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| 1 | Hypothalamic-pituitary-adrenal axis hyperactivity accounts for anxiety-and depression-like behaviors in rats perinatally exposed to bisphenol A显示文摘Accumulating studies have proved that perinatal exposure to environmental dose causes long-term potentiation in anxiety/depression-related behaviors in rats.Hyperactivity of the hypothalamic-pituitary-adrenal(HPA) axis is one of the most consistent biological findings in anxiety- and depression-related disorders.The HPA axis is reported to be susceptible to developmental reprogramming.The present study focused on HPA reactivity in postnatal day(PND) 80 male rats exposed perinatally to environmental-dose BPA.When female breeders were orally administered 2 μg/(kg.day) BPA from gestation day 10 to lactation day 7,their offspring(PND 80 BPA-exposed rats)showed obvious anxiety/depression-like behaviors.Notably,significant increase in serum corticosterone and adrenocorticotropin,and corticotropin-releasing hormone mRNA were detected in BPA-exposed rats before or after the mild stressor.Additionally,the level of glucocorticoid receptor mRNA in the hippocampus,but not the hypothalamus,was decreased in BPA-exposed rats.The levels of hippocampal mineralocorticoid receptor mRNA,neuronal nitric oxide synthase and phosphorylated cAMP response element binding protein were increased in BPA-exposed rats.In addition,the testosterone level was in BPA-exposed rats.The results indicate that reprogramming-induced hyperactivity of the HPA axis is an important link between perinatal BPA exposure and persistent potentiation in anxiety and depression. | Fang Chen Libin Zhou Yinyang Bai Rong Zhou Ling Chen | 2015 | The Journal of Biomedical Research2015，29，3： | 17 |
| 2 | Global convergence of delayed dynamical systems显示文摘 | Lu Wenlian Rong libin Chen Tianping | 2003 | International Journal of Neural Systems2003，13，1： | 1 |
| 3 | Modeling HIV persistence,the latent reservoir and viral blips显示文摘 | Rong Libin Perelson Alan S | 2009 | Journal of Theoretical Biology2009，260，： | 1 |
| 4 | Berberine attenuates cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytes显示文摘 | Libin Zhou Xiao Wang Ying Yang Ling Wu Fengying Li Rong Zhang Guoyue Yuan Ning Wang Mingdao Chen Guang Ning | 2010 | BBA - Molecular Basis of Disease2010，，4： | 1 |
| 5 | Delay-independent stability analysis of Cohen-Grossberg neural networks显示文摘 | Chen Tianping Rong Libin | 2003 | Physics Letters A2003，317，： | 1 |
| 6 | Robust global exponential stability of Cohen-Grossberg neural networks with time delays显示文摘 | Chen T P Libin Rong | 2004 | Neural Networks2004，15，： | 1 |
| 7 | A model of HIV-1 infection with two time delays: Mathematical analysis and comparison with patient data显示文摘 | Kasia A. Pawelek Shengqiang Liu Faranak Pahlevani Libin Rong | 2011 | Mathematical Biosciences2011，，1： | 1 |
| 8 | Delay-independent stability analysis Cohen-Grossberg neural networks 显示文摘 | Chen Tianping Rong Libin | 2003 | Physics Letters A2003，317，56： | 1 |
| 9 | A delayed reaction–diffusion viral infection model with nonlinear incidences and cell-to-cell transmission显示文摘In this paper,we propose a reaction–diffusion viral infection model with nonlinear incidences,cell-to-cell transmission,and a time delay.We impose the homogeneous Neumann boundary condition.For the case where the domain is bounded,we first study the well-posedness.Then we analyze the local stability of homogeneous steady states.We establish a threshold dynamics which is completely characterized by the basic reproduction number.For the case where the domain is the whole Euclidean space,we consider the existence of traveling wave solutions by using the cross-iteration method and Schauder’s fixed point theorem.Finally,we study how the speed of spread in space affects the spread of cells and viruses.We obtain the existence of the wave speed,which is dependent on the diffusion coefficient. | Qing Ge Xia Wang Libin Rong | 2021 | International Journal of Biomathematics2021，14，8： | 0 |
| 10 | Effects of 80 MeV/u ^(12)C^(6+) Ion Radiation Mouse Head on Immunity Cell Cycle Distributions显示文摘After whole head irradiation (WHI) of mice with heavy ions, we study the changes of cycle distribution of bone marrow, spleen and peripheral lymphocyte cells, and the aim is to provide basic data for space radiation protection and biological object oriented ion therapy. The heads of the BALB/c mice were irradiated with 0, 0. 5, 1,2, 4 or 10 Gy by 12C6+ ions (80 MeV/u, 1 Gy/min) and then the cell cycle distribu- | Bing Tao, Dang Bingrong, Xie Yi, Li Wenjian,Ma Qiufeng, Wang Jufang, Qiu Rong Zhou Libin, Guo Chuanling,Jing Xigang, Zhang Hong, Li Qiang Yuan Zhigang and Ma Shuang | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 11 | Research and Development of Butterfly Microfluidic Gene Chip for 19 Common Pathogenic Microorganisms of Nosocomial Infection显示文摘Based on butterfly microfluidic gene chip technology,a method for rapid,accurate and efficient detection of 19 common pathogenic microorganisms of nosocomial infection was established,and a butterfly microfluidic gene chip with high-throughput detection was designed and fabricated.Using constant temperature amplification technology,using the polymerase with chain replacement function to react at constant temperature(65℃)and combined with microfluidic chip technology,primers were designed according to the target genes of 19 pathogenic microorganisms,and a butterfly microfluidic gene chip which can detect 19 common pathogenic microorganisms of nosocomial infection was made to simplify the inspection operation process and verify the sensitivity of the chip.The butterfly microfluidic gene chip can be used for the rapid and efficient detection of 19 common pathogenic microorganisms of nosocomial infection,and provides a new idea for the detection and auxiliary diagnosis of pathogenic microorganisms of nosocomial infection. | Jingjing Yu Xu Zhang Jinhai Tian Rong Ma Qi Huang Jia Cao Jia Wang Libin Wang | 2022 | Journal of Clinical and Nursing Research2022，6，1： | 0 |
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