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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | N:w locus for autosomal dominanthigh myopia maps to the long arm of chromosome 17显示文摘 | Paluru P Ronan SM Heon E | 2003 | Invest Ophthalmol Vis Sci2003，44，5： | 1 |
| 3 | New muhiersidue analytical method dedicated to trace level measurement of borminated flameretardants in human biological matrices 显示文摘 | RONAN C JEAN P A PHILIPPE M | 2005 | J Chonnatogr A2005，1100，： | 1 |
| 4 | Enteral and parenteral nutrition for critically ill patients:A logical combination to optimize nutritional support显示文摘 | Claude P Ronan T Claudia-Paula H | | 0，，01： | 1 |
| 5 | Coagulopathy, catecholamines and biomarkers of endothelial damage in experimental human endotoxemia and in patients with severe sepsis. A prospective study显示文摘 | Sisse R. Ostrowski Ronan M.G. Berg Nis A. Windel?v Martin A.S. Meyer Ronni R. Plovsing Kirsten M?ller P?r I. Johansson | 2013 | Journal of Critical Care2013，，： | 1 |
| 6 | Predicting mortality in patients with community-acquired pneumonia and low CURB-65 scores显示文摘 | Ronan D Nathwani D Davey P | 2010 | Eur J Clin Microbiol Infect Dis2010，29，9： | 1 |
| 7 | Development of home educational materials for families of preterm infants显示文摘 | Ronan S Liberatos P Weingarten S | 2015 | Neonatal Netw2015，34，2： | 1 |
| 8 | Retinal pigment epithelium tears after intravitreal injection of bevaeizumab (avastin) for neovaseular age-related macular degeneration 显示文摘 | Ronan SM Yoganathan P Chien FY | 2007 | Retina2007，27，5： | 1 |
| 9 | New locus for auto- soma显示文摘 | PALURU P RONAN SM HEON E eta | 2003 | Invest Ophthalmol Vis Sci2003，44，5： | 1 |
| 10 | Acupuncture for schizophrenia: a systematic review and meta-analysis显示文摘 | Lee MS Shin BC Ronan P Ernst E | 2009 | Int J Clin Pract2009，63，11： | 1 |
| 11 | Homework Assignments in Cognitive and Behavioral Therapy: A Meta-analysis 显示文摘 | KAZANTZIS N DEANE F P RONAN K R | 2000 | Clinical Psychology: Science and Practice2000，7，2： | 1 |
| 12 | In vivo metabolism of a mutant form of apolipoproteinA-I,apoA-IMilano,associated with familial hypoalphalipoproteinemia1显示文摘 | Gregg RE Meng MS Ronan R Zech LA Franceschini G | 1993 | J Clin Invest1993，91，4： | 1 |
| 13 | Predicting mor- tality in patients with community-acquired pneumonia and low CURB-65 scores 显示文摘 | Ronan D Nathwani D Davey P | 2010 | Eur J Clin Microbiol Infect Dis2010，29，9： | 1 |
| 14 | The Reliability and Validity of the Critical Incident Technique: A Closer Look 显示文摘 | Ronan W W Gary P L | 1974 | Studies in Personnel Psychology1974，6，1： | 1 |
| 15 | The reliability and validity of the critical incident technique:A closer look显示文摘 | Ronan W W Latham G P | 1974 | Studies in Personnel Psychology1974，6，1： | 1 |
| 16 | New locus for autosomal dominant high myopia maps to the long arm of chromosome 17显示文摘 | Paluru P Ronan SM Heon E | 2003 | Invest Ophthalmol Vis Sci2003，44，5： | 1 |
| 17 | New locus for autoscmal dominant high myopia maps to the long arm of chromosome显示文摘 | Paluru P Ronan SM Heen E | | 0，，5： | 1 |
| 18 | New locus for autosomal dominant high myopia maps to the long arm of chromosome 17显示文摘 | Paluru P Ronan SM Heon E Devoto M Wildenberg SC Scavello G | 2003 | Invest Ophthalmol Vis Sci2003，44，5： | 1 |
| 19 | New locus for autosomal dominant high myopia maps to the long arm of chromosome 17 显示文摘 | Paluru P Ronan SM Heon E | 2003 | Invest Ophthalmol Vis Sci2003，44，5： | 1 |
| 20 | Acupuncture and schizophrenia: choices for collecting evidence: limitations and significance显示文摘 | Ronan P Robinson N Harbinson D MacInnes D | 2010 | Eur J Orient Med2010，6，5： | 1 |
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