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| 1 | ^99Tc^m-MIBI心肌灌注显像及^18F-FDG PET心肌代谢显像探测左心室室壁瘤心肌存活性的临床价值显示文摘目的评估^99锝^18-甲氧基异腈(^99Tc^m-MIBI)单光子发射计算机断层(SPECT)心肌灌注显像及^18F-脱氧葡萄糖(FDG)正电子发射断层(PET)心肌代谢显像探测左心室室壁瘤(室壁瘤)心肌存活性的临床价值。方法46例确诊为室壁瘤合并左心功能不全[左心射血分数(LVEF)36%±7%],行^99Tc^m-MIBI SPECT+^18 F-FDGPET显像,并接受血运重建术的患者,随访(80±27)个月。根据室壁瘤是否有存活心肌[灌注一代谢不匹配分(MMS)≥2.0分]以及是否行室壁瘤切除术,将患者分为4个小组:室壁瘤无存活心肌(A组):血运重建术为A1组(n=8),血运重建术+瘤切除术为A2组(n=15);室壁瘤有存活心肌(B组):血运重建术为B1组(n=10),血运重建术+瘤切除术为B2组(n=13)。结果A1、A2、B1、B24个组心脏事件发生率分别为25%(2/8),40%(6/15),20%(2/10)和31%(4/13)(P〉0.05)。除A1组外,其他各组的术后左心功能均得到明显改善(P〈0.05)。多因素logistic回归分析筛选出与术后LVEF改善相关的独立影响因素,为左心室的MMS(OR=2.34,95%CI1.08—5.06,P〈0.05),非室壁瘤部位的心肌灌注分(OR=0.24,95%CI 0.07~0.85,P〈0.05)和远端血管病变(OR=0.008,95%CI 0.001~0.560,P〈0.05)。结论室壁瘤接受血运重建术的患者,长期预后良好。室壁瘤部位有存活心肌的患者,单纯的血运重建术也可以明显改善左心功能,且与心肌存活的量相关。 | 张晓丽 刘秀杰 胡盛寿 Thomas Schindler 田月琴 高润霖 吴清玉 魏红星 杨秀滨 王浩 何作祥 Heinrich R.Schelbert | 2008 | 中华心血管病杂志2008，36，11： | 5 |
| 2 | 消融的冰川:加拿大班夫国家公园亚高山带鲍湖中持久性有机氯的主要来源显示文摘有机氯杀虫剂和多氯联苯(PCB)是环境中普遍而稳固的化合物。现已查明,由于它们从温暖的地区逐渐蒸发出来,并在较冷的地区凝聚下来,因而它们富集在寒冷的环境中。在本研究中,我们的结果是,消融的冰川供给阿尔伯达亚高山带湖泊中的有机氯输入量为50%~97%,而提供的水量为73%。对氚的分析结果表明,在夏季的中、晚期,至少10%的冰川消融物是在1950~1970年期间沉积下来的,这期间它受到有机氯更多的污染。这一发现表明,气候变暖可能会使消融的冰川成为日益增多的淡水污染物来源。由于有机物贫乏的冰川粘土对多氯联苯这样的疏水化合物的吸附能力有限,因此冰川水流带来的有机氯大多呈溶解状态。 | Jules M. Blais David W. Schindler Derek C. G. Muir Martin Sharp David Donald MelissaLafrenière Eric Braekevelt William M. J. Strachan 周立志 | 2001 | AMBIO-人类环境杂志2001，30，7： | 4 |
| 3 | Femtojoule electro-optic modulation using a silicon– organic hybrid device显示文摘Energy-efficient electro-optic modulators are at the heart of short-reach optical interconnects,and silicon photonics is considered the leading technology for realizing such devices.However,the performance of all-silicon devices is limited by intrinsic material properties.In particular,the absence of linear electro-optic effects in silicon renders the integration of energy-efficient photonic–electronic interfaces challenging.Silicon–organic hybrid(SOH)integration can overcome these limitations by combining nanophotonic silicon waveguides with organic cladding materials,thereby offering the prospect of designing optical properties by molecular engineering.In this paper,we demonstrate an SOH Mach–Zehnder modulator with unprecedented efficiency:the 1-mm-long device consumes only 0.7 fJ bit^(-1) to generate a 12.5 Gbit s^(-1) data stream with a bit-error ratio below the threshold for hard-decision forward-error correction.This power consumption represents the lowest value demonstrated for a non-resonant Mach–Zehnder modulator in any material system.It is enabled by a novel class of organic electro-optic materials that are designed for high chromophore density and enhanced molecular orientation.The device features an electro-optic coefficient of r33<180 pm V^(-1) and can be operated at data rates of up to 40 Gbit s^(-1). | Sebastian Koeber Robert Palmer Matthias Lauermann Wolfgang Heni Delwin L Elder Dietmar Korn Markus Woessner Luca Alloatti Swen Koenig Philipp C Schindler Hui Yu Wim Bogaerts Larry R Dalton Wolfgang Freude Juerg Leuthold Christian Koos | 2015 | Light(Science & Applications)2015，4，1： | 4 |
