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| 1 | Role of digital chromoendoscopy and confocal laser endomicroscopy for gastric intestinal metaplasia and cancer surveillance显示文摘In Japan and countries such as South Korea and Tai-wan, China, the standard technique for detecting earlygastric cancer (EGC) is chromoendoscopy. This technique involves a magnified endoscope and the use ofan indigo-carmine spray to distinguish between EGCand non-EGC areas. However, this technique is notwidely adopted in many parts of the world. One important reason for limited use is that this technique needsan experienced endoscopist to interpret the imagesduring the procedure. In addition, the sensitivity for detecting gastric intestinal metaplasia (GIM), a precancerous lesion of EGC, is graded as suboptimal. Moreover,the requirement of a cumbersome spraying method isinconvenient and needs preparation time. Easier digitalchromoendoscopy techniques, such as Narrow-bandImaging and Flexible spectral Imaging Color Enhancement, have been reported to facilitate targeted GIM and EGC biopsy. They provide higher sensitivities over conventional white light endoscopy. Recently, the noveltechnology of confocal laser endomicroscopy has been introduced as a high-magnification (1000 ×) real-time evaluation for many early gastrointestinal (GI) cancersand precancerous GI lesions, including colonic polyp,Barrett's esophagus, and GIM. The advantage of this technique is that it can be used as an in vivo confirmation of the presence of GIM and EGC during endoscopic surveillance. This review aims to explain the current information on the usefulness of digital chromoendos-copy and confocal laser endomicroscopy for evaluating GIM and EGC during endoscopic surveillance and the possible future role of these techniques for GI cancerscreening programs. | Rapat Pittayanon Rungsun Rerknimitr | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，10： | 15 |
| 2 | Diagnostic role of serum interleukin-18 in gastric cancer patients显示文摘瞄准:在胃的癌症病人的各种各样的方面决定当前的地位并且在泰国病人与浆液 interleukins 的预示的角色发现临床的关联。方法:68 个病人在 2003 年 4 月期间在楚拉隆克恩国王纪念物医院在这研究被注册到 2005 年 5 月。胃的癌症组织学地在 17 个病人在 51 个病人和胃溃疡被证明。浆液 IL-6, IL-10, IL-12,和 IL-18 层次被连接酶的免疫吸着剂试金(ELISA ) 测量。结果:有 26 男性(55.32%) 和 21 女性(44.68%) ,他们的年龄从 33 ~ 85 年(意味着年龄 64.49 +/- 13.83 年) 。普通演讲是重量损失(41.2%) ,消化不良(39.2%) ,并且上面的胃肠的流血 15.7%) 。35.3% 胃的癌症病人的一个总数并且 6.3% 胃溃疡病人是吸烟者(P = 0.029 ) 。而且, 32.4% 胃的癌症病人和 6.3% 胃溃疡病人是含酒精的喝酒者(P = 0.044 ) 。损害地点在 39.4% 是幽门窦的,在 39.4% 的胃的身体,在 12.2% 的上面的胃和在 6.1% 病人的全部胃。H pylori 感染在 44.4% 被检测。糟糕区分的腺癌是最普通的病理学的发现(60.7%) 。外科疗法在 44.1% 病人被执行(在 5.9% 的全胃切除术,在 32.4% 的大部胃切除术和 palliative 在 5.9% 绕过外科) 。全身的化疗在 8.8% 病人作为辅助治疗被给。癌病 peritoneii 在 18.8% 病人被发现。吝啬的生存时间是 13.03 +/- 9.75 瞬间。在胃的癌症病人组的 IL-18 水平(58.54 +/- 43.96 pg/mL ) 在胃溃疡病人组比那显著地高(30.84 +/- 11.18 pg/mL )(P = 0.0001 )(95% CI 是 42.20, 13.19 ) 。为胃的癌症的诊断的 IL-18 的伤口点是 40 pg/mL,积极预兆的价值是 92.31% 。在有远转移的胃的癌症病人的 IL-6 水平(20.21 +/- 9.37 pg/mL ) 在没有转移的那些比那显著地高(10.13 +/- 7.83 pg/mL )(P = 0.037 )(95% CI 是 19.51, 0.65 ) 。在胃的癌症病人的 IL-10 和 IL-12 层次的角色是没有有效差量提供数据。结论:这些调查结果表明那浆液 IL-6 和 IL-18,然而并非 IL-10 和 IL-12 层次可以在有胃的癌症的病人是临床的关联和预示的因素的有用生物标记。而且, IL-18 能与高积极的预兆的价值为胃的癌症用作一个诊断标记。 | Duangporn Thong-Ngam Pisit Tangkijvanich Rungsun Lerknimitr Varocha Mahachai Apiradee Theamboonlers Yong Poovorawan | 2006 | World Journal of Gastroenterology2006，12，28： | 13 |
