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| 1 | Computed tomography-guided percutaneous core needle biopsy in pancreatic tumor diagnosis显示文摘AIM: To evaluate the techniques, results, and complications related to computed tomography(CT)-guided percutaneous core needle biopsies of solid pancreatic lesions.METHODS: CT-guided percutaneous biopsies of solid pancreatic lesions performed at a cancer reference center between January 2012 and September 2013 were retrospectively analyzed. Biopsy material was collected with a 16-20 G Tru-Core needle(10-15 cm; Angiotech, Vancouver, CA) using a coaxial system and automatic biopsy gun. When direct access to the lesion was not possible, indirect(transgastric or transhepatic) access or hydrodissection and/or pneumodissection maneuvers were used. Characteristics of the patients, lesions, procedures, and histologic results were recorded using a standardized form. RESULTS: A total of 103 procedures included in the study were performed on patients with a mean age of 64.8 year(range: 39-94 year). The mean size of the pancreatic lesions was 45.5 mm(range: 15-195 mm). Most(75/103, 72.8%) procedures were performed via direct access, though hydrodissection and/or pneumodissection were used in 22.2%(23/103) of cases and indirect transhepatic or transgastric access was used in 4.8%(5/103) of cases. Histologic analysis was performed on all biopsies, and diagnoses were conclusive in 98.1%(101/103) of cases, confirming3.9%(4/103) of tumors were benign and 94.2%(97/103) were malignant; results were atypical in 1.9%(2/103) of cases, requiring a repeat biopsy to diagnose a neuroendocrine tumor, and surgical resection to confirm a primary adenocarcinoma. Only mild/moderate complications were observed in 9/103 patients(8.7%),and they were more commonly associated with biopsies of lesions located in the head/uncinate process(n =8), than of those located in the body/tail(n = 1) of the pancreas, but this difference was not significant.CONCLUSION: CT-guided biopsy of a pancreatic lesion is a safe procedure with a high success rate, and is an excellent option for minimally invasive diagnosis. | Chiang J Tyng Maria Fernanda A Almeida Paula NV Barbosa Almir GV Bitencourt José Augusto AG Berg Macello S Maciel Felipe JF Coimbra Luiz Henrique O Schiavon Maria Dirlei Begnami Marcos D Guimares Charles E Zurstrassen Rubens Chojniak | 2015 | World Journal of Gastroenterology2015，21，12： | 14 |
| 2 | Double-balloon enteroscopy-assisted dilatation avoids surgery for small bowel strictures: A systematic review显示文摘AIM To evaluate the therapeutic role of double-balloon enteroscopy(DBE) in small bowel strictures and to propose a standard approach to small bowel strictures.METHODS Systematic review of studies involving DBE in patients with small bowel strictures. Only studies limited to small bowel strictures were included and those with ileo-colonic strictures were excluded. RESULTS In total 13 studies were included,in which 310 patients were dilated. The average follow-up time was 31.8 mo per patient. The complication rate was 4.8% per patient and 2.6% per dilatation. Surgery was avoided in 80% of patients. After the first dilatation,46% were treated with re-dilatation and only 17% required surgery.CONCLUSION DBE-assisted dilatation avoids surgery in 80% of patients with small bowel strictures and is safe and effective. We propose a standardized approach to small bowel strictures. | Judith E Baars Ruben Theyventhiran Patrick Aepli Payal Saxena Arthur J Kaffes | 2017 | World Journal of Gastroenterology2017，23，45： | 6 |