| 4 | 从酸雨到毒雪 1998年度Volvo环境奖获奖演说显示文摘本文评论了酸雨和其他空气中毒素研究中出现的一些问题。长期的酸雨消耗了许多地方土壤中的盐基阳离子,并使湖泊不能完全从中恢复。气候变暖和干旱所引起流域中硝酸沉降增加和硫的复氧化同样阻碍了湖泊的恢复。气候变暖、干旱和湖泊酸化也导致湖泊中有色有机物浓度的下降,结果其对常见太阳辐射的衰减下降,使得水生群落在UV中的暴露程度大大增加。包括气候变暖、UV辐射加大、挥发性受温度的控制以及污染物在寒冷地区凝结等在内的诸多因素均有利于有机氯污染物和汞从温暖地区向高海拔和高纬度地区迁移。在高海拔区域,污染物通过食物链生物放大,对当地居民构成了巨大的威胁。 | David Schindler 冯化涛 暴维英 | 1999 | AMBIO-人类环境杂志1999，28，4： | 3 |
| 5 | Progestogens and early pregnancy: prevention and treatment显示文摘During human and mammalian pregnancy,endogenous progesterone is the dominant hormone since it is not only essential for conception and implantation,but also needed throughout pregnancy.Progesterone provided the effects of prevention and treatment in human pregnancy by certain mechanisms.If one considers prevention or treatment with progestogens in human pregnancy,that all progestogens are progestogenic,if one condsiders the progestogens for prevention and therapeutic approaches,nowadays,only two progenstogens can be considered fully suitable for prevention and treatment in human pregnancy:progesterone and dydrogesteone.This review introduced the mechanism of progesterone and dydrogesterone in pregnancy and treatment in human. | Adolf E. Schindler | 2013 | 首都医科大学学报2013，34，4： | 3 |
| 6 | Signaling through the JAK/STAT pathway, recent advances and future challenges显示文摘 | T Kisseleva S Bhattacharya J Braunstein C.W Schindler | 2002 | Gene2002，，1： | 2 |
| 7 | Aroma development in high pressure treated beef and chicken meat compared to raw and heat treated显示文摘 | Sabrina Schindler Ulrich Krings Ralf G. Berger Vibeke Orlien | 2010 | Meat Science2010，，2： | 2 |
| 8 | Biophotonic sensors with integrated Si_(3)N_(4)-organic hybrid (SiNOH) lasers for point-of-care diagnostics显示文摘Early and efficient disease diagnosis with low-cost point-of-care devices is gaining importance for personalized medicine and public health protection.Within this context,waveguide-(WG)-based optical biosensors on the siliconnitride(Si_(3)N_(4))platform represent a particularly promising option,offering highly sensitive detection of indicative biomarkers in multiplexed sensor arrays operated by light in the visible-wavelength range.However,while passive Si_(3)N_(4)-based photonic circuits lend themselves to highly scalable mass production,the integration of low-cost light sources remains a challenge.In this paper,we demonstrate optical biosensors that combine Si_(3)N_(4)sensor circuits with hybrid on-chip organic lasers.These Si_(3)N_(4)-organic hybrid(SiNOH)lasers rely on a dye-doped cladding material that are deposited on top of a passive WG and that are optically pumped by an external light source.Fabrication of the devices is simple:The underlying Si_(3)N_(4)WGs are structured in a single lithography step,and the organic gain medium is subsequently applied by dispensing,spin-coating,or ink-jet printing processes.A highly parallel read-out of the optical sensor signals is accomplished with a simple camera.In our proof-of-concept experiment,we demonstrate the viability of the approach by detecting different concentrations of fibrinogen in phosphate-buffered saline solutions with a sensor-length(L-)-related sensitivity of S/L=0.16 rad nM^(-1)mm^(-1).To our knowledge,this is the first