| 3 | Efficacy of leukocyte esterase dipstick test as a rapid test in diagnosis of spontaneous bacterial peritonitis显示文摘AIM: To evaluate the efficacy of dipstick test in diagnosis of spontaneous bacterial peritonitis (SBP) in cirrhotic patients who underwent abdominal paracentesis based on the locally available dipstick test. METHODS: There were 200 consecutive samples from cirrhotic patients who underwent abdominal paracentesis. Urine dipstick (Combur10 Test?M, Roche, Mannheim, Germany) was used as a screening test. A manual cell count with differential study was done in all samples by experienced technicians. The polymorphonuclear (PMN) cell count more than 250 cells/mm3 was used as a diagnostic cut off level. One to three plus dipstick results were used as cut off levels for a positive result. The dipstick test results had to be agreed by three experienced readers. The sensitivity, specificity, positive and negative predictive values and accuracy of two different colorimetric cut off scales (1+ and 2+) were calculated and compared. RESULTS: The prevalence of SBP diagnosed by manual cell count was 21.0%. There were 128 specimens that had a true negative result by dipstick. The sensitivity, specificity, positive and negative predictive values and accuracy of 1+ and 2+ cut off scale to diagnose SBP were 88%, 81%, 55%, 96% and 83% respectively, and 63%, 96%, 82%, 81% and 89% respectively. CONCLUSION: Dipstick test can be used as a rapid test for screening of SBP. The higher cut off colorimetric scale has a better specificity and positive predictive value but a lower sensitivity. | Rungsun Rerknimitr Worawut Rungsangmanoon Pradermchai Kongkam Pinit Kullavanijaya | 2006 | World Journal of Gastroenterology2006，12，44： | 8 |
| 4 | Per oral cholangiopancreatoscopy in pancreatico biliary diseases- Expert consensus statements显示文摘AIM: To provide consensus statements on the use of per-oral cholangiopancreatoscopy(POCPS).METHODS: A workgroup of experts in endoscopic retrograde cholangiopancreatography(ERCP), endosonography, and POCPS generated consensus statements summarizing the utility of POCPS in pancreaticobiliary disease. Recommendation grades used validated evidence ratings of publications from an extensive literature review.RESULTS: Six consensus statements were generated:(1) POCPS is now an important additional tool during ERCP;(2) in patients with indeterminate biliary strictures, POCS and POCS-guided targeted biopsy are useful for establishing a definitive diagnosis;(3) POCS and POCS-guided lithotripsy are recommended for treatment of difficult common bile duct stones when standard techniques fail;(4) in patients with main duct intraductal papillary mucinous neoplasms(IPMN) POPS may be used to assess extent of tumor to assist surgicalresection;(5) in difficult pancreatic ductal stones,POPS-guided lithotripsy may be useful in fragmentation and extraction of stones; and(6) additional indications for POCPS include selective guidewire placement,unexplained hemobilia, assessing intraductal biliary ablation therapy, and extracting migrated stents. CONCLUSION: POCPS is important in association with ERCP, particularly for diagnosis of indeterminate biliary strictures and for intra-ductal lithotripsy when other techniques failed, and may be useful for preoperative assessment of extent of main duct IPMN, for extraction of difficult pancreatic stones, and for unusua indications involving selective guidewire placement,assessing unexplained hemobilia or intraductal biliary ablation therapy, and extracting migrated stents. | Mohan Ramchandani Duvvur Nageshwar Reddy Sundeep Lakhtakia Manu Tandan Amit Maydeo Thoguluva Seshadri Chandrashekhar Ajay Kumar Randhir Sud Rungsun Rerknimitr Dadang Makmun Christopher Khor | 2015 | World Journal of Gastroenterology2015，21，15： | 8 |
