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| 1 | 短期针刺足三里对脂多糖诱导的大鼠急性肺损伤的预防作用(英文)显示文摘目的:研究短期手法针刺足三里治疗对脂多糖诱导的实验性大鼠急性肺损伤的预防作用。方法:根据是否进行脂多糖刺激及采用的针刺方法的不同,将32只 Wistar 大鼠随机分为4组,即正常对照组、模型组、假针刺组和针刺组,每组8只。假针刺组和针刺组大鼠行手法针刺治疗,连续治疗4 d,每次 5 min。第4天针刺后采用脂多糖刺激诱导大鼠急性肺损伤。第5天,收集外周血、支气管肺泡灌洗液和骨髓等进行白细胞计数。结果:血细胞计数和支气管肺泡灌洗液细胞计数提示,针刺可减轻急性肺损伤大鼠的炎性反应,假针刺也有轻微的效果。正常对照组和模型组大鼠无明显的炎性反应。与正常对照组比较,模型组肺泡灌洗液中细胞计数增加;与假针刺组比较,针刺组肺泡灌选液中细胞计数减少,但差异没有统计学意义。结论:预防性手法针刺足三里可减轻脂多糖诱导的大鼠急性肺损伤,但其相关免疫机制仍待进一步的研究。 | Arthur de Sá FERREIRA Januário Gomes Mourāo e LIMA Tatiana Pereira Teixeira FERREIRA Camila Madeira Tavares LOPES Rubens MEYER | 2009 | 中西医结合学报2009，7，10： | 21 |
| 2 | Computed tomography-guided percutaneous core needle biopsy in pancreatic tumor diagnosis显示文摘AIM: To evaluate the techniques, results, and complications related to computed tomography(CT)-guided percutaneous core needle biopsies of solid pancreatic lesions.METHODS: CT-guided percutaneous biopsies of solid pancreatic lesions performed at a cancer reference center between January 2012 and September 2013 were retrospectively analyzed. Biopsy material was collected with a 16-20 G Tru-Core needle(10-15 cm; Angiotech, Vancouver, CA) using a coaxial system and automatic biopsy gun. When direct access to the lesion was not possible, indirect(transgastric or transhepatic) access or hydrodissection and/or pneumodissection maneuvers were used. Characteristics of the patients, lesions, procedures, and histologic results were recorded using a standardized form. RESULTS: A total of 103 procedures included in the study were performed on patients with a mean age of 64.8 year(range: 39-94 year). The mean size of the pancreatic lesions was 45.5 mm(range: 15-195 mm). Most(75/103, 72.8%) procedures were performed via direct access, though hydrodissection and/or pneumodissection were used in 22.2%(23/103) of cases and indirect transhepatic or transgastric access was used in 4.8%(5/103) of cases. Histologic analysis was performed on all biopsies, and diagnoses were conclusive in 98.1%(101/103) of cases, confirming3.9%(4/103) of tumors were benign and 94.2%(97/103) were malignant; results were atypical in 1.9%(2/103) of cases, requiring a repeat biopsy to diagnose a neuroendocrine tumor, and surgical resection to confirm a primary adenocarcinoma. Only mild/moderate complications were observed in 9/103 patients(8.7%),and they were more commonly associated with biopsies of lesions located in the head/uncinate process(n =8), than of those located in the body/tail(n = 1) of the pancreas, but this difference was not significant.CONCLUSION: CT-guided biopsy of a pancreatic lesion is a safe procedure with a high success rate, and is an excellent option for minimally invasive diagnosis. | Chiang J Tyng Maria Fernanda A Almeida Paula NV Barbosa Almir GV Bitencourt José Augusto AG Berg Macello S Maciel Felipe JF Coimbra Luiz Henrique O Schiavon Maria Dirlei Begnami Marcos D Guimares Charles E Zurstrassen Rubens Chojniak | 2015 | World Journal of Gastroenterology2015，21，12： | 14 |
| 3 | Towards a new tuberculosis drug: pyridomycin – nature’s isoniazid显示文摘 | Ruben C. Hartkoorn Claudia Sala Jo?o Neres Florence Pojer Sophie Magnet Raju Mukherjee Swapna Uplekar Stefanie Boy‐R?ttger Karl‐Heinz Altmann Stewart T. Cole | 2012 | EMBO Mol Med2012，，： | 2 |
| 4 | 策略将在肝移植以后减少丙肝病毒复发显示文摘 Hepatitis C virus (HCV) is a major health problem that leads to chronic hepatitis, cirrhosis and hepatocellular carcinoma, being the most frequent indication for liver transplantation in several countries. Unfortunately, HCV re-infects the liver graft almost invariably following reperfusion, with an accelerated history of recurrence, leading to 10%-30% of patients progressing to cirrhosis within 5 years of transplantation. In this sense, some groups have even advocated for not retransplanting this patients, as lower patient and graftoutcomes have been reported. However, the management of HCV recurrence is being optimized and several strategies to reduce post-transplant recurrence could improve outcomes, decrease the rate of re-transplantation and optimize the use of available grafts. Three moments may be the focus of potential actions in order to decrease the impact of viral recurrence: the pretransplant moment, the transplant environment and the post-transplant management. In the pre-transplant setting, it is not well established if reducing the pre transplant viral load affects the