demonstration of an integrated optical circuit driven by a co-integrated low-cost organic light source.We expect that the versatility of the device concept,the simple operation principle,and the compatibility with cost-efficient mass production will make the concept a highly attractive option for applications in biophotonics and point-of-care diagnostics. | Daria Kohler Gregor Schindler Lothar Hahn Johannes Milvich Andreas Hofmann Kerstin Lange Wolfgang Freude Christian Koos | 2021 | Light(Science & Applications)2021，10，4： | 2 |
| 9 | 激素避孕药在合并各种医学疾患妇女中的非避孕用途显示文摘本文是我刊的国外通讯编委、Duisberg-埃森大学妇产科教授、德国埃森医学研究所主任Schindler教授的特约供稿,我们在此翻译刊出以飨读者。 | Adolf E Schindler 赵峻 田秦杰 | 2009 | 生殖医学杂志2009，18，4： | 2 |
| 10 | Randomized, Placebo-Controlled, Clinical Trial of Donepezil in Vascular Dementia: Differential Effects by Hippocampal Size显示文摘 | Gustavo C. Román Stephen Salloway Sandra E. Black Donald R. Royall Charles DeCarli Michael W. Weiner Margaret Moline Dinesh Kumar Rachel Schindler Holly Posner | 2010 | Stroke2010，，6： | 2 |
| 11 | Turning of aluminum metal matrix composites: influence of the reinforcement and the cutting condition on the surface layer of the workpiece显示文摘 | Jan C. Aurich Marco Zimmermann Stefan Schindler Paul Steinmann | 2016 | Advances in Manufacturing2016，4，3： | 2 |
| 12 | Activation of Bel-2-associated death protein and counter-response of Akt within cell populations during seizure-induced neuronal death 显示文摘 | Henshall D C Araki T Schindler C K | 2002 | J Neurosci2002，22，19： | 1 |
| 13 | Porcine pulmonary atery and bronchial responses to endothelin-1 and norepinephrine on recovery from hypoxic pulmonary hypertension显示文摘 | Schindler MB Hislop AA Haworth SG | 2006 | Pediatr Res2006，60，1： | 1 |
| 14 | Effect and safety of high-dose dienogest (20 mg/day) in the treatment of women with endometriosis显示文摘 | SCHINDLER AE HENKEL A MOORE C | 2010 | Arch Gynecol Obstet2010，282，5： | 1 |
| 15 | Structure and distribution of lignin in primary and secondary cell walls of maize coleoptiles analyzed by chemical and immunological probes 显示文摘 | MUSEL G SCHINDLER T BERGFELD R | 1997 | Planta1997，201，： | 1 |
| 16 | The production of IFN-gamma by IL-12/IL-18 activated macrophages requires STAT4 signaling and is inhibited by IL-4显示文摘 | SCHINDLER H LUTZ M B ROLLINGHOFF M | 2001 | J Immunol2001，166，5： | 1 |
| 17 | Transient MR changes and symptomatic epilepsy following gamma knife treatment of a residual GH-secreting pituitary adenoma in the cavernous sinus显示文摘 | Schindler K Christ ER Mindermann T | 2006 | Acta Neurochir (Wien)2006，148，8： | 1 |
| 18 | Sample preparation for total nitrogen and 15N-Rtion analysis by the automated Dumas combustion method显示文摘 | Frank V Schindler Raymond E Knighton | 1999 | Communications in soil science and plant analysis1999，30，910： | 1 |
| 19 | Diagnosis of prospective malignancy in koilocytic dysplasias of the cervix with DNA cytometry 显示文摘 | Chatelain R Schunck T Schindler EM | 1989 | J Reprod Med1989，34，8： | 1 |
| 20 | Internet forums as influential sources of consumer information显示文摘 | Bickart B Schindler R M | 2001 | Journal of Interactive Market- ing2001，15，3： | 1 |
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