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| 1 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 2 | Heat stress management in underground mines显示文摘Heat management must be maintained within the mine working environment to minimize stress on equipment and personnel. The issue is a growing concern as mines continue to expand in size, depth and infrastructure. Heat management is a concern as it relates to both heat sensitive equipment and more importantly the health and safety of the workers found within the mine. Proper application of engineering protocols and work practice controls will have a direct impact on the health and safety of workers and increased productivity. Using continuous monitoring stations placed in strategic locations throughout the mine to capture the environmental conditions, various strategies can be used in the planning and prevention of potential hazard exposure. Economic analysis is used to select the most feasible strategy for heat stress control. This paper presents a step by step methodology that may be considered by ventilation specialists to effectively implement a heat management control system. A case study based on a detailed heat management assessment conducted for a potash mine in Saskatchewan, Canada is presented. | Ryan Anderson Euler De Souza | 2017 | International Journal of Mining Science and Technology2017，27，4： | 6 |
| 3 | Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A‐RIPK1‐dependent necroptosis显示文摘 | Sahar A. Saddoughi Salih Gencer Yuri K. Peterson Katherine E. Ward Archana Mukhopadhyay Joshua Oaks Jacek Bielawski Zdzislaw M. Szulc Raquela J. Thomas Shanmugam P. Selvam Can E. Senkal Elizabeth Garrett‐Mayer Ryan M. De Palma Dzmitry Fedarovich Angen Liu | 2012 | EMBO Mol Med2012，，1： | 2 |
| 4 | Decoupled control of a four-leg inverter via a new 4 × 4 transformation matrix显示文摘 | Ryan M J De Doncker R W Lorenz R D | 2001 | IEEE Trans on PE2001，16，5： | 1 |
| 5 | Purification and characterization of hepatic microsomal cytochrome P450显示文摘 | Ryan DE Levin W | 1990 | Pharmacolther1990，45，： | 1 |
| 6 | Trends in medical use and abuse of opioid analgesics显示文摘 | Joranson DE Ryan KM Gilson AM | 2000 | JAMA2000，283，17： | 1 |
| 7 | Co translational,in- traribosomal cleavage of polypeptides by the foot-and mouth dis ease virus 2A peptide显示文摘 | De Felipe P Hughes L E Ryan M D | 2003 | J Biol Chem2003，278，11： | 1 |
| 8 | An evaluation of the gamma interferon test for detecting bovine tuberculosis in cattle 8 to 28 days after tuberculosis following skin testing 显示文摘 | Ryan T J Buddle B M de Lisle G M | 2000 | Res Vet Sci2000，69，1： | 1 |
| 9 | Trends in medical use and abuse of opioid analgesics显示文摘 | Joranson DE Ryan KM Gilson AM | 2000 | JAMA2000，283，13： | 1 |
| 10 | Discrete choiceexperiments in health economics:a review of the literature显示文摘 | de Bekker-Grob EW Ryan MtGerard K | 2012 | HealthEcon2012，21，2： | 1 |
| 11 | Relationship of TIMI Myocardial Perfusion Grade to Mortality After Administration of Thrombolytic Drugs显示文摘 | C. Michael Gibson Christopher P. Cannon Sabina A. Murphy Kathryn A. Ryan Rebecca Mesley Susan J. Marble Carolyn H. McCabe Frans Van de Werf Eugene Braunwald | 2000 | Circulation: Journal of the American Heart Association2000，，2： | 1 |
| 12 | Co-translational,intraribosomal cleavage of polypetides by the foot-and-mouth disease virus 2A peptide显示文摘 | De Felipe P Hughes L E Ryan M D | 2003 | J Biol Chem2003，278，11： | 1 |
| 13 | Abiraterone in metastatic prostate cancer without previous chemotherapy 显示文摘 | Ryan C J Smith M R de Bono J S | 2013 | N Engl J Med2013，368，2： | 1 |
| 14 | Trends in medical use and abuse of opioid analgesics显示文摘 | Joranson DE Ryan MK Gilson AM | 2000 | JAMA2000，283，13： | 1 |
| 15 | Trends in medical use and abuse of opioid analgesics显示文摘 | Joranson DE Ryan KM Gilson AM | 2000 | JAMA2000，283，13： | 1 |
| 16 | Decoupled control of a four-leg inverter via a new 4 x4 transformation matrix 显示文摘 | Ryan M J De Doncker R W Lorenz R D | 2001 | IEEE Trans on Power Electronics2001，16，5： | 1 |
| 17 | Decoupled control of a four-leg inverter via a new 4×4 transformation matrix显示文摘 | Ryan M J De Doncker R W Lorenz R D | 2001 | IEEE Trans on PE2001，16，5： | 1 |
| 18 | Trends in medical use and abuse of opioid analgesics显示文摘 | Joranson DE Ryan KM Glison AM | 2000 | JAMA2000，283，13： | 1 |
| 19 | Decoupled control of a four-leg inverter via a new 4 × 4 transformation matrix显示文摘 | RYAN M J de DONCKER R W LORENZ R D | 2001 | IEEE Trans on PE2001，16，5： | 1 |
| 20 | The stressful life events schedule for children and adolescents: Development and validation 显示文摘 | WILLIAMSON DE BIRMAHER B RYAN N D | 2003 | Psychiatry Res2003，119，3： | 1 |
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