| 5 | Non-sequential narrow band imaging for targeted biopsy and monitoring of gastric intestinal metaplasia显示文摘AIM: To evaluate the efficacy of non-sequential narrow band imaging (NBI) for a better recognition of gastric intestinal metaplasia (GIM). METHODS: Previously diagnosed GIM patients underwent targeted biopsy from areas with and without GIM, as indicated by NBI, twice at an interval of 1 year. The authors compared the endoscopic criteria such as light blue crest (LBC), villous pattern (VP), and large long crest (LLC) with standard histology. The results from two surveillance endoscopies were compared with histology results for sensitivity, specif icity, positive predic-tive value (PPV), negative predictive value (NPV), and likelihood ratio of positive test (LR+). The number of early gastric cancer cases detected was also reported. RESULTS: NBI targeted biopsy was performed in 38 and 26 patients during the first and second surveillance endoscopies, respectively. There were 2 early gastric cancers detected in the first endoscopy. No cancer was detected from the second study. Surgical and endoscopic resections were successfully performed in each patient. Sensitivity, specifi city, PPV, NPV, and LR+ of all 3 endoscopic criteria during the first/second surveillances were 78.8%/91.3%, 82.5%/89.1%, 72.8%/77.8%, 86.8%/96.1, and 4.51/8.4, respectively. LBC provided the highest LR+ over VP and LLC. CONCLUSION: Non-sequential NBI is useful for GIM targeted biopsy. LBC provides the most sensitive reading. However, the optimal duration between two surveillances requires further study. | Rungsun Rerknimitr Boonlert Imraporn Naruemon Klaikeaw Wiriyaporn Ridtitid Sukprasert Jutaghokiat Yuwadee Ponauthai Pradermchai Kongkam Pinit Kullavanijaya | 2011 | World Journal of Gastroenterology2011，17，10： | 7 |
| 6 | Infliximab stopped severe gastrointestinal bleeding in Crohn's disease显示文摘To report the result of rapid ulcer healing by infliximab in Crohn's patients with severe enterocolic bleeding. During 2005 and 2010, inflammatory bowel disease database of King Chulalongkorn Memorial and Samitivej hospitals were reviewed. There were seven Crohn's disease (CD) patients (4 women and 3 men; mean age 52 ± 10.4 years; range: 11-86 years). Two of the seven patients developed severe gastrointestinal bleeding (GIB) as a flare up of CD whereas the other five patients presented with GIB as their first symptom for CD. Their mean hemoglobin level dropped from 12 ± 1.3 g/ dL to 8.7 ± 1.3 g/dL in a 3-d period. Median packed red blood cells units needed for resuscitation was 4 units. Because of uncontrolled bleeding, surgical resection was considered. However, due to the poor surgical candidacy of these patients (n = 3) and /or possible development of short bowel syndrome (n = 6), surgery was not pursued. Likewise angiographic embolization was not considered in any due to the risk of large infarction. All severe GIBs successfully stopped by one or two doses of intravenous infliximab. Our data suggests that infliximab is an alternative therapy for CD with severe GIB when surgery has limitation or patient is a high risk. | Satimai Aniwan Surasak Eakpongpaisit Boonlert Imraporn Surachai Amornsawadwatana Rungsun Rerknimitr | 2012 | World Journal of Gastroenterology2012，18，21： | 6 |
| 7 | Bleeding gastric varices: Results of endoscopic injection with cyanoacrylate at King Chulalongkorn Memorial Hospital显示文摘AIM: To evaluate the efficacy and safety of gastric varices injection with cyanoacrylate in patients with gastric variceal bleeding.METHODS: Twenty-four patients (15 males, 9 females) with gastric variceal bleeding underwent endoscopic treatment with cyanoacrylate injection. Successful hemostasis, rebleeding rate, and complications were retrospectively reviewed. Followed up endoscopy was performed and repeat cyanoacrylate injection was given until gastric varices were obliterated. RESULTS: Seventeen patients achieved definite hemostasis. Of these, 14 patients had primary success after initial endoscopic