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| 1 | Retinal tissue hypoperfusion in patients with clinical Alzheimer’s disease显示文摘Background:It remains unknow whether retinal tissue perfusion occurs in patients with Alzheimer’s disease.The goal was to determine retinal tissue perfusion in patients with clinical Alzheimer’s disease(CAD).Methods:Twenty-four CAD patients and 19 cognitively normal(CN)age-matched controls were recruited.A retinal function imager(RFI,Optical Imaging Ltd.,Rehovot,Israel)was used to measure the retinal blood flow supplying the macular area of a diameter of 2.5 mm centered on the fovea.Blood flow volumes of arterioles(entering the macular region)and venules(exiting the macular region)of the supplied area were calculated.Macular blood flow was calculated as the average of arteriolar and venular flow volumes.Custom ultra-high-resolution optical coherence tomography(UHR–OCT)was used to calculate macular tissue volume.Automated segmentation software(Orion,Voxeleron LLC,Pleasanton,CA)was used to segment six intra-retinal layers in the 2.5 mm(diameter)area centered on the fovea.The inner retina(containing vessel network),including retinal nerve fiber layer(RNFL),ganglion cell-inner plexiform layer(GCIPL),inner nuclear layer(INL)and outer plexiform layer(OPL),was segmented and tissue volume was calculated.Perfusion was calculated as the flow divided by the tissue volume.Results:The tissue perfusion in CAD patients was 2.58±0.79 nl/s/mm^(3)(mean±standard deviation)and was significantly lower than in CN subjects(3.62±0.44 nl/s/mm^(3),P<0.01),reflecting a decrease of 29%.The flow volume was 2.82±0.92 nl/s in CAD patients,which was 31%lower than in CN subjects(4.09±0.46 nl/s,P<0.01).GCIPL tissue volume was 0.47±0.04 mm^(3) in CAD patients and 6%lower than CN subjects(0.50±0.05 mm^(3),P<0.05).No other significant alterations were found in the intra-retinal layers between CAD and CN participants.Conclusions:This study is the first to show decreased retinal tissue perfusion that may be indicative of diminished tissue metabolic activity in patients with clinical Alzheimer’s disease. | Giovana Rosa Gameiro Hong Jiang Yi Liu Yuqing Deng Xiaoyan Sun Bernardo Nascentes Bernard Baumel Tatjana Rundek Jianhua Wang | 2018 | Eye and Vision2018，5，1： | 2 |
| 2 | 国际卒中遗传学联盟的推荐意见(第2部分):生物样本的采集和储存显示文摘在2003年人类基因组测序以及全基因组基因分型技术发展的共同促进下,人类遗传学的进步已使我们识别出2000多个与性状相关的基因突变。由于这些突变大多数对疾病风险仅有微小的独立影响,因此成功的遗传学研究需要很大的样本量(包含数以千计、万计或者十万计的病例和对照)才能达到足够的研究效能。如此大的样本量积累需要依赖在人类遗传学研究乃至在临床研究中史无前例的大规模国际协作。现在已有许多常见疾病的专病联盟将大量独立机构和合作者联合起来。每个联盟均面临至少2个基本问题:如何整合具有足够数量、同质性和表型质量高的研究样本以及如何储存和分析来自入组受试者的生物样本,有时可能需要在数年间反复进行。 | Thomas W.K.Battey Valerie Valant Sylvia Baedorf Kassis Christina Kourkoulis Chaeyoung Lee Christopher D. Anderson Guido J. Falcone Jordi Jimenez-Conde Israel Fernandez-Cadenas Guillaume Pare Tatjana Rundek Michael L. James Robin Lemmens Tsong-Hai Lee Turgut Tatlisumak Steven J. Kittner Arne Lindgren Farrah J. Mateen Aaron L. Berkowitz Elizabeth G. Holliday Jennifer Majersik 李海峰 姜平 岳耀先 | 2015 | 国际脑血管病杂志2015，23，9： | 2 |
| 3 | Periodontal microbiota and carotid intima-media thickness:the oral infections and vascular disease epidemiology study (INVEST)显示文摘 | Dasvarieux M Demmer RT Rundek T | 2005 | Circulation2005，111，5： | 1 |
