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| 1 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 2 | Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2显示文摘 | Rost S Fregin A Ivaskevicius V | 2004 | Nature2004，427，6974： | 1 |
| 3 | Anemia and hematoma volume in acute intracerebral hemorrhag显示文摘 | Kumar M A Rost N S Snider R W | 2009 | Crit Care Med2009，37，5： | 1 |
| 4 | Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor defi- ciency type 2显示文摘 | Rost S Fregin A Ivaskevicius V | 2004 | Nature2004，427，6974： | 1 |
| 5 | Ultrafast endocyto- sis at mouse hippocampal synapses 显示文摘 | Watanabe S Rost BR Camacho-Perez M | 2013 | Nature2013，504，： | 1 |
| 6 | Anatolnic suitability of the C1-C2 complex for pedicle screw fixation显示文摘 | Resnick DK Lapsiwala S Rost GR | | 0，，14： | 1 |
| 7 | Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2显示文摘 | Rost S Fregin A Ivaskevicius V | 2004 | Nature2004，427，6974： | 1 |
| 8 | Carbon acquisition of bloom-forming marine phytoplankton 显示文摘 | Rost B Riebesell U Burrkhardt S | 2003 | Limnology and Ocea-nography2003，48，： | 1 |
| 9 | Mutations in VKORC 1 cause warfarin resistance and multiple coagulation factor deficiency type 2 显示文摘 | Rost S Fregin A Ivaskevicius V | 2004 | Nature2004，427，6974： | 1 |
| 10 | Advances of a spatial sine testing system显示文摘 | Severyn A J Barney P S Rost W Brown D L | 1989 | International Modal Analysis Conference Las Vegas Nevada1989，，： | 1 |
| 11 | Determinats of white matter hyperintensity volume in patients with acute ischemic stroke显示文摘 | Rost NS Rahman R Sonni S | 2010 | J Stroke Cerebrovasc Dis2010，19，3： | 1 |
| 12 | Novel form of X-linked nonsyndromic hearing loss with cochlear malformation caused by a mutation in the type IV collagen gene COL4A6显示文摘 | Rost S Bach E Neuner C | 2014 | Europ J Hum Genet2014，22，： | 1 |
| 13 | Learner use of strategies in interaction: Typology and Teachability 显示文摘 | Rost M Ross S | 1991 | Language Learning1991，41，： | 1 |
| 14 | Do rankings Reflect Research Quality? 显示文摘 | Frey B S Rost K | 2010 | Journal of Applied Economics2010，13，1： | 1 |
| 15 | Mutations in VKORCI cause wafarin resistance and multiple coagulation factor deficiency type2显示文摘 | Rost S Fregin A Ivaskevicius V | 2004 | Nature2004，427，6974： | 1 |
| 16 | Spatially distributed p-n heterojunction based on nanoporous TiO2 and CuSCN 显示文摘 | Rost C Sieber I Siebentritt S | 1999 | Appl Phys Lett1999，75，5： | 1 |
| 17 | Determinants of white matter hyperintensity volume in patients with acute ischemie stroke 显示文摘 | Rost NS Rahman R Sonni S | 2010 | J Stroke Cerebrovasc Dis2010，19，3： | 1 |
| 18 | mRNA levels of membrane-type 1 matrix metalloproteinases (MT1-MMP),MMP-2, and MMP-9 and of their inhibitors TIMP-2 and TIMP3 in normal thyrocytes and thyroid carcinoma cell lines 显示文摘 | Hofmann A Laue S Rost AK | 1998 | Thyroid1998，8，3： | 1 |
| 19 | Silent ische- mic infarcts are associated with hemorrhage burden in cer- ebral amyloid angiopathy 显示文摘 | Kimberly W T Gilson A Rost N S | 2009 | Neurology2009，72，14： | 1 |
| 20 | mRNA levels of memberane-type 1 matrix metallo-proteinases (MT1-MMP), MMP-2, and MMP-9 and or their inhibitors TIMP-2 and TIMP-3 in normal thyrocytes and thyroid carcinoma cell lines显示文摘 | Laue S Rost AK | 1998 | Thyroid1998，8，3： | 1 |
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