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| 1 | Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner显示文摘遇到 hypoxic 应力的房间由 downregulating 保存资源和精力蛋白质合成。这里我们 demonstratethat 在这回答的一机制是最高的 mRNAs 的翻译压抑编码 translationalapparatus 的部件。规定的这个模式包含 TSC 和 Rheb,当 Rheb 的 TSC1 或 TSC2 或 overexpression 的大美人在剥夺氧的房间救了最高的 mRNA 翻译。导致压力的翻译 repressionof 这些 mRNAs 密切与 4E-BP 的 hypophosphorylated 状态相关,一个翻译抑压者。然而, seriesof 4E-BP loss-of-function 和 gain-of-function 实验在氧或生长因素剥夺下面反驳在 phosphorylation statusof 4E-BP 和最高的 mRNAs 的翻译压抑之间的一种 cause-and-effect 关系。而且,血缺氧的 repressiveeffect 类似于由 Torin 1,而是更多 pronouncedthan 猛禽或 rictor 大美人由 mTOR 活动的有效抑制到达了那。同样,猛禽或 rictor 的缺乏它温和地 downregulated TOPmRNAs 的基础翻译效率,没能压制最高的 mRNAs 的调停氧的翻译激活。最后, TIA-1 和 TIAR co 击倒,二 RNA 有约束力的蛋白质以前在氨基的酸饥饿的房间在最高的 mRNAs 的翻译压抑含有, failedto 在另外的压力条件下面减轻最高的 mRNA 翻译。因此,近似翻译管理者 ofTOP mRNAs 的性质留下逃犯。 | Rachel Miloslavski Elad Cohen Adam Avraham Yifat I luz Zvi Hayouka Judith Kasir Rajini Mudhasani Stephen N. Jones Nadine Cybulski Markus A. Ruegg Ola Larsson Valentina Gandin Arjuna Rajakumar Ivan Topisirovic Oded Meyuhas | 2014 | Journal of Molecular Cell Biology2014，8，3： | 3 |
| 2 | Helv Chim Acta显示文摘 | Ruegg R Gliir U Goel R N | 1959 | 42:2616-26201959，42，： | 1 |
| 3 | Adult lung side population cells have mesenchymal stem cell potential 显示文摘 | Martin J Helm K Ruegg P | 2008 | Cytotherapy2008，10，2： | 1 |
| 4 | Endothelial cell integrins and COX-2: mediators and theraputic targets of tumor angiogenesis显示文摘 | Ruegg C Dormond O Mariotti A | 2004 | Biochim Biophys Acta2004，1654，1： | 1 |
| 5 | Conduction ve- locity of nerve and muscle fiber action potentials after a space mission or a bed rest 显示文摘 | Ruegg DG Kakebeeke TH Gabriel JP | 2003 | Clinical Neurophysiology2003，114，1： | 1 |
| 6 | Role of superoxide as a signaling molecule显示文摘 | Buetler T M Krauskopf A Ruegg U T | 2004 | Physiology2004，19，3： | 1 |
| 7 | Neurofilament heavy chain and heat shock protein 70 as markers of seizure- related brain injury 显示文摘 | Rejdak K Kuhle J Ruegg S | 2012 | Epilepsia2012，53，5： | 1 |
| 8 | The transcription factor aryl hydrocarbon receptor nuclear trans-locator functions as an estrogen receptor beta-selective coactivator,and its recruitment to alternative pathways mediates antiestrogenic effects of dioxin显示文摘 | Ruegg J Swedenborg E Wahlstrom D | 2008 | Molecular Endocrinology2008，22，2： | 1 |
| 9 | Estrogenic activity assessment of environmental chemicals using in vitro assays: identification of two new estrogenic compounds 显示文摘 | LASCOMBE I BEFFA D RUEGG U | 2000 | Environ Health Perspect2000，108，7： | 1 |
| 10 | Cofilin 1 is revealed as an inhibitor of glucocorticoid receptor by analysis of hormone- resistant cells显示文摘 | Ruegg J Holsboer F Turck C | 2004 | Mol Cell Biol2004，24，： | 1 |
| 11 | Staurosporine, K-252 and UCN-01 : potent but nonspecific inhibitors of protein kinases 显示文摘 | Ruegg U T Burgess G M | 1989 | Trends Pharmacol1989，10，： | 1 |
| 12 | Herbicide research and de- velopment :challenges and opportunities显示文摘 | Ruegg W T Quadranti M Zoschke A | 2007 | Weed Research2007，47，： | 1 |
| 13 | Complete and long-lasting re- gression of disseminated multiple skin melanoma metastases under treatment with eyelooxygenase-2 inhibitor 显示文摘 | Lejeune FJ Monnier Y Ruegg C | 2006 | Melanoma Res2006，16，： | 1 |
| 14 | Meas- urement of ionospheric faraday rotation in simulated and re- al spaceborne SAR data显示文摘 | JEHLE M RUEGG M ZUBERBUHLER L | 2009 | IEEE Transactions on Geosci- ence and Remote Sensing2009，47，5： | 1 |
| 15 | Evaluation of a cyclophilin inhibitor in hepatitis C virus-infected chimeric mice in vivo显示文摘 | Inoue K Umehara T Ruegg UT | 2007 | Hepatology2007，45，4： | 1 |
| 16 | Synthesis of ubichinon-45 and ubichinon-50 显示文摘 | RUEGG R GLOOR U N | 1959 | Helv Chim Acta1959，42，7： | 1 |
| 17 | Capabilities of dual-frequency millimeter wave SAR with monopulse processing for ground moving target indication 显示文摘 | Ruegg M Meier E Nuesch D | 2007 | IEEE Transactions on Geoscience and Remote Sensing2007，45，3： | 1 |
| 18 | Evidence for the involvement of endothelial cell integrin αvβ3 in the disruption of the tumor vasculature induced by TNF and IFN-γ显示文摘 | Ruegg C Yimaz A Bieler G | 1998 | Nat Med1998，4，： | 1 |
| 19 | Recombinant human tumor necrosis factor: an efficient agent for cancer treatment 显示文摘 | LEJEUNE FJ RuEGG C | 2006 | Bull Cancer2006，93，8： | 1 |
| 20 | Active caspase-1 is a regulator of unconventional protein secretion显示文摘 | Keller M Ruegg A Werner S | | 0，，05： | 1 |
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