| 4 | Carotid plaque, a subclinical precursor of vascular events: the Northern Manhattan Study显示文摘 | Rundek T Arif H Boden-Albala B | 2008 | Neurology2008，70，： | 1 |
| 5 | Carotid plaque a subclinical precusor of vascular events:the Northern Manhattan Study显示文摘 | Rundek T Arif H Boden-Albala B | 2008 | Neurology2008，70，1： | 1 |
| 6 | Interleukin-f is associated with cognitive function: the Northern Manhattan Study 显示文摘 | Wright CB Sacco RL Rundek T | 2006 | J Stroke Cerebrovasc Dis2006，，： | 1 |
| 7 | Traditional risk factors are not major contributors to the variance in carotid intima-media thick- ness显示文摘 | Rundek T Blanton SH Bartels S | 2013 | Stroke2013，44，8： | 1 |
| 8 | Genetic linkage of serum homocysteine in Dominican :!amilies: the family study of stroke risk and carotid atherosclerosis显示文摘 | Della-Morte D Beecham A Rundek T | 2010 | Stroke2010，41，7： | 1 |
| 9 | Alcohol intake, carotid plaque, and cognition : the Northern Manhattan Study 显示文摘 | Wright CB Elkind MS Rundek T | 2006 | Stroke2006，37，5： | 1 |
| 10 | Arotid plaque, a subulinical precursor of vascular events The Northern Manhattan Study 显示文摘 | Rundek J Arif H Boden - Albala B | 2005 | Neurology2005，70，： | 1 |
| 11 | Relationship between periodontal disease, tooth loss, and carotid artery plaque:the Oral infections and Vascular Disease Epidemiology Study ( INVEST ) 显示文摘 | Desvarieux M Demmer R Rundek T | 2003 | Stroke2003，34，9： | 1 |
| 12 | Patent foramen ovale size and embolic brain imaging findings among patients with isehemic stroke显示文摘 | Steiner MM Di Tullio MR Rundek T | 1998 | Stroke1998，29，5： | 1 |
| 13 | Traditional risk factors are not major contributors to the variance in carotid intima-media thickness显示文摘 | Rundek T Blanton SH Bartels S | 2013 | Stroke2013，44，8： | 1 |
| 14 | Carotid intima-media thickness is associated with allelic variants of stromelysin-1,interleukin-6,and hepatic lipase genes-The Northern Manhattan Prospective Cohort Study显示文摘 | Rundek T Elkind MS Pittman J | 2002 | Stroke2002，33，5： | 1 |
| 15 | Relationship between periodontal disease,tooth loss,and carotid artery plaque:the Oral Infections and Vascular Disease Epidemiology Study (INVEST)显示文摘 | Desvarieux M Demmer RT Rundek T | 2003 | Stroke2003，34，9： | 1 |
| 16 | Carotid plaque suface irregularity predicts isehemic stroke:the nortthem Manhattan study 显示文摘 | Prabhakaran S Rundek T Ramas R | 2006 | Stroke2006，37，： | 1 |
| 17 | Cerebrovascular reactivity and vasospasm after subarachnoid hemorrhage:a pilot study 显示文摘 | Frontera JA Rundek T Schmidt JM | 2006 | Neu- rology2006，66，5： | 1 |
| 18 | The relationship between periodontal disease,tooth loss,and carotid artery plaque:the Oral Infections and Vasular Disease Eepidmiology Study(INCEST)显示文摘 | Desvarieux M Demmer RT Rundek T | | 0，，： | 1 |
| 19 | Carotid plaque, a subclinical precursor of vascular events: The Northern Manhattan Study显示文摘 | T Rundek H Arif B Boden-Albala M S. Elkind M C. Paik R L. Sacco | 2008 | Neurology2008，，14： | 1 |
| 20 | Carotid vascular abnormalities in primary hyperparathyroidism显示文摘 | Walker MD Fleischer J Rundek T | 2009 | J Clin Endocrinol Metab2009，94，10： | 1 |
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