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| 1 | Recent trends in the surgical management of inflammatory bowel disease显示文摘Surgery is required in the vast majority of patients with Crohn’s disease (CD) and in approximately one-third of patients with ulcerative colitis (UC). Similar to medical treatments for IBD, significant advances have occurred in surgery. Advances in CD include an emphasis upon conservatism as exemplified by more limited resections, strictureplasties, and laparoscopic resections. The use of probiotics in selected patients has improved the outcome in patients with pouchitis following restorative proctocolectomy for UC. It is anticipated that ongoing discoveries in the molecular basis of IBD will in turn identify those patients who will best respond to surgery. | Robert E Roses John L Rombeau | 2008 | World Journal of Gastroenterology2008，14，3： | 10 |
| 2 | Multidisciplinary management of nonfunctional neuroendocrine tumor of the pancreas显示文摘Pancreatic neuroendocrine tumors(PNETs) are a rare and diverse group of tumors; nonfunctional(NF) PNETs account for the majority of cases. Most patients with NF-PNETs have metastatic disease at the time of presentation. A variety of treatment modalities exist, including medical, liver directed, and surgical treatments. Aggressive surgical management is associated with prolonged survival, however available data are limited by selection bias and the frequent combination of PNETs with carcinoid tumors. Although few patients with metastatic disease will be cured, application of currently available therapies in a multidisciplinary setting can lead to excellent outcomes with prolonged patient survival. | Ian W Folkert Paul Hernandez Robert E Roses | 2016 | World Journal of Gastroenterology2016，22，11： | 6 |
| 3 | Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy显示文摘AIM:To investigate whether tumor marker staining can improve the sensitivity of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)to diagnose pancreatic malignancy. METHODS:Patients who underwent EUS-FNA were retrospectively identified.Each EUS-FNA specimen was evaluated by routine cytology and stained for tumor markers p53,Ki-67,carcinoembryonic antigen(CEA) and CA19-9.Sensitivity,specificity,positive and negative predictive values(PPV and NPV),and positive and negative likelihood ratios(PLR and NLR)were calculated in order to evaluate the performance of each test to detect malignancy. RESULTS:Sixty-one specimens had complete sets of stains,yielding 49 and 12 specimens from pancreatic adenocarcinomas and benign pancreatic lesions due to pancreatitis,respectively.Cytology alone had sensitivity and specificity of 41%and 100%to detect malignancy, respectively.In 46%of the specimens,routine cytology alone was deemed indeterminate.The addition of either p53 or Ki-67 increased the sensitivity to 51%and 53%,respectively,with perfect specificity,PPV and PLR (100%,100%and infinite).Both stains in combination increased the sensitivity to 57%.While additional staining with CEA and CA19-9 further increased the sensitivity to 86%,the specificity,PPV and PLR were significantly reduced(at minimum 42%,84%and 1,respectively).Markers in all combinations performed poorly as a negative test(NPV 26%to 47%,and NLR 0.27 and 0.70).CONCLUSION:Immunohistochemical staining for p53 and Ki-67 can improve the sensitivity of EUS-FNA to diagnose pancreatic adenocarcinoma. | Alexander W Jahng Sonya Reicher David Chung Donna Varela Rahul Chhablani Anil Dev Binh Pham Jose Nieto Rose J Venegas Samuel W French Bruce E Stabile Viktor E Eysselein | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 3 |
| 4 | An ORF2 protein-based ELISA for porcine circovirus type 2 antibodies in post-weaning multisystemic wasting syndrome显示文摘 | Ph Blanchard D Mahé R Cariolet C Truong M Le Dimna C Arnauld N Rose E Eveno E Albina F Madec A Jestin | 2003 | Veterinary Microbiology2003，，3： | 2 |
