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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Frequency control in competitive electricity market dispatch显示文摘 | Ronan Doherty Gillian Lalor Malley M O | 2005 | IEEE Trans on Power Systems2005，20，3： | 1 |
| 3 | Relationship between hip dysplasia, pain, and osteoarthritis in a cohort of patients with hip symptoms显示文摘 | JOHANNE M RONAN B BERNARD M | 2013 | J Rheumatol2013，40，9： | 1 |
| 4 | Measurement of phthalates diesters in food using gas chromatography-tandem mass spectrometry显示文摘 | RONAN C FREDERIC L FABRICE M | 2016 | Food Chem2016，196，： | 1 |
| 5 | Evidence that a locus for familial high myopia maps to chromosome 18p显示文摘 | Ronan S M Drahozal L A | 1998 | Am J Hum Genet1998，63，1： | 1 |
| 6 | A new approach to quantify reserve demand in systems with significant installed wind capacity 显示文摘 | Ronan D Mark O M | 2005 | IEEE Trans on Power Systems2005，20，2： | 1 |
| 7 | The green initiative: improving quality and competitiveness for European SMEs显示文摘 | Kate G Paul H Ronan M | 1997 | European Business Review1997，97，5： | 1 |
| 8 | New muhiersidue analytical method dedicated to trace level measurement of borminated flameretardants in human biological matrices 显示文摘 | RONAN C JEAN P A PHILIPPE M | 2005 | J Chonnatogr A2005，1100，： | 1 |
| 9 | Efficient collision detection with in deforming spherical sliding contact 显示文摘 | Anderson M Ronan B Daniel T | 2007 | IEEE Transactions on Visualization and Computer Graphics2007，13，3： | 1 |
| 10 | Coagulopathy, catecholamines and biomarkers of endothelial damage in experimental human endotoxemia and in patients with severe sepsis. A prospective study显示文摘 | Sisse R. Ostrowski Ronan M.G. Berg Nis A. Windel?v Martin A.S. Meyer Ronni R. Plovsing Kirsten M?ller P?r I. Johansson | 2013 | Journal of Critical Care2013，，： | 1 |
| 11 | Textural properties of fruit affected by experimental conditions in TPA test: an RSM ap- proach 显示文摘 | Emmanuel M Ronan S Emira M | 2011 | International Journal of Food Science and Technol- ogy2011，，46： | 1 |
| 12 | A second locus for familial high myopia maps to chromosome 12q显示文摘 | Ronan S M Alvear A B | 1998 | Am J Hum Genet1998，63，5： | 1 |
| 13 | Evi- dence that a locus for familial high myopia maps to chro- mosome 18p显示文摘 | YOUNG T L RONAN S M DRAHOZAL L A | 1998 | Am J Hum Genet1998，63，1： | 1 |
| 14 | A second locus for familial high myopia maps to chromosome 12q 显示文摘 | YOUNG T L RONAN S M ALVEAR A B | 1998 | Am J Hum Genet1998，63，5： | 1 |
| 15 | Frequency control in competitive electricity market dispatch显示文摘 | Ronan D Gillian L Malley M O | 2005 | IEEE Transactions on Power Systems2005，20，3： | 1 |
| 16 | A spice ii subcircuit representation for power mosfets using empirical methods显示文摘 | Dolny G M Ronan J H R Wheatley J C F | | 0，，： | 1 |
| 17 | Frequency control in competitive electricity market dispatch显示文摘 | RONAN D GILLIAN L MALLEY M O | 2005 | IEEE Transactions on Power Systems2005，20，3： | 1 |
| 18 | An adapter ligation-mediated PCR method for high-throughput mapping of T-DNA inserts in the Arabidopsis genome显示文摘 | Ronan C O Jose M A Christopher J K | 2007 | Nature Protocols2007，2，11： | 1 |
| 19 | Containing synthetic polymers:Advancing biomimicry via controlled synthesis and self-assembly显示文摘 | Ronan M O’Reilly R Nucleobase K | 2012 | Macromolecules2012，45，19： | 1 |
| 20 | Building buildings 显示文摘 | Ronan M A Tits J | 1987 | Math Annalen1987，278，： | 1 |
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