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| 1 | Cerebral radiation necrosis: incidence, outcomes, and risk factors with emphasis on radiation parameters and chemotherapy显示文摘 | Ruben JD Dally M Bailey M Smith R McLean CA Fedele P | 2006 | 中国神经肿瘤杂志2006，4，3： | 15 |
| 2 | Oncogenic role of leptin and Notch interleukin-1 leptin crosstalk outcome in cancer显示文摘Obesity is a global pandemic characterized by high levels of body fat(adiposity) and derived-cytokines(i.e., leptin). Research shows that adiposity and leptin provide insight on the link between obesity and cancer progression. Leptin's main function is to regulate energy balance. However, obese individuals routinely develop leptin resistance, which is the consequence of the breakdown in the signaling mechanism controlling satiety resulting in the accumulation of leptin. Therefore, leptin levels are often chronically elevated in human obesity. Elevated leptin levels are related to higher incidence, increased progression and poor prognosis of several human cancers. In addition to adipose tissue, cancer cells can also secrete leptin and overexpress leptin receptors. Leptin is known to act as a mitogen, inflammatory and pro-angiogenic factor that induces cancer cell proliferation and tumor angiogenesis. Moreover, leptin signaling induces cancer stem cells, which are involved in cancer recurrence and drug resistance. A novel and complex signaling crosstalk between leptin, Notch and interleukin-1(IL-1) [Notch, IL-1 and leptin crosstalk outcome(NILCO)] seems to be an important driver of leptin-induced oncogenic actions. Leptin and NILCO signaling mediate the activation of cancer stem cells that can affect drug resistance. Thus, leptin and NILCO signaling are key links between obesity and cancer progression. This review presents updated data suggesting that adiposity affects cancer incidence, progression, and response to treatment. Here we show data supporting the oncogenic role of leptin in breast, endometrial, and pancreatic cancers. | Crystal C Lipsey Adriana Harbuzariu Danielle Daley-Brown Ruben R Gonzalez-Perez | 2016 | World Journal of Methodology2016，6，1： | 8 |
| 3 | Leptin signaling and cancer chemoresistance:Perspectives显示文摘Obesity is a major health problem and currently is endemic around the world. Obesity is a risk factor for several different types of cancer, significantly promoting cancer incidence, progression, poor prognosis and resistance to anti-cancer therapies. The study of this resistance is critical as development of chemoresistance is a serious drawback for the successful and effective drug-based treatments of cancer. There is increasing evidence that augmented adiposity can impact on chemotherapeutic treatment of cancer and the development of resistance to these treatments, particularly through one of its signature mediators, the adipokine leptin. Leptin is a pro-inflammatory, pro-angiogenic and pro-tumorigenic adipokine that has been implicated in many cancers promoting processes such as angiogenesis, metastasis, tumorigenesis and survival/resistance to apoptosis. Several possible mechanisms that could potentially be developed by cancer cells to elicit drug resistance have been suggested in the literature. Here, we summarize and discuss the current state of the literature on the role of obesity and leptin on chemoresistance, particularly as it relates to breast and pancreatic cancers. We focus on the role of leptin and its significance in possibly driving these proposed chemoresistance mechanisms, and examine its effects on cancer cell survival signals and expansion of the cancer stem cell sub-populations. | Pierre V Candelaria Antonio Rampoldi Adriana Harbuzariu Ruben R Gonzalez-Perez | 2017 | World Journal of Clinical Oncology2017，8，2： | 6 |
