|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | Randomized, Placebo-Controlled, Clinical Trial of Donepezil in Vascular Dementia: Differential Effects by Hippocampal Size显示文摘 | Gustavo C. Román Stephen Salloway Sandra E. Black Donald R. Royall Charles DeCarli Michael W. Weiner Margaret Moline Dinesh Kumar Rachel Schindler Holly Posner | 2010 | Stroke2010，，6： | 2 |
| 3 | Activation of cdc42,rac,PAK,and rho kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation显示文摘 | Royal I Lamarche-Vane N Lamorte L | 2000 | Mol Biol Cell2000，11，5： | 1 |
| 4 | Droplet-based sensing: Optical microresonator sensors embedded in digital electrowetting microfluidics systems显示文摘 | Royal M W Jokerst N M and Fair R B | 2013 | IEEE Sensors Journal2013，13，12： | 1 |
| 5 | Nitric oxide-related oxidants in acute lung injury显示文摘 | ROYALL J A KOOY N W BEEKMAN J S | 1995 | New Horiz1995，3，1： | 1 |
| 6 | Activation of Cdc42, Rac, PAK, and Rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation显示文摘 | Royal I Lamarche Vane N Larmorte L | | 0，，： | 1 |
| 7 | Transcriptional activation of the neuronal peripherin-encoding gene depends on a G+C-rich element that binds Sp1 in vitro and in vivo显示文摘 | Desmarais D Royal A | 1995 | Gene1995，159，2： | 1 |
| 8 | Nitric oxide related oxidants in acute lung injury显示文摘 | Royall J A Kooy N W Beckman J S | 1995 | New Heriz1995，3，： | 1 |
| 9 | Evidence for in vivo peroxy nitric production in human acute lung injury显示文摘 | Kooy N W Royall J A Ye Y Z | 1995 | Am J Respir CritCare Med1995，151，： | 1 |
| 10 | Evidence for in vivo peroxynitrite production in human acute lung injury显示文摘 | KOOY N W ROYALL J A YE Y Z | 1995 | Am J Respir Crit Care Med1995，151，： | 1 |
| 11 | Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation 显示文摘 | Royal I Lamarche-Vane N Lamorte L | 2000 | Mol Biol Cell2000，11，5： | 1 |
| 12 | Shock-induced chemical reactions in titanium-silicon powder mixtures of different morphologies: Time-resolved pressure measurements and materials analysis 显示文摘 | Thadhani N N Graham R A Royal T | 1997 | J Appl Phys1997，82，3： | 1 |
| 13 | Peroxynitrite-mediated oxidation of dihydrorhodamine 123显示文摘 | Kooy N W Royall J A Ischiropoulos H | | 0，，02： | 1 |
| 14 | Activation of cdc42, rac, PAK, and rho kinase in response to hepatoeyte growth factor differentially regulates epithelial cell colony spreading and dissociation 显示文摘 | Royal I Lamarche-Vane N Lamorte L | 2000 | Mol Biol Cell2000，11，： | 1 |
| 15 | Activation of cdc42, rac, PAK, and rho-kinase in response to hepa- tocyte growth factor differentially regulates epithelial cell colony spreading and dissociation 显示文摘 | Royal I Lamarche-Vane N Lamorte L | 2000 | Mol Biol Cell2000，11，5： | 1 |
| 16 | Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation 显示文摘 | Royal I Lamarche-Vane N Lamorte L | 2000 | Mol Biol Ce112000，11，5： | 1 |
| 17 | Shockinduced chemical reactions in titanium-silicon powder mixtures of different morphologies:Time-resolved pressure measurements and materials analysis显示文摘 | Thadhani N N Graham R A Royal T | | 0，，03： | 1 |
| 18 | Murine norovirus 1 (MNV1) replication induces translational control of the host by regulating eIF4E activity during infection 显示文摘 | Royall E Doyle N Abdul-Wahab A | 2015 | J Biol Chem2015，290，8： | 1 |
| 19 | Progxynitrite-mediated oxidation of dihydrorhodamine 123 显示文摘 | N W Kooy J A Royall H Ischiropoulos | 1994 | Free Radic Biol Med1994，16，2： | 1 |
| 20 | Evidence for in vivo peroxynitrite production in human acute lung injury显示文摘 | Kooy N M Royall J A | 1995 | Am J Reapir Grit Med1995，151，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员