| 5 | Do statins reduce hepatitis C RNA titers during routine clinical use?显示文摘AIM: To compare hepatitis C virus (HCV) titers in patients with chronic hepatitis C with and without exposure to 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins).METHODS: Medical records were reviewed for 6463 patients with documented HCV infection at a single center between March 2004 and September 2006. Patients with confi rmed viremia and meeting inclusion criteria were assigned to one of three groups: Group A (n = 50), dyslipidemic patients with statin usage during HCV RNA polymerase chain reaction (PCR) determination; Group B (n = 49), dyslipidemic patients with prior or future statin usage but not at the time of HCV RNA PCR determination; and Group C (n = 102), patients without statin usage during the study period. The primary analysis explored the effect of statin therapy on HCV viremia. Secondary analyses assessed class effect, dose response, and effect of other lipid-lowering therapies on HCV viral titers.RESULTS: Median HCV RNA titers did not signif icantly differ among the three groups (Group A: 4 550 000 IU/mL, Group B: 2 850 000 IU/mL, Group C: 3 055 000 IU/mL).For those subjects with longitudinal assessment of HCV viremia prior to and while on statins, there were no signif icant differences between pre- and post-HCV viral titers. Additionally, no differences in HCV titers were observed at any dose level of the most prescribed statin, simvastatin. However, hypertriglyceridemia independently correlated with HCV titers, and niacin exposure was associated with signif icantly lower viral titers (P < 0.05).CONCLUSION: There was no apparent effect of statins on HCV viral replication in this analysis. Further investigation is warranted to explore the possible antiviral properties of triglyceride-lowering agents and their potential role as adjuncts to standard HCV therapy. | Kimberly A Forde Connie Law Rose O’Flynn David E Kaplan | 2009 | World Journal of Gastroenterology2009，15，40： | 2 |
| 6 | Caesium-137 profiles in the sediments of a partial-meromictic lake on Great Sandy Island (Fraser Island),Queensland,Australia显示文摘 | LONGMORE M E O'LEARY B M ROSE C W | 1983 | Hydrobiologia1983，103，： | 1 |
| 7 | Anterior cruciate ligamenl radiofrequency thermal shrinkage:As hort-term follow-up显示文摘 | Famg E Hunt S A Rose D J | 2005 | Arthroscopy2005，21，9： | 1 |
| 8 | Individual differences in nicotine dependence,withdrawal symptoms,and sex predict transient fMRI-BOLD responses to smoking cues显示文摘 | McClernon F J Kozink R V Rose J E | 2008 | Neuropsychopharmacology2008，33，9： | 1 |
| 9 | POEMS syndrome显示文摘 | Rose C Mahieu M Haehuiia E | 1997 | Rev Mod inteme1997，18，： | 1 |
| 10 | Verbs and Adverbs:Multidimensional Motion Interpolation 显示文摘 | Rose C E Cohen M Bodenheimer B | 1998 | IEEE Computer Graphics & Application (S0272-1716)1998，18，5： | 1 |
| 11 | Replication and amplification of novel vesicular stomatitis virus minigenomes encoding viral structural proteins 显示文摘 | Stillman E A Rose J K Whitt M A | 1995 | J Virol1995，69，： | 1 |
| 12 | Long-term moni- toring shows hepatitis B virus resistance to entecavir in nude- oside-na ve patients is rare through 5 years of therapy显示文摘 | Tenney D J Rose R E Baldick C J | 2009 | Hepatology2009，49，5： | 1 |
| 13 | Cryptosporidium parvum and Cyclospora cayetanensis : A review of laboratory methods for detection of these waterborne parasites 显示文摘 | QUINTERO-BETANCOURT W PEELE E R ROSE J B | 2002 | Journal of Microbiological Methods2002，49，3： | 1 |
| 14 | Biochemical mechanisms and diagnostic microassays for pyrethroid, carbamate, and organophosphate insecticide resistance/ cross-resistance in the tobacco budworm, Heliothis virescens 显示文摘 | Zhao G Y Rose R L Hodgson E | 1996 | Pesticide Biochemistry and Physiology1996，56，3： | 1 |
| 15 | The association between DRD2/ANKK1 and genetically informed measures of alcohol use and problems显示文摘 | Meyers JL Nyman E Loukola A Rose RJ Kaprio J Dick DM | | 0，，03： | 1 |
| 16 | Using GPS data to gain insight into public transport travel time variability显示文摘 | Mazloumi E Currie G Rose G | | 0，，07： | 1 |
| 17 | Sensorineural hearing loss from quinolinic acid:a neurotoxin in middle ear effusions显示文摘 | Yellon R F Rose E Kenna M A | 1994 | Laryngoscope1994，104，2： | 1 |
| 18 | PAM effect on infiltration in irrigated agriculture 显示文摘 | Sojka R E Lentz R D Rose C W | 1998 | Soil Water Conserv1998，，53： | 1 |
| 19 | Pediatric dacryocystorhinostomy for nasolacrimal duct obstruction显示文摘 | BARNES E A ABOU-RAYYAH Y ROSE G E | 2001 | Ophthalmology2001，108，9： | 1 |
| 20 | Consensusdegenerate hybrid oligonucleotide primers for amplification of distantly related sequences显示文摘 | Rose T M Schultz E R Henikoff J G | 1998 | Nucleic Acids Res1998，26，7： | 1 |
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