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| 1 | Economic Liberalization and Wage Inequality in India显示文摘 | Rubiana Chamarbagwala | 2006 | World Development2006，34，3： | 1 |
| 2 | PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution显示文摘 | Rubiana M. Mainardes Raul C. Evangelista | 2004 | International Journal of Pharmaceutics2004，，1： | 1 |
| 3 | Liposomes and micro/nanoparticles as colloidal carriers for nasal drug delivery 显示文摘 | RUBIANA MM MARIA CCU PRISCILA OC | 2006 | Curr Drug Deliv2006，3，3： | 1 |
| 4 | PLGA nanoparticles containing praziquantel :effect of formulation variables on size distribution 显示文摘 | Rubiana M Raul C | 2005 | Int J Pharm2005，290，： | 1 |
| 5 | Manufacture of Standardized Dried Extracts from Medicinal Brazilian Plants显示文摘 | Wanderley P. Oliveira Rubiana F. Bott Claudia R. F. Souza | 2006 | Drying Technology2006，，4： | 1 |
| 6 | Application of a validated HPLC-PDA method for the determination of melatonin content and its release from poly(lactic acid)nanoparticles显示文摘Melatonin is a natural hormone and with the advancement of age its production declines and thereby may result in some neurological disorders. Exogenous administration of melatonin has been suggested as a neuroprotective agent. Due to its low oral bioavailability, the loading of melatonin in polymeric nanoparticles could be an important tool to effectively use exogenous melatonin. The quantification of the incorporated drug within polymeric nanoparticles is an important step in nanoparticles characterization. An analytical method using high performance liquid chromatography equipped with photodiode array detector(HPLC-PDA) was developed and validated for melatonin determination in poly(lactic acid) nanoparticles obtained by a single emulsion-solvent evaporation technique. The melatonin in vitro release profile also was determined by the HPLC method. Mobile phase consisted of acetonitrile: water(65:35, v/v) pumped at a flow rate of 0.9 mL/min, in the isocratic mode and PDA detector was set at 220 nm. The method was validated in terms of the selectivity, linearity, precision,accuracy, robustness, limits of detection and quantification. Analytical curve was linear over the concentration range of 10–100 μg/mL, and limits of detection and quantification were 25.9 ng/mL and 78.7 ng/mL,respectively. The mean recovery for melatonin was 100.47%(RSD = 1.25%, n = 9). In the intra-and interassay, the coefficient of variation was less than 2%. Robustness was proved performing changes in mobile phase,column temperature and flow rate. The method was suitable for the determination of melatonin encapsulation efficiency in poly(lactic acid) nanoparticles and for the evaluation of melatonin in vitro release profile. | Leiziani Gnatkowski Martins Najeh Maissar Khalil Rubiana Mara Mainardes | 2017 | Journal of Pharmaceutical Analysis2017，7，6： | 1 |
| 7 | A stability-indicating high performance liquid chromatography method to determine apocynin in nanoparticles显示文摘In this study, we developed and validated a fast, specific, sensitive, precise and stability-indicating high performance liquid chromatography(HPLC) method to determine the drug apocynin in bovine serum albumin(BSA) nanoparticles. Chromatographic analyses were performed on an RP C18 column and using a photodiode array detector at a wavelength of 276 nm. Mobile phase consisted of a mixture of acetonitrile and 1% acetic acid(60:40, v/v), and it was eluted isocratically at a flow rate of 0.8 mL/min. The retention time of apocynin chromatographic peak was 1.65 min. The method was linear, precise, accurate and specific in the range of 5–100 μg/mL. The intra-and inter-day precisions presented relative standard deviation(RSD) values lower than 2%. The method was robust regarding changes in mobile phase proportion, but not for flow rate. Limits of detection and quantitation were 78 ng/mL and 238 ng/mL, respectively. Apocynin was exposed to acid and alkali hydrolysis, oxidation and visible light. The drug suffered mild degradation under acid and oxidation conditions and great degradation under alkali conditions. Light exposure did not degrade the drug. The method was successfully applied to determine the encapsulation efficiency of apocynin in BSA nanoparticles. | Juliana Kovalczuk de Oliveira Débora Fernanda Veres Ronik Jociani Ascari Rubiana Mara Mainardes Najeh Maissar Khalil | 2017 | Journal of Pharmaceutical Analysis2017，7，2： | 0 |
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