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| 1 | Metabolomic and elemental profiling of blood serum in bladder cancer显示文摘Bladder cancer(BC)is one of the most frequently diagnosed types of urinary cancer.Despite advances in treatment methods,no specific biomarkers are currently in use.Targeted and untargeted profiling of metabolites and elements of human blood serum from 100 BC patients and the same number of normal controls(NCs),with external validation,was attempted using three analytical methods,i.e.,nuclear magnetic resonance,gold and silver-109 nanoparticle-based laser desorption/ionization mass spectrometry(LDI-MS),and inductively coupled plasma optical emission spectrometry(ICP-OES).All results were subjected to multivariate statistical analysis.Four potential serum biomarkers of BC,namely,isobutyrate,pyroglutamate,choline,and acetate,were quantified with proton nuclear magnetic resonance,which had excellent predictive ability as judged by the area under the curve(AUC)value of 0.999.Two elements,Li and Fe,were also found to distinguish between cancer and control samples,as judged from ICP-OES data and AUC of 0.807(in validation set).Twenty-five putatively identified compounds,mostly related to glycans and lipids,differentiated BC from NCs,as detected using LDI-MS.Five serum metabolites were found to discriminate between tumor grades and nine metabolites between tumor stages.The results from three different analytical platforms demonstrate that the identified distinct serum metabolites and metal elements have potential to be used for noninvasive detection,staging,and grading of BC. | Krzysztof Ossolinski Tomasz Ruman Valerie Copie Brian P.Tripet Leonardo B.Nogueira Katiane O.P.C.Nogueira Artur Kołodziej Aneta Płaza-Altamer Anna Ossolinska Tadeusz Ossolinski Joanna Nizioł | 2022 | Journal of Pharmaceutical Analysis2022，12，6： | 2 |
| 2 | Natural cycle cryothaw transfer may improve pregnancy outcome显示文摘 | Morozov V Ruman J Kenigsberg D | 2007 | J Assist Reprod Genet2007，24，4： | 1 |
| 3 | Natural cycle cryo - thaw transfer may improve pregnancy outcome显示文摘 | Morozov V Ruman J Kenigsberg D | 2007 | J Assist Reprod Genet2007，24，4： | 1 |
| 4 | A Generalized Dou- ble Diamond Approach to the Global Competitiveness of Korea and Singapore显示文摘 | MOON H C RUMAN A M VERBEKE A | 1998 | Intemational Business Review1998，7，2： | 1 |
| 5 | Natural cycle cryo-thaw transfer may improve pregnancy outcome显示文摘 | Morozov V Ruman J Kenigsberg D | | 0，，： | 1 |
| 6 | Protected Geographical Indication Identification of a Chinese Green Tea (Anji-White) by Near-Infrared Spectroscopy and Chemometric Class Modeling Techniques显示文摘 | Lu Xu Peng-Tao Shi Xian-Shu Fu Hai-Feng Cui Zi-Hong Ye Chen-Bo Cai Xiao-Ping Yu Tomasz Ruman | 2012 | Journal of Spectroscopy2012，，： | 1 |
| 7 | The role of peripheral gonadotropin releasing hormone receptors in female reproduction 显示文摘 | Yu B Ruman J Christman G | 2011 | Fertil Ster- il2011，95，2： | 1 |
| 8 | Scratch and mar resistance of filled polypropylene materials 显示文摘 | Chu J Ruman L | 1998 | Polym Eng Sci1998，38，11： | 1 |
| 9 | Antiangiogenic Therapy and Mechanisms of Tumor Resistance in Malignant Glioma显示文摘 | Ruman Rahman Stuart Smith Cheryl Rahman Richard Grundy Arkadiusz Dudek | 2010 | Journal of Oncology2010，，： | 1 |
| 10 | The aromaticity of 5,6-dihydroborauracil, borauracil and benzoborauracil systems显示文摘 | Tomasz Ruman Adam Jarmu Wojciech Rode | 2010 | Bio Chem2010，38，： | 1 |
| 11 | Robust speed control of dc servomotors using modern two degrees-of-freedom controller design显示文摘 | RUMAN T HORI Y | 1991 | IEEE Transactions on Industry Electronics1991，38，5： | 1 |
| 12 | The role of peripheral gonadotropin-releasing hormone receptors in female reproduction显示文摘 | Yu B Ruman J Christman G | 2011 | Fertil Steril2011，95，： | 1 |
| 13 | The aromaticity of 5,6-dihydroborauracil,borauracil and benzoborauracil systems显示文摘 | Tomasz Ruman Adam Jarmua Wojciech Rode | 2010 | Bio Chem2010，38，5： | 1 |
| 14 | A novel mutation of HOXA13 in a family with hand-foot-genital syndrome and the role of polyalanine expansions in the spectrum of Müllerian fusion anomalies显示文摘 | JORGENSEN EM RUMAN JI DOHERTY L | 2010 | Fertil Steril2010，94，4： | 1 |
| 15 | The application of HPLC techniques to the analysis of fuels and oils显示文摘 | Jorikova L Ruman J Davidova M | 2000 | Pet Coal2000，42，： | 1 |
| 16 | The role of peripheral gonadotropin-releasing hormone receptors in female repro- duction显示文摘 | Y u B Ruman J Christman G | 2011 | Fertil Steril2011，95，2： | 1 |
| 17 | Natural cycle cryothaw transfer may improve pregnancy outcome显示文摘 | Mozozov V Ruman J kenigsberg D | 2007 | J Assist Reprod Genet2007，24，： | 1 |
| 18 | Natural cyclecryo-thaw transfer may improve pregnancy outcome显示文摘 | Morozov V Ruman J Kenigsberg D | 2007 | Assist Reprod Genet2007，24，4： | 1 |
| 19 | Natural cycle cryothaw transfer may improve pregnancy outcome 显示文摘 | Morozov V Ruman J Kenigsberg D | 2007 | J Assist Reprod Genet2007，24，4： | 1 |
| 20 | Basic research and clinical progress of sepsis-associated encephalopathy显示文摘Sepsis-associated encephalopathy(SAE),a major cerebral complication of sepsis,occurs in 70%of patients admitted to the intensive care unit(ICU).This condition can cause serious impairment of consciousness and is associated with a high mortality rate.Thus far,several experimental screenings and radiological techniques(e.g.,electroencephalography)have been used for the non-invasive assessment of the structure and function of the brain in patients with SAE.Nevertheless,the pathogenesis of SAE is complicated and remains unclear.In the present article,we reviewed the currently available literature on the epidemiology,clinical manifestations,pathology,diagnosis,and management of SAE.However,currently,there is no ideal pharmacological treatment for SAE.Treatment targeting mitochondrial dysfunction may be useful in the management of SAE. | Ying Huang Ruman Chen Lai Jiang Siyuan Li Yuchen Xue | 2021 | Journal of Intensive Medicine2021，1，2： | 1 |
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