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| 1 | Mechanisms of Helicobacter pylori antibiotic resistance:An updated appraisal显示文摘Helicobacter pylori(H. pylori) antibiotic resistance is the main factor affecting the efficacy of the current eradicating therapies. The aim of this editorial is to report on the recent information about the mechanisms accounting for the resistance to the different antibiotics currently utilized in H. pylori eradicating treatments. Different mechanisms of resistance to clarithromycin,metronidazole,quinolones,amoxicillin and tetracycline are accurately detailed(point mutations,redox intracellular potential,pump efflux systems,membrane permeability) on the basis of the most recent data available from the literature. The next hope for the future is that by improving the knowledge of resistance mechanisms,the elaboration of rational and efficacious associations for the treatment of the infection will be possible. Another auspicious progress might be the possibility of a cheap,feasible and reliable laboratory test to predict the outcome of a therapeutic scheme. | Vincenzo De Francesco Angelo Zullo Cesare Hassan Floriana Giorgio Rosa Rosania Enzo Ierardi | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，3： | 10 |
| 2 | From chronic liver disorders to hepatocellular carcinoma: Molecular and genetic pathways显示文摘Hepatocarcinogenesis is a process attributed to progressive genomic changes that alter the hepatocellular phenotype producing cellular intermediates that evolve into hepatocellular carcinoma (HCC). During the preneoplastic phase, the liver is often the site of chronic hepatitis and/or cirrhosis, and these conditions induce liver regeneration with accelerated hepatocyte cycling in an organ that is otherwise proliferatively at rest. Hepatocyte regeneration is accelerated by upregulation of mitogenic pathways involving molecular and genetic mechanisms. Hepatic growth factors, inhibitors and triggers may also play a role. This process leads to the production of monoclonal populations of aberrant and dysplastic hepatocytes that have telomerase reexpression, microsatellite instability, and occasionally structural aberrations in genes and chromosomes. Development of dysplastic hepatocytes in foci and nodules and the emergence of HCC are associated with the accumulation of irreversible structural alterations in genes and chromosomes even if the genomic basis of the malignant phenotype is largely heterogeneous. Therefore, a malignant hepatocyte phenotype may be produced by changes in genes acting through different regulatory pathways, thus producing several molecular variants of HCC. On these bases, a key point for future research will be to determine whether the deletions are specific, due to particular loci in the minimally deleted regions of affected chromosome arms, or whether they are nonspecific with loss of large portions of chromosomes or entire chromosome arms leading to passive deletion of loci. The final aim is the possibility of identifying a step where carcinogenetic processes could be terminated. | Enzo Ierardi Rosa Rosania Mariangela Zotti Floriana Giorgio Simonetta Prencipe Nicola Della Valle Vincenzo De Francesco Carmine Panella | 2010 | World Journal of Gastrointestinal Oncology2010，2，6： | 2 |
| 3 | Pulmonary administration of a water-soluble curcumin complex reduces severity of acute lung injury显示文摘 | Suresh MV Wagner MC Rosania GR | 2012 | Am J Respir Cell Mol Biol2012，47，3： | 1 |
| 4 | The Use of Human Albumin for the Treatment of Ascites in Patients with Liver Cirrhosis: Item of Safety, Facts, Controversies and Perspectives显示文摘 | Antonio Facciorusso Maurizio Cosimo Nacchiero Rosa Rosania Giulio Laonigro Nunzio Longo Carmine Panella Enzo Ierardi | 2011 | Current Drug Safety2011，，4： | 1 |
| 5 | Probiotic multi- strain treatment may eradicate Helicobacter pylori from the stomach of dyspeptics:A placebo-controlled pilot study显示文摘 | Rosania R Minenna MF Giorgio F | 2012 | Inflamm Allergy Drug Targets2012，11，3： | 1 |
| 6 | Microtubules can modulate pseudopod activity from a distance inside macrophages显示文摘 | Rosania G R Swanson J A | 1996 | Cell Motil Cytoskeleton1996，34，： | 1 |
| 7 | Stress, depression, cortisol, and periodontal disease 显示文摘 | Rosania AE Low KG McCormick CM | 2009 | J Periodontol2009，80，2： | 1 |
| 8 | Microtubules can modulate pseudopod activity from a distance inside macrophages显示文摘 | ROSANIA G R SWANSON J A | 1996 | Cell Motil Cytoskeleton1996，34，： | 1 |
| 9 | Stress,depression,cortisol,and periodontal disease显示文摘 | Rosania AE Low KG McCormick CM | 2009 | J Periodontol2009，80，2： | 1 |
| 10 | Pulmonary Administration of a Water-Soluble Curcumin Complex Reduces Severity of Acute Lung Injury显示文摘 | Suresh Madathilparambil V Wagner Matthew C Rosania Gus R Stringer Kathleen A Min Kyoung Ah Risler Linda Shen Danny D Georges George E Reddy Aravind T Parkkinen Jaakko Reddy Raju C | 2012 | EN2012，，： | 1 |
| 11 | Quantitative modeling of selective lysosomal targeting for drug design 显示文摘 | Trapp S Rosania G R Horobin R W | 2008 | Eur Biophys J2008，37，8： | 1 |
| 12 | Stress, de- pression, eortisol, and periodontal disease 显示文摘 | Rosania AE Low KG McCormick CM | 2009 | J Period- ontol2009，80，2： | 1 |
| 13 | Probiotic multistrain treatment may eradicate Helicobacter pylori from the stomach of dyspeptics: a placebo-controlled pilot study 显示文摘 | Rosania R Minenna MF Giorgio F | 2012 | Inflamm Allergy Drug Targets2012，11，3： | 1 |
| 14 | Probiotic multistrain treatment may eradicate Helicobacter pylori from the stomach of dyspeptics:a placebo-controlled pilot study显示文摘 | Rosania R Minenna MF Giorgio F | 2012 | Inflamm Allergy Drug Targets2012，11，3： | 1 |
| 15 | Combinatorial approach to organelle-targeted fluorescent library based on the styryl scaffold显示文摘 | Rosania G R Lee J W Ding L | 2003 | J Am Chen Soc2003，125，5： | 1 |
| 16 | Stress, depression, cortisol, and periodontal disease显示文摘 | Rosania AE Low KG McCormick CM | 2009 | J Perio-dontol2009，80，2： | 1 |
| 17 | Development of novel cell-permeable DNA sensitive dyes using combinatorial synthesis and cell-based screening显示文摘 | Jung M Rosania G R | 2003 | Chem Commun: (Camb)2003，7，15： | 1 |
| 18 | Mucosal assessment of tumor necrosis factor alpha levels on paraffined samples: a comparison between immunohistochemistry and real time polymerase chain reaction显示文摘 | Enzo Ierardi Floriana Giorgio Rosa Rosania Mariangela Zotti Simonetta Prencipe Nicola Della Valle Vincenzo De Francesco Carmine Panella | 2010 | Scandinavian Journal of Gastroenterology (-)2010，，7： | 1 |
| 19 | Probiotic muhistrain treatment may eradicate Helicobacter pylori from the stomach of dyspeptics: a placebo-controlled pilot study 显示文摘 | Rosania R Minenna MF Giorgio F | 2012 | Inflamm Allergy Drug Targets2012，11，3： | 1 |
| 20 | Probiotic multistraintreatment may eradicate Helicobacter pylori from the stomach ofdyspeptics:a placebo-controlled pilot study显示文摘 | Rosania R Minenna MF Giorgio F | 2012 | Inflamm AllergyDrug Targets2012，11，3： | 1 |
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