therapy. Ten patients developed recurrent bleeding. Repeated cyanoacrylate injection stopped rebleeding in three patients. Transjugular intrahepatic portosystemic shunt (TIPS) was performed to control rebleeding in one patient which occured after repeat endoscopic therapy. Six patients died (three from uncontrolled bleeding, two from sepsis, and one from mesenteric vein thrombosis). Minor complications occurred in 11 patients (six epigastric discomfort and five post injection ulcers). Cyanoacrylate embolism developed in two patients. One of these patients died from mesenteric vein thrombosis. The other had pulmonary embolism which resolved spontaneously. Advanced cirrhosis and hepatocellular carcinoma (HCC) were major risk factors for uncontrolled bleeding.CONCLUSION: Endoscopic treatment for bleeding gastric varices with cyanoacrylate injection is effective for immediate hemostasis. Repeat cyanoacrylate injection has a lower success rate than the initial injection.Cyanoacrylate embolism is not a common serious complication. | Phadet Noophun Pradermchai Kongkam Sutep Gonlachanvit Rungsun Rerknimitr | 2005 | World Journal of Gastroenterology2005，11，47： | 5 |
| 8 | Forward-viewing radial-array echoendoscope for staging of colon cancer beyond the rectum显示文摘AIM:To evaluate feasibility of the novel forward-viewing radial-array echoendoscope for staging of colon cancer beyond rectum as the first series.METHODS:A retrospective study with prospectively entered database.From March 2012 to February 2013,a total of 21 patients(11 men)(mean age 64.2 years)with colon cancer beyond the rectum were recruited.The novel forward-viewing radial-array echoendoscope was used for ultrasonographic staging of colon cancer beyond rectum.Ultrasonographic T and N staging were recorded when surgical pathology was used as a gold standard.RESULTS:The mean time to reach the lesion and the mean time to complete the procedure were 3.5 and 7.1min,respectively.The echoendoscope passed through the lesions in 13 patients(61.9%)and reached the cecum in 10 of 13 patients(76.9%).No adverse events were found.The lesions were located in the cecum(n=2),ascending colon(n=1),transverse colon(n=2),descending colon(n=2),and sigmoid colon(n=14).The accuracy rate for T1(n=3),T2(n=4),T3(n=13)and T4(n=1)were 100%,60.0%,84.6%and 100%,respectively.The overall accuracy rates for the T and N staging of colon cancer were 81.0%and52.4%,respectively.The accuracy rates among traversable lesions(n=13)and obstructive lesions(n=8)were 61.5%and 100%,respectively.endoscopic ultrasound and computed tomography had overall accuracy rates of 81.0%and 68.4%,respectively.CONCLUSION:The echoendoscope is a feasible staging tool for colon cancer beyond rectum.However,accuracy of the echoendoscope needs to be verified by larger systematic studies. | Pradermchai Kongkam Sittikorn Linlawan Satimai Aniwan Narisorn Lakananurak Suparat Khemnark Chucheep Sahakitrungruang Jirawat Pattanaarun Supakij Khomvilai Naruemon Wisedopas Wiriyaporn Ridtitid Manoop S Bhutani Pinit Kullavanijaya Rungsun Rerknimitr | 2014 | World Journal of Gastroenterology2014，20，10： | 5 |
| 9 | Management of an occluded biliary metallic stent显示文摘In patients with a malignant biliary obstruction who require biliary drainage,a self-expandable metallic stent(SEMS) provides longer patency duration than a plastic stent(PS).Nevertheless,a stent occlusion by tumor ingrowth,tumor overgrowth and biliary sludge may develop.There are several methods to manage occluded SEMS.Endoscopic management is the preferred treatment,whereas percutaneous intervention is an alternative approach.Endoscopic treatment involves mechanical cleaning with a balloon and a second stent insertion as stent-in-stent with either PS or SEMS.Technical feasibility,patient survival and cost-effectiveness are important factors that determine the method of re-drainage and stent selection. | Wiriyaporn Ridtitid Rungsun Rerknimitr | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，5： | 5 |
