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您的检索式：作者名="Rongyang Xu"
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| 1 | Targeting the ferroptosis crosstalk:novel alternative strategies for the treatment of major depressive disorder显示文摘Depression is a major contributor to poor global health and disability,with a recently increasing incidence.Although drug therapy is commonly used to treat depression,conventional antidepressant drugs have several disadvantages,including slow onset,low response rates and severe adverse effects.Therefore,developing effective therapies for depression remains challenging.Although various aetiological theories of depression exist,the underlying mechanisms of depression are complex,and further research is crucial.Moreover,oxidative stress(OS)-induced lipid peroxidation has been demonstrated to trigger ferroptosis.Both OS and ferroptosis are pivotal mechanisms implicated in the pathogenesis of neurological disorders,and investigation of the mediators involved in these processes has emerged as a prominent and active research direction.One previous study revealed that regulatory proteins involved in ferroptosis are implicated in the pathogenesis of depression,and antidepressant drugs could reverse depressive symptoms by inhibiting ferroptosis in vivo,suggesting an important role of ferroptosis in the pathogenesis of depression.Hence,our current comprehensive review offers an up-to-date perspective on the intricate mechanisms involved,specifically concerning ferroptosis and OS in the context of depression,along with promising prospects for using molecular mediators to target ferroptosis.We delineate the key targets of molecular mediators involved in OS and ferroptosis implicated in depression,most notably reactive oxygen species and iron overload.Considering the pivotal role of OS-induced ferroptosis in the pathogenesis of neurological disorders,delving deeper into the underlying subsequent mechanisms will contribute significantly to the identification of novel therapeutic targets for depression. | Luyao Wang Rongyang Xu Chengying Huang Guozhong Yi Zhiyong Li Huayang Zhang Rongxu Ye Songtao Qi Guanglong Huang Shanqiang Qu | 2023 | General Psychiatry2023，36，5： | 0 |
| 2 | The antiferroptotic role of TRIM7:Molecular mechanism and synergistic effect with temozolomide显示文摘Ferroptosis is a distinct form of regulated cell death characterized by the accumulation of lipid peroxides and iron-dependent membrane damage that is a significant contributor to drug resistance in glioblastoma(GBM).Dysregulated iron metabolism is a hallmark of cancer,making ferroptosis a unique potential target for anticancer therapy.Ferritinophagy,the selective autophagy of ferritin,plays an essential role in cellular iron homeostasis and may impact the vulnerability of cells to ferroptosis.Nuclear receptor coactivator 4(NCOA4)protein is a selective cargo receptor that plays a crucial role in ferritinophagy by targeting and delivering the ferritin iron storage protein to the lysosome for degradation,releasing iron[1].However,the underlying molecular mechanism that causes reduced NCOA4 expression in glioma is not fully understood. | Luyao Wang Rongyang Xu Chengying Huang Shanqiang Qu | 2023 | Cancer Innovation2023，2，4： | 0 |
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