated fatty acids and coffee.While the patient is being evaluated for staging and treatment of HCC,special attention should be paid to nutritional support,including proper nutritional assessment and therapy by a multidisciplinary team.It must be considered that these patients usually develop HCC on top of long-lasting cirrhosis,and therefore they could present with severe malnutrition.Cirrhosisrelated complications should be properly addressed and considered for nutritional care.In addition to traditional methods,functional testing,phase angle and computed tomography scan derived skeletal muscle index-L3 are among the most useful tools for nutritional assessment.Nutritional therapy should be centered on providing enough energy and protein to manage the increased requirements of both cirrhosis and cancer.Supplementation with branched-chain amino acids is also recommended as it improves response to treatment,nutritional status and survival,and finally physical exercise must be encouraged and adapted to individual needs. | Astrid Ruiz-Margáin Berenice M Román-Calleja Paulina Moreno-Guillén JoséA González-Regueiro DeyaniraKúsulas-Delint Alejandro Campos-Murguía Nayelli C Flores-García Ricardo Ulises Macías-Rodríguez | 2021 | World Journal of Gastrointestinal Oncology2021，13，10： | 4 |
| 4 | Plant Growth-Promoting Traits in Rhizobacteria of Heavy Metal-Resistant Plants and Their Effects on Brassica nigra Seed Germination显示文摘Phytoremediation is an emerging technology that uses plants and their associated microbes to clean up pollutants from the soil, water, and air. In order to select the plant growth-promoting rhizobacteria(PGPR) for phytoremediation of heavy metal contamination, 60 bacterial strains were isolated from the rhizosphere of two endemic plants, Prosopis laevigata and Spharealcea angustifolia, in a heavy metal-contaminated zone in Mexico. These rhizobacterial strains were characterized for the growth at different pH and salinity, extracellular enzyme production, solubilization of phosphate, heavy metal resistance, and plant growth-promoting(PGP) traits, including production of siderophores and indol-3-acetic acid(IAA). Overall, the obtained rhizobacteria presented multiple PGP traits. These rhizobacteria were also resistant to high levels of heavy metals(including As as a metalloid)(up to 480 mmol L(-1)As(V), 24 mmol L(-1)Pb(Ⅱ), 21 mmol L(-1)Cu(Ⅱ), and 4.5 mmol L(-1)Zn(Ⅱ)). Seven rhizobacterial strains with the best PGP traits were identified as members of Alcaligenes, Bacillus, Curtobacterium, and Microbacterium, and were selected for further bioassay.The inoculation of Brassica nigra seeds with Microbacterium sp. CE3R2, Microbacterium sp. NE1R5, Curtobacterium sp. NM1R1,and Microbacterium sp. NM3E9 facilitated the root development; they significantly improved the B. nigra seed germination and root growth in the presence of heavy metals such as 2.2 mmol L(-1)Zn(Ⅱ). The rhizobacterial strains isolated in the present study had the potential to be used as efficient bioinoculants in phytorremediation of soils contaminated with multiple heavy metals. | Brenda ROMN-PONCE Diana Miryel REZA-VZQUEZ Sonia GUTIRREZ-PAREDES María de Jesús DE HARO-CRUZ Jessica MALDONADO-HERNNDEZ Yanely BAHENA-OSORIO Paulina ESTRADA-DE LOS SANTOS En Tao WANG María Soledad VSQUEZ-MURRIETA | 2017 | Pedosphere2017，27，3： | 4 |
| 5 | Heparanase: a new metastasis-associated antigen recognized in breast cancer patients by spontaneously induced memory T lymphocytes显示文摘 | Sommerfeldt N Beckhove P Ge Y Sehutz F Choi C Bucur M Domsehke C Sohn C Sehneeweis A Rom J Poll- mann D Leneht D Vlodavsky I Sehirrmaeher V | 2006 | Cancer Res2006，66，15： | 1 |
| 6 | Continuous positive airway pressure in sleep apnea prevents new vascular events after ischemic stroke显示文摘 | Martínez-García MA Galiano-Blancart R Román-Sánchez P | | 0，，： | 1 |
| 7 | Methylenetetrahydrofolate reductase gene polymorphisms in black South Africans and the association with preeclampsia显示文摘 | Pegoraro RJ Chikosi A Rom L | 2004 | Acta Obstet Gynecol Scand2004，83，5： | 1 |
| 8 | Distributed shortest path protocols for time- dependent networks 显示文摘 | Orda A Rom R | 1996 | Distributed Computing1996，10，1： | 1 |
| 9 | Wnt- signaling pathway in ovarian epithelial tumours :increased expres-sion of beta-catenin and GSK3 beta显示文摘 | Rask K Nilsson A Brannst Rom M | 2003 | Br J Cancer2003，89，13： | 1 |
| 10 | Cyclodextrin-Modified Gold Nanospheres显示文摘 | Liu J Ong W Román E Lynn M J Kaifer A E | 2000 | Langmuir2000，16，： | 1 |
| 11 | Subcortical ischaemic vascular dementia显示文摘 | Román GC Erkinjuntti T Wallin A | 2002 | Lancet Neurol2002，1，7： | 1 |
| 12 | The role of MAPK signal transduction pathways in the response to oxidative stress in the fungal pathogen Candida albicans: implications in virulence 显示文摘 | de Dios C H Rom(m E Monge R A | 2010 | Curr Protein Pept Sci2010，11，8： | 1 |
| 13 | Purity control of F1 - hybrid tomato cultivars by RAPD markers 显示文摘 | Rom M Bar M Rom A | 1995 | Plant Breeding1995，114，： | 1 |
| 14 | 显示文摘 | Saikku A Ckst Rom B A Tulamo R M | 1999 | Journal of Materi- als Science: Materials in Medicine1999，10，1： | 1 |
| 15 | Purity control of F1-hybrid tomato cultivars by RAPD markers显示文摘 | Rom M Bar M Rom A | 1995 | Plant Breeding1995，114，： | 1 |
| 16 | Shortest-path and mininum delay algorithms in networks with time-dependent eddge-length显示文摘 | ORDA A ROM R | | 0，，03： | 1 |
| 17 | MicroRNA expression profiling in Imatinib-resistant chronic myeloid leukemia patients without clinically significant ABL1-mutations显示文摘 | SAN JOS(E) EN(E)RIZ E ROM(A)N G(O)MEZ J JIM(E)NEZ VELASCO A | | 0，，： | 1 |
| 18 | Field water drainage under traditional and improved irrigation schedules for corn in central Spain显示文摘 | Román R Caballero R Bustos A | 1999 | Soil Science Society of America Journal1999，63，： | 1 |
| 19 | MicroRNA expressionprofiling in imatinib-resistant chronic myeloid leukemia patients without clinically significant ABL1-mutations显示文摘 | San José-Enériz E Román-Gómez J Jiménez-Velasco A | | 0，，01： | 1 |
| 20 | Competitive routing in multiuser communication networks显示文摘 | ORDA A ROM R | 1993 | IEEE/ACM Trans on Networking1993，1，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员