| 10 | Multicenter randomised controlled trial comparing the high definition white light endoscopy and the bright narrow band imaging for colon polyps显示文摘AIM To compare high definition white light endoscopy and bright narrow band imaging for colon polyps' detection rates. METHODS Patients were randomised to high definition white light endoscopy(HD-WLE) or the bright narrow band imaging(b NBI) during withdrawal of the colonoscope. Polyps identified in either mode were characterised using b NBI with dual focus(b NBI-DF) according to the Sano's classification. The primary outcome was to compare adenoma detection rates(ADRs) between the two arms. The secondary outcome was to assess the negative predictive value(NPV) in differentiating adenomas from hyperplastic polyps for diminutive rectosigmoid lesions.RESULTS A total of 1006 patients were randomised to HD-WLE(n = 511) or b NBI(n = 495). The mean of adenoma per patient was 1.62 and 1.84, respectively. The ADRs in b NBI and HD-WLE group were 37.4% and 39.3%, respectively. When adjusted for withdrawal time(OR = 1.19, 95%CI: 1.15-1.24, P < 0.001), the use of b NBI was associated with a reduced ADR(OR = 0.69, 95%CI: 0.52-0.92). Nine hundred and thirty three polyps(86%) in both arms were predicted with high confidence. The sensitivity(Sn), specificity(Sp), positive predictive value and NPV in differentiating adenomatous from non-adenomatous polyps of all sizes were 95.9%, 87.2%, 94.0% and 91.1% respectively. The NPV in differentiating an adenoma from hyperplastic polyp using b NBI-DF for diminutive rectal polyps was 91.0%.CONCLUSION ADRs did not differ between b NBI and HD-WLE, however HD-WLE had higher ADR after adjustment of withdrawal time. b NBI surpassed the PIVI threshold for diminutive polyps. | Rajvinder Singh Kuan Loong Cheong Leonardo Zorron Cheng Tao Pu Dileep Mangira Doreen Siew Ching Koay Carmen Kee Siew Chien Ng Rungsun Rerknimitr Satimai Aniwan Tiing-Leong Ang Khean-Lee Goh Shiaw Hooi Ho James Yun-Wong Lau | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，6： | 2 |
| 11 | Biliary tract complications after orthotopic liver transplantation with choledochocholedochostomy anastomosis: endoscopic findings and results of therapy显示文摘 | Rungsun Rerknimitr Stuart Sherman Evan L. Fogel Cem Kalayci Lawrence Lumeng Naga Chalasani Paul Kwo Glen A. Lehman | 2002 | Gastrointestinal Endoscopy2002，，2： | 2 |
| 12 | Role of digital chromoendoscopy in detecting minimal change esophageal reflux disease显示文摘Endoscopy is a widely used diagnostic tool to detect reflux esophagitis.Although its specificity was reported to be excellent at 90%-95%,its sensitivity was only 50%.Therefore,it is quite difficult to detect these lesions under the standard white light endoscopy especially in patients with minimal change esophageal reflux disease(MERD).In recent years,endoscopic technologies have evolved tremendously;these include high resolution and magnification digital chromoendoscopy.These technologies are useful practically for detecting various subtle lesions along the gastrointestinal tract starting from esophagus to colon.Currently,these technologies can be classified in 2 systems;pre-processed system(NBI,Olympus)and post processed system(FICE and i-SCAN,Fujinon and Pentax respectively).Over a few years,there have been many emerging publications on the benefit of these systems on MERD detection.The overall sensitivities to diagnose MERD were reported as much better than controls.However,large,multi-center and randomized controlled studies comparing these new imaging modalities with the conventional white light chromoendoscopy are warranted to validate its accuracy.Standard,simple and precise endoscopic reading criteria for the identification of MERD are also required. | Roongruedee Chaiteerakij Rungsun Rerknimitr Pinit Kullavanijaya | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，4： | 2 |