| 4 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 5 | Histone deacetylases,microRNA and leptin crosstalk in pancreatic cancer显示文摘Because pancreatic cancer(PC) historically has had poor prognosis and five year survival rates,it has been intensely investigated.Analysis of PC incidence and biology has shown a link between different risk factors such as smoking,alcoholism,and obesity and disease progression.Important factors affecting PC include the epigenomic changes driven by DNA methylation and histone acetylation,and actions of microRNA inducing oncogenic or tumor suppressor effects.Studies have identified markers whose dysregulation seem to play important roles in PC progression.PC markers involve classical histone deacetylases(HDAC),PC stem cell(PCSC),and leptin.In this review,we discuss the role of several PC biomarkers,and the potential crosstalk between HDAC,microRNA,and leptin in PC progression.Dysregulated expression of these molecules can increase proliferation,survival,PCSC,resistance to chemotherapy and tumor angiogenesis.The potential relationships between these molecules are further analyzed using data from The Cancer Genome Atlas and crosstalk pathways generated by the Pathway Studio Platform(Ariadne Genomics,Inc.).Oncogenic miRNA21 and tumor suppressor miRNA200 have been previously linked to leptin signaling.Preliminary analysis of PC biopsies and signaling crosstalk suggests that the main adipokine leptin could affect the expression of microRNA and HDAC in PC.Data analysis suggests that HDAC-microRNA-leptin signaling crosstalk may be a new target for PC therapy. | Cynthia I Tchio Mantho Adriana Harbuzariu Ruben R Gonzalez-Perez | 2017 | World Journal of Clinical Oncology2017，8，3： | 2 |
| 6 | Towards a new tuberculosis drug: pyridomycin – nature’s isoniazid显示文摘 | Ruben C. Hartkoorn Claudia Sala Jo?o Neres Florence Pojer Sophie Magnet Raju Mukherjee Swapna Uplekar Stefanie Boy‐R?ttger Karl‐Heinz Altmann Stewart T. Cole | 2012 | EMBO Mol Med2012，，： | 2 |
| 7 | Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial显示文摘 | Edward B Garon Tudor-Eliade Ciuleanu Oscar Arrieta Kumar Prabhash Konstantinos N Syrigos Tuncay Goksel Keunchil Park Vera Gorbunova Ruben Dario Kowalyszyn Joanna Pikiel Grzegorz Czyzewicz Sergey V Orlov Conrad R Lewanski Michael Thomas Paolo Bidoli Shaker | 2014 | The Lancet2014，，： | 2 |
| 8 | Oxidation of thioacetamide by ferrate(VI)显示文摘 | Frank J M | 2000 | Marine Chemistry2000，70，1： | 1 |
| 9 | High doses of Ketamine- Xylazine anesthesia reduce cardiac isehemia-reperfusion injury in guinea pigs显示文摘 | Ruben C Matthew R Dorcas O | 2011 | J Am Assoe Lab Anita Sci2011，50，3： | 1 |
| 10 | Modeling and simulation of lithium-ion batteries 显示文摘 | ERNESTO M R RUBEN V M ANTONIO F T | 2011 | Computers and Chemical Engineering2011，35，1： | 1 |
| 11 | A comprehensive review and evaluation of permutation flowshop heuristies显示文摘 | RUBEN R MAROTO C | 2005 | European Journal of Operational Research2005，165，2： | 1 |
| 12 | A polysomnographic pla- cebo-controlled evaluation of efficacy and safety of eszopiclone relative to placebo and zolpidem in the treatment of primary in-somnia显示文摘 | Erman MK Zammit G Rubens R | 2008 | JClinSleepMed2008，4，2： | 1 |
| 13 | The inflation-hedging effectiveness of real estate 显示文摘 | Rubens J H Bond M T Webb J R | 1989 | Journal of Real Estate Research1989，2，4： | 1 |
| 14 | A simple and effective iterated greedy algo- rithm for the permutation flow shop scheduling problem 显示文摘 | RUBEN R THOMAS S | 2007 | Euro- pean Journal of Operational Research2007，177，3： | 1 |
| 15 | High-resolution transmission electron microscopy of the nanostructure of melamine-formaldehyde aerogels显示文摘 | Ruben G C Pekala R W | 1995 | JNon-Crystalline Solids1995，186，： | 1 |
| 16 | Diagnosis of deafness in infancy 显示文摘 | RUBEN R J | 1987 | Pediatr Rev1987，9，5： | 1 |
| 17 | A polysom nographic p lacebo2 controlled evaluation of the efficacy and safety of eszopiclone relative to placebo and zolpidem in the treatment of primary insomnia 显示文摘 | Erman MK Zammit G Rubens R | 2008 | J Clin Sleep Med2008，4，3： | 1 |
| 18 | 'Land rental market, off-farmemployment and agricultural production in Southeast China: A plot-level case study' 显示文摘 | Feng S Y Heerink N Ruben R | 2010 | China Economic Review2010，21，4： | 1 |
| 19 | In vitro propagation of the endangered plant Centaurea ultreiae : assessment of genetic stability by cytological studies, flow cytometry and RAPD analysis显示文摘 | Ruben M Juan R Maria L G | 2010 | Plant Cell Tiss Org2010，101，1： | 1 |
| 20 | Analytical framework for disentangling the concept of sustainable land use显示文摘 | Ruben R Kuyvenhoven A | 1996 | Agricultural Systems1996，，5： | 1 |
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