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| 1 | New Evidence on the Expectations Theory of the Term Structure of Australian Commonwealth Government Treasury Yields显示文摘 | Guest Ross McLean Alan | 1998 | Applied Financial Economics1998，8，1： | 1 |
| 2 | Efficacy of feedback training in long-standing facial nerve paresis显示文摘 | Ross B Nedzelski JM McLean JA | 1991 | Laryngoscope1991，101，： | 1 |
| 3 | Anxiety disorders during pregnancy and the postpartum period:a systematic review显示文摘 | Ross LE McLean LM | 2006 | J Clin Psychiatry2006，67，8： | 1 |
| 4 | Increased CD4/CD8 Lymphocyte ratio predicts favourable neoadjuvant treatment response in gastric cancer:A prospective pilot study显示文摘BACKGROUND Despite optimal neoadjuvant chemotherapy only 40%of gastric cancer tumours achieve complete or partial treatment response.In the absence of treatment response,neoadjuvant chemotherapy in gastric cancer contributes to adverse events without additional survival benefit compared to adjuvant treatment or surgery alone.Additional strategies and methods are required to optimize the allocation of existing treatment regimens such as FLOT chemotherapy(5-Fluorouracil,Leucovorin,Oxaliplatin and Docetaxel).Predictive biomarkers detected using immunohistochemistry(IHC)methods may provide useful data regarding treatment response.AIM To investigate the utility of CD4,CD8,Galectin-3 and E-cadherin in predicting neoadjuvant FLOT chemotherapy tumour response in gastric adenocarcinoma.METHODS Forty-three adult patients with gastric adenocarcinoma,of which 18 underwent neoadjuvant chemotherapy,were included in a prospective clinical cohort.Endoscopic biopsies were obtained from gastric cancer and normal adjacent gastric mucosa.Differences in expression of Galectin-3,Ecadherin,CD4^(+)and CD8^(+)molecules between tumours with and without treatment response to neoadjuvant chemotherapy were assessed with IHC.Treatment response was graded by clinical pathologists using the Tumour Regression Score according to the College of American Pathologists criteria.Treatment response was defined as complete or near complete tumour response,whereas partial or poor/no response was defined as incomplete.Digital IHC images were annotated and quantitatively assessed using QuPath 0.3.1.Biomarker expression between responsive and incomplete response tumours was assessed using a two-sided Wilcoxon test.Biomarker expression was also compared between normal and cancer tissue and between 15 paired tumour samples before and after chemotherapy.We performed a preliminary multivariate analysis and power analysis to guide future study.Statistical analyses were completed using R 4.1.2.RESULTS The ratio between CD4^(+)and CD8^(+)lymphocytes was significantly greater in treatment responsive tumours(Wilcoxon,P=0.03).In univariate models,CD4^(+)/CD8^(+)ratio was the only biomarker that significantly predicted favourable treatment response(Accuracy 86%,P<0.001).Using a glmnet multivariate model,high CD4^(+)/CD8^(+)ratio and low Galectin-3 expression were the most influential variables in predicting a favourable treatment response.Analyses of paired samples found that FLOT chemotherapy also results in increased expression of CD4^(+)and CD8^(+)tumour infiltrating lymphocytes(Paired Wilcoxon,P=0.002 and P=0.008,respectively).Our power analysis suggests future study requires at least 35 patients in each treatment response group for CD8 and Galectin-3 molecules,whereas 80 patients in each treatment response group are required to assess CD4 and E-cadherin biomarkers.CONCLUSION We demonstrate that an elevated CD4^(+)/CD8^(+)Ratio is a promising IHC-based biomarker to predict favourable treatment response to FLOT neoadjuvant chemotherapy in locally advanced gastric cancer. | Daniel Skubleny Andrea Lin Saurabh Garg Ross McLean Michael McCall Sunita Ghosh Jennifer L Spratlin Daniel Schiller Gina Rayat | 2023 | World Journal of Gastrointestinal Oncology2023，15，2： | 1 |
| 5 | Efficacy of feedback training in long - standing facial nerveparesis 显示文摘 | Ross B Nedzelski J M Mclean J A | 1991 | Laryngo- scope1991，101，： | 1 |
| 6 | Efficacy of feedback training in long-standing facial nerve paresis显示文摘 | Ross B Nedzelski JM McLean JA | 1991 | Laryn- goscope1991，101，7： | 1 |
| 7 | The effect of towing a range of relative resistances on sprint performance显示文摘 | A. Murray TC Aitchison G. Ross K. Sutherland I. Watt D. McLean S. Grant | 2005 | Journal of Sports Sciences2005，，： | 1 |
| 8 | Bioacoustic distances between the begging calls of brood parasites and their host species:a comparison of metrics and techniques显示文摘 | Ranjard L Anderson MG Rayner MJ Payne RB McLean I Briskie JV Ross HA Brunton DH Woolley SMN Hauber ME | | 0，，： | 1 |
| 9 | Ectopic adrenal tissue in adults 显示文摘 | Anderson JR McLean Ross AH | 1980 | Postgrad Med J1980，56，6： | 1 |
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