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| 1 | Insulin-mimetic compound hexaquis(benzylammonium) decavanadate is antilipolytic in human fat cells显示文摘AIM To assess in rodent and human adipocytes the antilipolytic capacity of hexaquis(benzylammonium) decavanadate(B6V10), previously shown to exert antidiabetic effects in rodent models, such as lowering free fatty acids(FFA) and glucose circulating levels.METHODS Adipose tissue(AT) samples were obtained after informed consent from overweight women undergoing plastic surgery. Comparison of the effects of B6V10 and reference antilipolytic agents(insulin,benzylamine,vanadate) on the lipolytic activity was performed on adipocytes freshly isolated from rat, mouse and human AT. Glycerol release was measured using colorimetric assay as an index of lipolytic activity. The influence of B6V10 and reference agents on glucose transport into human fat cells was determined using the radiolabelled 2-deoxyglucose uptake assay.RESULTS In all the species studied, B6V10 exhibited a dosedependent inhibition of adipocyte lipolysis when triglyceride breakdown was moderately enhanced by β-adrenergic receptor stimulation. B6V10 exerted on human adipocyte a maximal lipolysis inhibition of glycerol release that was stronger than that elicited by insulin. However, B6V10 did not inhibit basal and maximally stimulated lipolysis. When incubated at dose ≥ 10 μmol/L, B6V10 stimulated by twofold the glucose uptake in human fat cells, but-similarly to benzylamine-without reaching the maximal effect of insulin, while it reproduced one-half of the insulin-stimulation of lipogenesis in mouse fat cells. CONCLUSION B6V10 exerts insulin-like actions in adipocytes, including lipolysis inhibition and glucose transport activation. B6V10 may be useful in limiting lipotoxicity related to obesity and insulin resistance. | Christian Carpéné Silvia Garcia-Vicente Marta Serrano Luc Marti ChloéBelles Miriam Royo Jean Galitzky Antonio Zorzano Xavier Testar | 2017 | World Journal of Diabetes2017，8，4： | 2 |
| 2 | Stem cell transplantation as atherapeutic strategy for traumatic brain injury 显示文摘 | Longhi L Zanier ER Royo N | 2005 | Transpl Immunol2005，15，： | 1 |
| 3 | Stem cell transplantation as a therapeutic strategy for traumatic brain injury显示文摘 | Longhi L Zanier ER Royo N | 2005 | Transpl Immunol2005，15，2： | 1 |
| 4 | A review and rationale for the use of cellular transplantation as a therapeutic strategy for traumatic brain injury 显示文摘 | Schouten J W Fulp C T Royo N C | 2004 | J Neurotrauma2004，21，： | 1 |
| 5 | Bone morphogenetic protein 15 (BMP15) alleles predict over-response to recombinant follicle stimulation hormone and iatrogenic ovarian hyperstimulation syndrome(OHSS)显示文摘 | Morón FJ de Castro F Royo JL | 2006 | Pharmacogenet Genomics2006，16，7： | 1 |
| 6 | Chromogenic and fluorogenic reagents for chemical warfare nerve agents' detection显示文摘 | Royo S Martinez-Má(n)ez R Sancenón F Costero A M Parra M Gil S | | 0，，46： | 1 |
| 7 | Local e-government 2.0: Social media and corporate transparency in municipalities显示文摘 | Enrique Bonsón Lourdes Torres Sonia Royo Francisco Flores | 2012 | Government Information Quarterly2012，，2： | 1 |
| 8 | Stem cell transplantation as a therapeutic strategy for traumatic brain injury 显示文摘 | Longhi L Zanier E Royo N | 2005 | Transpt Immunol2005，15，2： | 1 |
| 9 | Cognitive outcome following brain injury and treatment with an inhibitor of Nogo-A in association with an attenuated downregulation of hippocampal growth-associated protein-43 expression 显示文摘 | Marklund N Bareyre MF Royo CN | 2007 | Neurosurg2007，107，4： | 1 |
| 10 | Assessment of CCHP systems based on biomass combustion for small-scale applications through a review of the technology and analysis of energy efficiency parameters显示文摘 | Daniel Maraver Ana Sin Javier Royo Fernando Sebastián | 2013 | Applied Energy2013，，： | 1 |
| 11 | Cofiring versus biomass-fired power plants:GHG (Greenhouse Gases) emissions savings comparison by means of LCA (Life Cycle Assessment) methodology显示文摘 | Sebastián F Royo J G6mez M | | 0，，04： | 1 |
| 12 | Early transplantation of immortalized hippocampal progenitor cells ( MHP36 ) following experimental traumatic brain injury in rats improves motor and cognitive function at 4 months post injury 显示文摘 | Lenzlinger PM Stover JF Royo N | 2002 | Exp Neurol2002，175，2： | 1 |
| 13 | Experimental traumatic brain injury modulates the survival, migration, and terminal phenotype of transplanted epidermal growth factor receptor-activated neural stem cells 显示文摘 | Boockvar JA Schouten J Royo N | 2005 | Neurosurgery2005，56，1： | 1 |
| 14 | Stem cell transplantation as a therapeutic strategy for traumatic brain injury 显示文摘 | Longhi L Zanier E R Royo N | 2005 | Transpl Immunol2005，15，2： | 1 |
| 15 | Effect of the preparation method on the reducibility of molybdena-alumina catalysts显示文摘 | Sarrín J Noguera O Royo H | 1999 | Journal of Molecular Catalysis A:Chemical1999，144，： | 1 |
| 16 | Experimental traumatic brain injury modulates the survival,migration,and terminal phenotype of transplanted epidermal growth factor receptor-activated neural stem cells显示文摘 | Boockvar JA Schoutan J Royo N | 2005 | Neurosurgery2005，56，1： | 1 |
| 17 | Usefulness of spectral reflectance indices as durum wheat yield predictors under contrasting mediterranean conditions显示文摘 | Royo C Aparicio N Villegas D | 2003 | International Journal of Remote Sensing2003，24，22： | 1 |
| 18 | Stem cell transplantation as a therapeutic strategy for traumatic brain injury 显示文摘 | Longhi L Zanier ER Royo N | 2005 | Transpl Immunol2005，15，2： | 1 |
| 19 | Leaf and green area development of durum wheat gcnotypes grown under Mediterranean conditions显示文摘 | Royo C Aparicio N Blanco R | 2004 | European Journal of Agronomy2004，20，4： | 1 |
| 20 | Pharmacology of traumatic brain injury显示文摘 | ROYO N C SHIMIZU S SCHOUTEN J W | 2003 | Curr Opin Pharmacol2003，3，1： | 1 |
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