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| 1 | Influence of different second generation antipsychotics on the QTc interval: A pragmatic study显示文摘AIM To investigate whether differential influence on the QTc interval exists among four second generation antipsychotics(SGAs) in psychosis.METHODS Data were drawn from a pragmatic, randomized headto-head trial of the SGAs risperidone, olanzapine, quetiapine, and ziprasidone in acute admissions patients with psychosis, and with follow-up visits at discharge or maximally 6-9 wk, 3, 6, 12 and 24 mo. Electrocardiograms were recorded on all visits. To mimic clinical shared decision-making, the patients were randomized not to a single drug, but to a sequenceof the SGAs under investigation. The first drug in the sequence defined the randomization group, but the patient and/or clinician could choose an SGA later in the sequence if prior negative experiences with the first one(s) in the sequence had occurred. The study focuses on the time of, and actual use of the SGAs under investigation, that is until treatment discontinuation or change, in order to capture the direct medication effects on the QTc interval. Secondary intention-to-treat(ITT) analyses were also performed. RESULTS A total of 173 patients, with even distribution among the treatment groups, underwent ECG assessments. About 70% were males and 43% had never used antipsychotic drugs before the study. The mean antipsychotic doses in milligrams per day with standard deviations(SD) were 3.4(1.2) for risperidone, 13.9(4.6) for olanzapine, 325.9(185.8) for quetiapine, and 97.2(42.8) for ziprasidone treated groups. The time until discontinuation of the antipsychotic drug used did not differ in a statistically significant way among the groups(Log-Rank test: P = 0.171). The maximum QTc interval recorded during follow-up was 462 ms. Based on linear mixed effects analyses, the QTc interval change per day with standard error was-0.0030(0.0280) for risperidone;-0.0099(0.0108) for olanzapine;-0.0027(0.0170) for quetiapine, and-0.0081(0.0229) for ziprasidone. There were no statistically significant differences among the groups in this regard. LME analyses based on ITT groups(the randomization groups), revealed almost identical slopes with-0.0063(0.0160) for risperidone,-0.0130(0.0126) for olanzapine,-0.0034(0.0168) for quetiapine, and-0.0045(0.0225) for ziprasidone. CONCLUSION None of the SGAs under investigation led to statistically significant QTc prolongation. No statistically significant differences among the SGAs were found. | Roy E Olsen Rune A Kroken Sigmund Bj?rhovde Kristina Aanesen Hugo A J?rgensen Else-Marie L?berg Erik Johnsen | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 2 | Vitamin D receptor: a new risk marker for clinical restenosis after percutaneous coronary intervention显示文摘 | Pascalle S Monraats Yue Fang Douwe Pons Nuno MM Pires Huibert AP Pols Aeilko H Zwinderman Moniek PM de Maat Pieter AF Doevendans Robbert J deWinter René A Tio Johannes Waltenberger Rune R Frants Paul HA Quax Arnoud van der Laarse Ernst E van der Wall Andr | 2010 | Expert Opinion on Therapeutic Targets2010，，： | 1 |
| 3 | In-situ electrochemical atomic force microscopy studies of aqueous corrosion and inhibition of copper 显示文摘 | BERTRAND G ROCCA E SAVALL C RAPIN C LAB RUNE J C STEINMETZ P | 2000 | Journal of Electroanalytical Chemistry2000，489，12： | 1 |
| 4 | How much do road accident cost the national economy? 显示文摘 | Rune E | 2000 | Accident Analysis and Prevention2000，32，： | 1 |
| 5 | Gene expression regulation by retinoic acid 显示文摘 | James E Rune IB | 2002 | J Lipid Res2002，43，11： | 1 |
| 6 | Qualitative and quantitative liquid chromatographic determination of natural retinoids in biological samples显示文摘 | Thomas E Gundersen Rune Blomhoff | 2001 | Journal of Chromatography A2001，935，： | 1 |
| 7 | Qualitative and quantitative liquid chromatographic determination of natural retinoids in biological samples显示文摘 | Thomas E Gundersen Rune Blomhoff | 2001 | Journal of Chromatography A2001，935，： | 1 |
| 8 | A continental phenology model for monitoring vegetation responses to interannual climatic variability显示文摘 | White M A Thornton P E Runing S W | 1997 | Global Biogeochemical Cycles1997，11，2： | 1 |
| 9 | Adsorption properties and structure of CO2 adsorbed on open coordination sites of metal-or- ganic framework Ni2(dhtp) from gas adsorption, lR spectrosco- py and X-ray diffraction 显示文摘 | Pascal D C D Rune E J Helmet F | 2008 | Chemical Communications2008，，： | 1 |
| 10 | How Would Setting Policy Priorities According to Cost - benefit Analyses Affect the Provision of Road Safety 显示文摘 | Rune E | 2002 | Accident Analysis & Prevention2002，，868： | 1 |
| 11 | Qualitative and quantitative liquid c-hromatographic determination of natural retinoids in biological s-amples显示文摘 | THOMAS E RUNE B | 2001 | Journal of Chromatography A2001，935，1： | 1 |
| 12 | Road Safety Effects of Porous Asphalt:A Systematic Review of Evaluation Studies显示文摘 | Rune E Poul G | 2005 | Accident Analysis and Prevention2005，，37： | 1 |
| 13 | Qualitative and quantitative liquid chromatographic determination of natural retinoids in biological samples显示文摘 | THOMAS E GUNDERSEN RUNE BLOMHOFF | 2001 | Journal of Chromatography A2001，935，： | 1 |
| 14 | Fluorescene imaging studis for the disposition of daunoribicin liposomes( dauno Xome) with tumor tissure显示文摘 | FORSSEN E A MALE RUNE R MOORE J P | 1996 | Cancer Res1996，56，20： | 1 |
| 15 | Area-Wide Urban Traffic Calming Schemes: A Meta- Analysis of Safety Effects 显示文摘 | Rune E | 2001 | Accident Analysis & Prevention2001，33，3： | 1 |
| 16 | Apolipoprotein gene cluster on chromosome 19显示文摘 | Smit M van der Kooij-Meijs E Rune RF | | 0，，： | 1 |
| 17 | Biofilm morphology in porous media, a study with microscopic and image techniques 显示文摘 | PAULSEN J E EIRIK O RUNE B | 1997 | Water Science and Technology1997，36，1： | 1 |
| 18 | 精液特征异常男性罹患睾丸癌风险的队列研究显示文摘目的探讨精液特征与后续睾丸癌发病风险之间的关系。设计队列研究。参与者1963-1995年在哥本哈根精子分析实验室进行精液分析的32442名男性。主要观察指标与丹麦男性总人口的睾丸癌标准化发病率进行比较。 | Rune Jacobsen Erik Bostofte Gerda Engholm Johnni Hansen JФrgen H Olsen Niels E Skakkebek Henrik MФller 秦超(译) 李宏军(校) | 2022 | 英国医学杂志中文版2022，25，7： | 0 |
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