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| 1 | Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis显示文摘AIM To determine the effect of combined serelaxin and rosiglitazone treatment on established hepatic fibrosis.METHODS Hepatic fibrosis was induced in mice by carbon tetrachloride administration for 6 wk, or vehicle alone(nonfibrotic mice). For the final 2 wk, mice were treated with rosiglitazone, serelaxin, or both rosiglitazone and serelaxin. Serum liver enzymes and relaxin levels were determined by standard methods. The degree of liver collagen content was determined by histology and immunohistochemistry. Expression of type?Ⅰ?collagen was determined by quantitative PCR. Activation of hepatic stellate cells was assessed by alpha-smoothmuscle actin(SMA) levels. Liver peroxisome proliferator activated receptor-gamma coactivator 1 alpha(PGC1α) was determined by Western blotting.RESULTS Treatment of mice with CCl4 resulted in hepatic fibrosis as evidenced by increased liver enzyme levels(ALT and AST), and increased liver collagen and SMA. Monotherapy with either serelaxin or rosiglitazone for 2 wk was generally without effect. In contrast, the combination of serelaxin and rosiglitazone resulted in significantly improved ALT levels(P < 0.05). Total liver collagen content as determined by Sirius red staining revealed that only combination treatment was effective in reducing total liver collagen(P < 0.05). These results were supported by immunohistochemistry for type?Ⅰ?collagen, in which only combination treatment reduced fibrillar collagen levels(P < 0.05). The level of hepatic stellate cell activation was modestly, but significantly, reduced by serelaxin treatment alone, but combination treatment resulted in significantly lower SMA levels. Finally, while hepatic fibrosis reduced liver PGC1α levels, the combination of serelaxin and rosiglitazone resulted in restoration of PGC1α protein levels.CONCLUSION The combination of serelaxin and rosiglitazone treatment for 2 wk was effective in significantly reducing established hepatic fibrosis, providing a potential new treatment strategy. | Robert G Bennett Ronda L Simpson Frederick G Hamel | 2017 | World Journal of Gastroenterology2017，23，22： | 2 |
| 2 | Antineutrophil cytoplasmantibodies (ANCA) of IgA isotype in adult Henoch-Sch6nlein purpura显示文摘 | Ronda N Esnault VL Layward L | | 0，，： | 1 |
| 3 | Preparation, Thermal Properties and Flame Retardancy of Phosphorus and Silicon-containing Epoxy Resins显示文摘 | Sponton M Mercado L A Ronda J C | 2008 | Polymer Degradation and Stability2008，93，11： | 1 |
| 4 | Preparation, thermal properties and flame retardancy of phosphorus - and silicon -containing epoxy resins 显示文摘 | SPONTON M MERCADO L A RONDA J C | 2008 | Polymer Degradation and Stability2008，93，11： | 1 |
| 5 | Prepara- tion, Thermal Properties and Flame Retardancy of Phos- phorus- and Silicon-containing Epoxy Resins显示文摘 | Sponton M Mercado L A Ronda J C | 2008 | Polymer Degradation and Stability2008，93，11： | 1 |
| 6 | Preparation,thermal properties and flame retardancy of phosphorus-and silicon-containing epoxy resins显示文摘 | Sponton M Mercado L A Ronda J C | | 0，，11： | 1 |
| 7 | Fatty acid derived phosphorus-containing polyesters via acyclic diene metathesis polymerization 显示文摘 | ESPINOSA L M D RONDA J C GALIA M | 2009 | Journal of Polymer Science Part A: Polymer Chemistry2009，47，21： | 1 |
| 8 | Preparation, thermal properties and flame retardancy of phosphorusand silicon-containing epoxy resins显示文摘 | SPONToN M MERCADO L A RONDA J C | 2008 | Polymer Degradation and Stability2008，93，11： | 1 |
| 9 | Searching for Autolysin functions :Characterization of Pneumococal Mutant Deleted in the lyt A Gene显示文摘 | Sanchez P J M Ronda C Garcia J L | 1986 | Eur J Biochem1986，158，： | 1 |
| 10 | Protein crystal microspectrophotometry显示文摘 | Ronda L Bruno S Bettati S | | 0，，： | 1 |
| 11 | Antineutrophil cytoplasm antibodies (ANCA) of IgA isotype in adult Henoch-Schinlein purpura显示文摘 | Ronda N Esnault VL Layward L | 1994 | Clin Exp Immunol1994，95，1： | 1 |
| 12 | Preparation thermal properties and flame retardancy of phosphorus-and silicon-containing epoxy resins显示文摘 | Sponton M Mercado L A Ronda J C | 2008 | Polymer Degradation and Stability2008，93，11： | 1 |
| 13 | Bionanocomposites from renewable resources: epoxidized linseed oil-polyhedral oligomeric silsesquioxanes hybrid materials显示文摘 | L L Igadas G Ronda J C Gal I A M | 2006 | Biomacromol2006，7，： | 1 |
| 14 | Preparation, thermal properties and flame retardancy of phosphoru- and siliconcontaining epoxy resins 显示文摘 | Sponton M Mercado L A Ronda J C | 2008 | Polymer Degradation and Stability2008，93，11： | 1 |
| 15 | Preparation, thermal properties and flame retardancy of phosphorus- and silicon-containing epoxy resins显示文摘 | Sponton M Mercado L A Ronda J C | 2008 | Polym Degrad Stab2008，93，11： | 1 |
| 16 | Role of 17β- estradiol and testosterone in apoptosis显示文摘 | Vaseonsuelo A Pronsato L Ronda AC | 2011 | Steroids2011，76，12： | 1 |
| 17 | Dynamics of the evolution of the strategy concept 1962-2008 : a co-word a- nalysis 显示文摘 | RONDA PUPO G A GUERRAS MARTIN L A | 2012 | Strategic Management Journal2012，33，2： | 1 |
| 18 | Prep- aration, thermal properties and flame retardancy of phosphor- us- and silicon-containing epoxy resins 显示文摘 | SPONTON M MERCADO L A RONDA J C | 2008 | Polym Degrad Stab2008，93，11： | 1 |
| 19 | Oxymcin during myomectomy:a randomized study显示文摘 | Agostini A Ronda l Franchi F et aI | 2005 | Eur J ObstetGynecolEeprodBiol2005，118，2： | 1 |
| 20 | Haemoglobin - based oxygen carriers: research and reality towards an al- ternative to blood transfusions 显示文摘 | Mozzarelli A Ronda L Faggiano S | 2010 | Blood Transfus2010，8，3： | 1 |
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