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| 1 | Early-onset colorectal cancer:A separate subset of colorectal cancer显示文摘Colorectal cancer(CRC)has a great impact on the world population.With increasing frequency,CRC is described according to the presenting phenotype,based on its molecular characteristics.Classification of CRC tumors according to their genetic and/or epigenetic alterations is not only important for establishing the molecular bases of the disease,but also for predicting patient outcomes and developing more individualized treatments.Early-onset CRC is a heterogeneous disease,with a strong familial component,although the disease is sporadic in an important proportion of cases.Different molecular alterations appear to contribute to the apparent heterogeneity of the early-onset population and subgroups can be distinguished with distinct histopathologic and familial characteristics.Moreover,compared with late-onset CRC,there are characteristicsthat suggest that early-onset CRC may have a different molecular basis.The purpose of this review was to analyze the current state of knowledge about earlyonset CRC with respect to clinicopathologic,familial and molecular features.Together,these features make it increasingly clear that this subset of CRC may be a separate disease,although it has much in common with late-onset CRC. | Irene Osorio Silla Daniel Rueda Yolanda Rodríguez Juan Luis García Felipe de la Cruz Vigo José Perea | 2014 | World Journal of Gastroenterology2014，20，46： | 4 |
| 2 | Efficacy and Safety of Peginterferon-α2b and Ribavirin Combination Therapy in Children With Chronic Hepatitis C Infection显示文摘 | Paloma Jara Loreto Hierro Angela de la Vega Carmen Díaz Carmen Camarena Esteban Frauca Gema Mu?oz-Bartolo Ruth Díez-Dorado Concepción Ladrón de Guevara Javier Larrauri Magdalena Rueda | 2008 | The Pediatric Infectious Disease Journal2008，，2： | 1 |
| 3 | A susceptibility locus for epidermodysplasia verruciformis, an abnormal predisposition to infection with the oncogenic human papillomavirus type 5, maps to chromosome 17qter in a region containing a psoriasis locus 显示文摘 | Ramoz N Rueda LA Bouadjar B | 1999 | J Invest Dermatol1999，112，3： | 1 |
| 4 | Mutations in two adjacent novel genes are associated with epidermodysplasia verrueiformis显示文摘 | Ramoz N Rueda LA Bouadjar B | 2002 | Nat Genet2002，32，4： | 1 |
| 5 | Mutations in two adja- cent novel genes are associated with Epidermodysplasia verruci- formis显示文摘 | Ramoz N Rueda LA Bouadjar B | 2002 | Nat Genet2002，32，4： | 1 |
| 6 | Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis显示文摘 | Ramoz N Rueda LA Bouadjar B Montoya LS Orth G Favre M | | 0，，： | 1 |
| 7 | A functional variant in the CD209 promoter is associated with DQ2-negative celiac disease in the Spanish population显示文摘瞄准:在乳糜泻(CD ) 探讨 CD209 的角色病人。非人类的白血球抗原(HLA ) 在 CD 倾向的基因因素糟糕被理解,并且象传染病原体一样的环境因素可以起一个作用。CD209 是一树枝状并且涉及病原体识别和有免疫力的激活的巨噬细胞表面分子。最近,在 CD209 基因的倡导者的功能的变体(-336A/G) 被显示了影响 transcriptional CD209 活动在试管内,它与感染的更高的危险性 to/or 严厉被联系了。方法:学习人口由 103 和 386 个 CD 病人和 312 y 的二个盒子控制队组成象 257 个腹的家庭的一块面板一样的 419 健康控制。为 -336A/G CD209 倡导者多型性的 Genotyping 用 TaqMan 5' 被执行突变而产生之遗传的辨别试金。HLA-DQ 被杂交与等位基因 specific 探针决定。结果:开始,盒子控制和家庭研究没与 CD 危险性发现 -336 A/G CD209 基因变体的任何协会。然而,由 HLA-DQ2 的层化确实在 HLA-DQ2 (-) 组揭示了 CD209 倡导者多型性的一个重要协会(在 DQ2 (-) 对 DQ2 (+) 病人的搬运人 A 对 GG (P = 0.026,或 = 3.71 ) 。结论:-336G CD209 等位基因似乎在 HLA-DQ2 (-) 病人涉及 CD 危险性。我们的结果可能在 CD 病人的一个次要的组的发作建议病原体的一个可能的角色。 | C Nú■ez B Rueda A Martínez C Maluenda I Polanco MA López-Nevot E Ortega E Sierra E Gómez de la Concha E Urcelay J Martín | 2006 | World Journal of Gastroenterology2006，12，27： | 1 |
| 8 | Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis显示文摘 | Ramoz N Rueda LA Bouadjar B | | 0，，32： | 1 |
| 9 | Evidence for a nonallelic heterogeneity of epidermodysplasia verruciformis with two suscep- tibility loci mapped to chromosome regions 2p21-p24 and 17q25 显示文摘 | Ramoz N Taieb A Rueda LA | 2000 | J Invest Dermatol2000，114，6： | 1 |
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