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| 1 | Increased presence of effector lymphocytes during Helicobacter hepaticus-induced colitis显示文摘AIM:To identify and characterize drosophila mothers against decapentaplegic(SMAD)3-dependent changes in immune cell populations following infection with Helicobacter hepaticus(H.hepaticus).METHODS:SMAD3 -/-(n=19)and colitis-resistant SMAD3+/-(n=24)mice(8-10 wk of age)were in-fected with H.hepaticus and changes in immune cell populations[T lymphocytes,natural killer(NK)cells,T regulatory cells]were measured in the spleen and mesenteric lymph nodes(MsLNs)at 0 d,3 d,7 d and 28 d post-infection using flow cytometry.Genotypedependent changes in T lymphocytes and granzyme B+ cells were also assessed after 28 d in proximal colon tissue using immunohistochemistry.RESULTS:As previously observed,SMAD3 -/-,but not SMAD3+/-mice,developed colitis,peaking at 4 wk post-infection.No significant changes in T cell subsets were observed in the spleen or in the MsLNs between genotypes at any time point.However,CD4+and CD8+/ CD62Llo cells,an effector T lymphocyte population,as well as NK cells(NKp46/DX5+)were significantly higher in the MsLNs of SMAD3-/-mice at 7 d and 28 d post-infection.In the colon,a higher number of CD3+cells were present in SMAD3-/-compared to SMAD3+/-mice at baseline,which did not significantly change during infection.However,the number of granzyme B+cells,a marker of cytolytic lymphocytes,significantly increased in SMAD3-/-mice 28 d post-infection compared to both SMAD3+/-mice and to baseline values.This was consistent with more severe colitis development in these animals.CONCLUSION:Data suggest that defects in SMAD3 signaling increase susceptibility to H.hepaticus-induced colitis through aberrant activation and/or dysregulation of effector lymphocytes. | Sarah J McCaskey Elizabeth A Rondini Jonathan F Clinthorne Ingeborg M Langohr Elizabeth M Gardner Jenifer I Fenton | 2012 | World Journal of Gastroenterology2012，18，13： | 2 |
| 2 | Vanadium pentoxide induces pulmonary imflammation and tumor promotion in a strain dependent manner显示文摘 | RONDINI E A WALTERS D M BAUER A K | | 0，，： | 1 |
| 3 | Bound ferulic acid from bran is more bioavailable than the free compound in rat显示文摘 | Rondini L Peyrat-Maillard MN Marsset-Baglieri A | | 0，，13： | 1 |
| 4 | Sulfated ferulic acid is the main in vivo metabolite found after short-term ingestion of free ferulic acid in rats显示文摘 | Rondini L Peyrat-Maillard M N Marsset-Baglieri A | | 0，，10： | 1 |
| 5 | Deficiency of neutrophil phagocytosis in premature infants: effect of vitamin E supplementation 显示文摘 | Chirico G Marconi M Colombo A Chiara A Rondini G Ugazio AG | 1983 | Acta Paeditr Scand1983，72，4： | 1 |
| 6 | Bound ferulic acid from bran is more bioavailable than the free compound in rat显示文摘 | Rondini L Peyrat-Maillard M N Marsset-Baglieri A | 2004 | Journal of Agricultural and Food chemistry2004，52，： | 1 |
| 7 | Bound ferulic acid from bran is more bioavailable than the free compound in rat显示文摘 | RONDINI L PEYRAT-MAILLARD M N MARSSET-BAGLIERI A | 2004 | Journal of Agricultural and Food Chemistry2004，52，13： | 1 |
| 8 | Bound ferulic acid from bran is more bioavailable than the free compound in rat显示文摘 | Rondini L Peyrat-Mailard MN Marsset-Baglieri A | 2005 | Journal of Agricultural and Food Chemistry2005，52，： | 1 |
| 9 | Reconstruction of calcaneal skeletal defects caused by trauma显示文摘 | Fortina A Bertone C Rondini A | 1998 | J Foot Ankle Surg1998，37，5： | 1 |
| 10 | Differential effects of energy balance on experimentally-induced colitis显示文摘AIM:To characterize the influence of diet-induced changes in body fat on colitis severity in SMAD3-/mice.METHODS:SMAD3-/-mice (6-8 wk of age) were randomly assigned to receive a calorie restricted (30% of control;CR),control (CON),or high fat (HF) diet for 20 wk and were gavaged with sterile broth or with Helicobacter hepaticus (H.hepaticus) to induce colitis.Four weeks after infection,mice were sacrificed and the cecum and colons were processed for histological evaluation.RESULTS:Dietary treatment significantly influenced body composition prior to infection (P < 0.05),with CR mice having less (14% ± 2%) and HF-fed mice more body fat (32% ± 7%) compared to controls (22% ±4%).Differences in body composition were associated with alterations in plasma levels of leptin (HF > CON > CR) and adiponectin (CON > HF ≥ CR) (P < 0.05).There were no significant differences in colitis scores between CON and HF-fed mice 4 wk post-infection.Consistent with this,differences in proliferation and inflammation markers (COX-2,iNOS),and infiltrating cell types (CD3 + T lymphocytes,macrophages) were not observed.Unexpectedly,only 40% of CR mice survived infection with H.hepaticus,with mortality observed as early as 1 wk following induction of colitis. | Sarah J McCaskey Elizabeth A Rondini Ingeborg M Langohr Jenifer I Fenton | 2012 | World Journal of Gastroenterology2012，18，7： | 0 |
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