| 13 | Advances in diagnostic endoscopy for duodenal, including ampullary, adenoma显示文摘 | Rapat Pittayanon Boonlert Imraporn Rungsun Rerknimitr Pinit Kullavanijaya | 2014 | Digestive Endoscopy2014，，： | 2 |
| 14 | Prediction of fluid responsiveness in septic shock patients: comparing stroke volume variation by FloTrac/Vigileo and automated pulse pressure variation显示文摘 | Bodin Khwannimit Rungsun Bhurayanontachai | 2012 | European Journal of Anaesthesiology2012，，2： | 2 |
| 15 | Result of endoscopic biliary drainage in hilar cholangiocarcinoma显示文摘 | Rerknimitr Rungsun K ladcharoen | 2004 | J Clia Gastroenterol2004，38，6： | 1 |
| 16 | Prediction of fluid responsiveness in septic shock patients: comparing stroke volume variation by FloTrac/Vigileo and automated pulse pressure variation显示文摘 | Bodin Khwannimit Rungsun Bhurayanontachai | 2012 | European Journal of Anaesthesiology2012，，2： | 1 |
| 17 | Differences in characteristics of colorectal neoplasm between young and elderly Thais显示文摘AIM: To analyze the differences of clinical characteristics of colorectal neoplasm including polyps between the elderly and young Thai patients.METHODS: Colonoscopy database from December 2000 to October 2004 was retrospectively analyzed. There were 1822 eligible patients who underwent colonoscopy (with a mean age of 56.6 years). Patients were classified into two groups: the older age group (aged ≥ 60 years; n = 989) and the younger age group (aged < 60 years; n = 833). Data were recorded on age, colonoscopic indications, tumor location, colonoscopic findings and their related histological findings. RESULTS: Colorectal malignancy related lesions were more often found in the older age group (21%) than in the younger age group (12%). Left-sided lesions were detected more commonly than right-sided in both age groups in approximately two-thirds of all cases. Hematochezia showed greater association with left-sided lesions in the elderly. No relationship was found between age and neoplasm staging and severity.CONCLUSION: The chance of detecting colorectal neoplasm by colonoscopy was higher in the elderly than in the young Thais. However, both groups had the lesions predominantly located in the left side. | Rungsun Rerknimitr Winudda Ratanapanich Pradermchai Kongkam Pinit Kullavanijaya | 2006 | World Journal of Gastroenterology2006，12，47： | 1 |
| 18 | A decision support system for integrating land use,transport and environmental planning in developing metropolises显示文摘 | Kazuaki Miyamoto Rungsun Udomsri Sathindra Sathyaprasad | 1996 | Computers Environment and Urban Systems1996，20，45： | 1 |
| 19 | A sia– P acific consensus recommendations for endoscopic and interventional management of hilar cholangiocarcinoma显示文摘 | Rungsun Rerknimitr Phonthep Angsuwatcharakon Thawee Ratanachu‐ek Christopher J L Khor Ryan Ponnudurai Jong Ho Moon Dong Wan Seo Linda Pantongrag‐Brown Apichat Sangchan Pises Pisespongsa Thawatchai Akaraviputh Nageshwar D Reddy Amit Maydeo Takao Itoi Nonth | 2013 | J Gastroenterol Hepatol2013，，4： | 1 |
| 20 | Result of Endoscopic Biliary Drainage in Hilar Cholangiocarcinoma显示文摘 | Rungsun Rerknimitr Nusont Kladcharoen Varocha Mahachai Pinit Kullavanijaya | 2004 | Journal of Clinical Gastroenterology2004，，6： | 1 |
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