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| 1 | 通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病显示文摘 AIM:To evaluate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.METHODS:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liver biopsies,the first at surgery and the second after 16 ± 3 mo of weight loss.Biopsies were evaluated and compared in a blinded fashion.The presence of metabolic syndrome,anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy.RESULTS:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prevalence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P < 0.001).Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery.There were improvements in steatosis(P < 0.001),lobular(P < 0.001) and portal(P < 0.05) inflammation and fibrosis(P < 0.001) at the second biopsy.There were 25(96.1%) patients with non alcoholic steatohepatitis(NASH) in their index biopsy and only four(15.3%) of the repeat biopsies fulfilled the criteria for NASH.The persistence of fibrosis(F > 1) was present in five patients at second biopsy.Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery.CONCLUSION:Restrictive mildly malabsorptive surgery provides significant weight loss,resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients. | Víctor Vargas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 2 | Angiogenesis vascular endothelial growth factor and platelet-derived growth factor BB expression,iron deposition,and oxidation-specific epitopes in stented human coronary arteries显示文摘 | Brasen JH Kivela A Roser K | 2001 | Arterioscler Thromb Vasc Biol2001，21，11： | 1 |
| 3 | The renaissance and bright future of fiber lasers显示文摘 | Tunnermann A Schreiber T Roser F | 2005 | J Phys B At Mol Opt Phys2005，38，： | 1 |
| 4 | Transition from meningeal melanocytoma to primary cerebral melanoma 显示文摘 | Roser F Nakamura M Brandis A | 2004 | Case report d Neurosurg2004，，： | 1 |
| 5 | The use of polymerase chain reaction(PCR) for the detection of bean yellow mosaic virus in gladiolus显示文摘 | Vnnsh R Roser A Stein A | 1990 | Annals of Applied Biology1990，117，： | 1 |
| 6 | The use of polymerase chain reaction(PCR)for the detection of bean yellow mosaic virus in gladiolus显示文摘 | VNNSH R ROSER A STEIN A | 1990 | Annals of Applied Biology1990，117，13： | 1 |
| 7 | Tendoscopy of the Achilles tendon: indications, technique and results 显示文摘 | Kriegelstein S Altenberger S Roser A | 2016 | Unfall Chirurg2016，119，2： | 1 |
| 8 | Phylogeny of all recognized species of ammonia oxidizers based on comparative 16S rRNA and amoA sequence analysis: implications for molecular diversity surveys 显示文摘 | Purkhold U Roser A Juretschko S | 2000 | Applied and Environmental Microbiology2000，66，12： | 1 |
| 9 | The T191M mutation of the CBS gene is highly prevalent among homoeystinuric patients from Spain, Portugal and South America显示文摘 | Roser U Carta A Marta B | 2006 | J Hum Genet2006，51，： | 1 |
| 10 | Recurrence and increased Proliferation Rate of a Solitary Fibrous Tumor in The Central Nervous System -Case Report and Review of the Literature 显示文摘 | Ritz R Roser F Bornemann A | 2005 | Clin Neuropathol2005，24，4： | 1 |
| 11 | Productivity and cost of mechanized energy wood harvesting in Northern Scotland 显示文摘 | ROSER D SIKANEN L ASIKAINEN A | 2011 | BiomassandBioenergy2011，35，11： | 1 |
| 12 | Managing your co-creation mix: Co-creation ventures in distinctive contexts显示文摘 | Roser T DeFillippi R Samson A | 2013 | European Business Review2013，25，1： | 1 |
| 13 | Phylogeny of all recognized species of ammonia oxidizers based on comparative 16S rRNA and amoA sequence analysis: implications for molecular diversity surveys 显示文摘 | PURKHOLD U ROSER A JURETSCHKO S | 2000 | Appl Environ Microbiol2000，66，12： | 1 |
| 14 | Extraventricular Neurocytoma Presenting with Intratumoral Hemorrhage显示文摘 | Ritz R Roser F Bornemann A | 2005 | Clin Neuropathology2005，24，3： | 1 |
| 15 | Primary non-Hodgkin lym- phoma of the cranial nerves mimicking neurofibromatosis Type 2- case illustration显示文摘 | Koerbel A Roser F Psaras T | 2005 | J Neurosurg2005，102，6： | 1 |
| 16 | Augiogenesis, vascular endothelial growth factor and ptatelet-derived growth factor-BB expression,iron depo- sition and oxidation-specific epitopes in stented human coronary arteries 显示文摘 | Brasen JH Kivela A Roser K | 2001 | Aterioscler Thromb Vasc Biol2001，21，11： | 1 |
| 17 | Effects of vitrification in open pulled straws on the cytology of invitro matured prepubertal and adult bovine oocytes 显示文摘 | JoseL A Roser M Claudia R | 2005 | Theriogenology2005，63，： | 1 |
| 18 | Extraventricular neurocyto- ma presenting with intratumoral hemorrhage 显示文摘 | Ritz R Roser F Bornemann A | 2005 | Clin Neuro- pathol2005，24，3： | 1 |
| 19 | Angiogenesis,vascular en- dothelial growth factor and platelet-derived growth factor--BB expression, iron deposition,and oxidation-specific epitopes in stent- ed human coronary arteries 显示文摘 | Brmsen JH Kivela A Roser K | 2001 | Arterioscler Thromb Vasc Biol2001，21，11： | 1 |
| 20 | Functional relevance of the BMD- associated polymorphism rs312009: Novel involvement of RUNX2 in LRP5 transcriptional regulation 显示文摘 | Lidia A Rafael VC Roser U | 2011 | J Bone Miner Res2011，26，5： | 1 |
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