| 3 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 4 | 西班牙交通基础设施与城市体系建设显示文摘从社会和地方融合、均衡性与土地异质性、交通网等级体系和支路网与交通可持续性四个角度探讨西班牙交通基础设施网建设对土地开发和土地规划相关国家法规的影响。从城市地理学视角分析中央政府基于改善城市和区域连接度和可达性进行的高速公路网、高铁网、机场和港口等交通基础设施规划,通过1950年代以来土地开发和房价涨跌、新兴产业培育和交通状况改善刺激不同级别城市蔓延和分化的人口增长,重塑西班牙国家城市体系格局。随后,概括了蔓延的城市增长模式和房地产与交通投资泡沫破裂后带给区域增长中心的影响,对通过交通基础设施规划进行投机性投资政策进行了批评。最后建议中央政府应该避免投机投资行为,基于现有的城市体系层级改善核心城市和大城市周边的机动性,优化基础设施建设,建立新的城市与区域增长模式。 | Lois-Gonzalez Ruben C Pineira-Mantinan M J 翟炜 顾朝林 | 2016 | 地理研究2016，35，7： | 3 |
| 5 | 向在人的察觉到钙的受体的 allosteric 药的结构的理解显示文摘allosterically 指向人的察觉到钙的受体(CaSR ) 的药有实质的治疗学的潜力,但是当前被限制。给 CaSR 的高分辨率的结构的缺席,我们把 mutagenesis 与一条新奇分析途径并且开发 “ 的分子的建模相结合; enriched”为在 Ca 2+ 在 CaSRs 7 transmembrane (7TM ) 以内的 o 和 allosteric 调节的人领域。修改多重有约束力的地点以适应在结构上的一个扩大的洞多样的 ligands 被识别。Phenylalkylamines 绑在与通常认为的 Ca 2+ o -binding 地点并且向一个细胞外的门厅延长。相反,在结构上和 pharmacologically 不同的 AC-265347 在 7TM 领域以内更深绑。而且,不同氨基酸网络被发现调停由不同调节的人的 cooperativity。这些调查结果可以与不同、潜在地偏导小径的药理学效果便于 allosteric 调节的人的合理设计。 | Katie Leach Karen J Gregory Irina Kufareva Elham Khajehali Anna E Cook Ruben Abagyan Arthur D Conigrave Patrick M Sexton Arthur Christopoulos | 2016 | Cell Research2016，26，5： | 2 |
| 6 | Gas-phase transformations of mercury in coal-fired power plants显示文摘 | Constance L Senior Adel F Sarofim Taofang Zeng Joseph J Helble Ruben Mamani-Paco | 2000 | Fuel Processing Technology2000，，2： | 2 |
| 7 | Oxidation of thioacetamide by ferrate(VI)显示文摘 | Frank J M | 2000 | Marine Chemistry2000，70，1： | 1 |
| 8 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 9 | Microradiography and confacal laser scanning microscopy applied to enamel lesions formed in vivo with and without fluoride varnish treatment显示文摘 | Ogaard B Duschner H Ruben J | 1996 | Eur J Oral Sci1996，104，4： | 1 |
| 10 | The role of dendritic cells in the pathogenesis of systemic lupus erythematosus 显示文摘 | Fransen J H van der Vlag J Ruben J | 2010 | Ar- thritis Res Ther2010，12，4： | 1 |
| 11 | Three-dimensional registration and fusion of ultrasound and MRI using major vessels as fiducial markers显示文摘 | Porter B C Rubens D J Strang J G | | 0，，04： | 1 |
| 12 | Soft sensors development for on-line bioreactor state estimation显示文摘 | AJILSON J D A RUBENS M F | 2000 | Computers and Chemical Engineering2000，24，： | 1 |
| 13 | Sequence analysis of expressed sequence tags from an ABA-treated cDNA library identifies stress response genes in the moss Physcomitrella patterns显示文摘 | Machuka J Bashiardes S Ruben E Spooner K Cuming A Knight C Cove D | 1999 | Plant Cell Physiol1999，40，4： | 1 |
| 14 | Comparative study on volatile analysis of extra virgin olive oil by dynamic headspace and solid phase micro-extraction显示文摘 | Antonis K Apostolos K Ruben J H | 2005 | Food Chemistry2005，90，： | 1 |
| 15 | Individual variation in susceptibility to extracranial carotid atherosclerosis显示文摘 | Rubens J Espeland MA Ryu T | 1988 | Arterioclerosis1988，8，4： | 1 |
| 16 | Major topics in quantitative microradiography of enamel and dentin: Parameter, mineral distribution visualization, and hyper-remineralization显示文摘 | Arends J Ruben JL lnaba D | 1997 | Adv Dent Res1997，11，4： | 1 |
| 17 | The role of dendritic cells in the pathogenesis of systemic lupus erythematosus显示文摘 | Fransen JH van der Vlag J Ruben J | | 0，，： | 1 |
| 18 | Electron probe microanalysis and transverse microradiography studies of artificial lesion in enamel and dentin: a comparative study 显示文摘 | Ngo H Ruben J Arends J | 1997 | Adv Dent Res1997，11，： | 1 |
| 19 | Electron probe microanalysis and transverse microradiography study of artificial lesions in enamel and dentin:a comparative study显示文摘 | Ngo H Ruben J Arends J | 1997 | Adv Dent Res1997，11，4： | 1 |
| 20 | In situ observation of pressure-induced gelation of starches studied with FTIRin the diamond anvil cell显示文摘 | P Rubens J Snauwaert K Heremans | 1999 | Carbohydrate Polymers1999，39，3： | 1 |
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