risk for HCV progression after transplant. Obviously, antiviral treatment can render the patient HCV RNA negative post transplant but the long-term benefit has not yet been fully established to justify the cost and clinical risk. In the transplant moment, factors as donor age, cold ischemia time, graft steatosis and ischemia/reperfusion injury may lead to a higher and more aggressive viral recurrence. After the transplant, discussion about immunosuppression and the moment to start the treatment (prophylactic, pre-emptive or once-confirmed) together with new antiviral drugs are of interest. This review aims to help clinicians have a global overview of posttransplant HCV recurrence and strategies to reduce its impact on our patients. | Ruben Ciria María Pleguezuelo Shirin Elizabeth Khorsandi Diego Davila Abid Suddle Hector Vilca-Melendez Sebastian Rufian Manuel de la Mata Javier Briceo Pedro López Cillero Nigel Heaton | 2013 | World Journal of Hepatology2013，5，5： | 2 |
| 5 | Identification of radiological alveolar pneumonia in children with high rates of hospitalized respiratory infections:comparison of WHO-defined and pediatric pulmonologist diagnosis in the clinical context显示文摘 | O'Grady KA Torzillo PJ Ruben AR | 2012 | Pediatr Pulmonol2012，47，4： | 1 |
| 6 | High doses of Ketamine- Xylazine anesthesia reduce cardiac isehemia-reperfusion injury in guinea pigs显示文摘 | Ruben C Matthew R Dorcas O | 2011 | J Am Assoe Lab Anita Sci2011，50，3： | 1 |
| 7 | Dynamic characteristics of a long span seismic isolated bridge 显示文摘 | Boroschek Ruben L Moroni Mafia O Sarrazin Mauricio | 2003 | Engineering Structures2003，，25： | 1 |
| 8 | Regularization methods for ill- posed problems in multiple Hilbert scales 显示文摘 | Gisela M L Ruben S O | 2012 | Inverse Problems2012，28，5： | 1 |
| 9 | Gene expression microarrays: a 21st century tool for directed vaccine design显示文摘 | NEELAM D RUBEN B DENNIS O | 2002 | Vaccine2002，20，： | 1 |
| 10 | Optical properties of metal nanoparticles with arbitrary shapes显示文摘 | Ivan O Sosa Cecila Noguez Ruben G Barrera | 2003 | Journal of Physical Chemistry B2003，107，26： | 1 |
| 11 | New method to assess barley nitrogen nutrition status based on image colour analysis Comparison with SPAD-502显示文摘 | MIGUEL P RUBEN O IGNACIO I | 2009 | Computers and Electronics in Agriculture2009，65，2： | 1 |
| 12 | The assessment of water quality in the lower Lujan river ( Buenos Aires, Argentina ): phytoplankton and algal bioassays 显示文摘 | INES O RUBEN J L PAULA T P | 2002 | Environmental Pollution2002，120，2： | 1 |
| 13 | Cursoriallity in bipedal archosaurs显示文摘 | Jones T D Farlow J O Ruben J A | 2000 | Nature2000，406，： | 1 |
| 14 | Endoscopic Detection of Early Esophageal Squamous Cell Carcinoma in Patients with Achalasia: Narrow-Band Imaging versus Lugol’s Staining显示文摘 | Edson Ide Fred Olavo Arag?o Andrade Carneiro Mariana Souza Varella Fraz?o Dalton Marques Chaves Rubens Ant?nio Aissar Sallum Eduardo Guimar?es Hourneaux de Moura Paulo Sakai Ivan Cecconello Fauze Maluf-Filho Everson L. A. Artifon | 2013 | Journal of Oncology2013，，： | 1 |
| 15 | Cyclophilin D is a component of mito- chondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia显示文摘 | SCHINZEL AC TAKEUCHI O HUANG Z FISHER JK ZHOU Z RUBENS J | 2005 | Proc Natl Acad Sci2005，102，12： | 1 |
| 16 | Sialylation of group B streptococcal capsular polysacchm'ide is mediated by cpsK and is required for optimal capsule polymerization and expression显示文摘 | Chall]n D O Mentele L M Rubens C E | 2005 | Journal of Bacteriology2005，187，13： | 1 |
| 17 | Supermarkets and their impacts on the agfifood system of Brazil : the competition among retailers 显示文摘 | Elizabeth M M O Farina Rubens Nunes Guilherme F de A Monteiro | 2005 | Agribusiness2005，21，2： | 1 |
| 18 | The Application of Fuzzy Logic to the Construc- tion of the Ranking Function of Information Retrieval Systems显示文摘 | Rubens N O | 2006 | Computer Modelling and New Technologies2006，10，1： | 1 |
| 19 | Sialylation of group B streptococcal capsular polysaccharide is mediated by cpsK and is required for optimal capsule polymerization and expression显示文摘 | Chaffin D O Mentele L M Rubens C E | 2005 | Journal of Bacteriology2005，187，13： | 1 |
| 20 | Blue/white screening of recombinant plasmids in Gram-positive bacteria by interruption of alkaline phosphatase gene (phoZ) expression显示文摘 | CHAFFIN D O RUBENS C E | | 0，，： | 1 |
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