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| 1 | Helicobacter pylori-infected animal models are extremely suitable for the investigation of gastric carcinogenesis显示文摘Although various animal models have been developed to clarify gastric carcinogenesis, apparent mechanism of gastric cancer was not clarified in recent years. Since the recognition of the pathogenicity of Helicobacter pylori (Hpylori), several animal models with Hpylori infection have been developed to confirm the association between Hpylori and gastric cancer. Nonhuman primate and rodent models were suitable for this study. Japanese monkey model revealed atrophic gastritis and p53mutation after long-term infection of Hpylori. Mongolian gerbil model showed the development of gastric carcinoma with H pylori infection alone, as well as with combination of chemical carcinogens, such as N-methylN-nitrosourea and N-methyl-N-nitro-N'-nitrosoguanidine.The histopathological changes of these animal models after Hpylori inoculation are closely similar to those in human beings with Hpylori infection. Eradication therapy attenuated the development of gastric cancer in Hpyloriinfected Mongolian gerbil. Although several features of animal models differ from those seen in human beings,these experimental models provide a starting point for further studies to clarify the mechanism of gastric carcinogenesis as a result of Hpylori infection and assist the planning of eradication therapy to prevent gastric carcinoma. | Masaaki Kodama Kazunari Murakami Ryugo Sato Tadayoshi Okimoto Akira Nishizono Toshio Fujioka | 2005 | World Journal of Gastroenterology2005，11，45： | 19 |
| 2 | Expression of mutant type-p53 products in H pylori-associated chronic gastritis显示文摘AIM:To investigate the mutation of p 53 immuno-histochemically in non-tumorous gastric mucosa with H pylori infection before and after H pylori eradication therapy.METHODS:53 subjects(36 male,17 female,mean age ± SEM,57.1 ± 12.1)undergoing endoscopic examination were included in this study.42 of 53 patients were H pylori-positive,and 11 were H pylori-negative.All H pylori-positive patients had successful eradication therapy.Biopsy specimens were taken from five points of the stomach,as recommended by the updated Sydney system.Immunohistochemical studies were performed by using primary antibodies against p53(DO-7 and PAb240).RESULTS:p53(DO-7 and PAb240)immunoreactivity was shown in the neck region of the gastric pits,however,quite a few cells were found to be immunopositive for p 53(PAb240)in the H pylori-infected gastric mucosa.The proportion of patients immunopositive for p 53(PAb240)was significantly reduced 6 mo after eradication [28/42(66.7%)to 6/42(14.3%)](P < 0.05),while the biopsies taken from H pylori-negative patients showed no immunoreactivity for p53(PAb240).p53(PAb240)-positive patients were divided into two groups by the number of positive cells detected:one with more than six positive cells per 10 gastric pits(group A,n = 12),and the other with less than five positive cells per 10 gastric pits(group B,n = 30).Atrophy scores in group A were significant higher than those in group B at the greater curvature of the antrum(group A:2.00 ± 0.14 vs group B:1.40 ± 0.15,P = 0.012),the lesser curvature of the corpus(group A:2.00 ± 0.21 vs group B:1.07 ± 0.23,P = 0.017),and the greater curvature of the corpus(group A:1.20 ± 0.30vs group B:0.47 ± 0.21,P = 0.031).Group A showed significant higher intestinal metaplasia scores than group B only at the lesser curvature of the antrum(group A:2.10 ± 0.41 vs group B:1.12 ± 0.29,P = 0.035).CONCLUSION:H pylori-associated chronic gastritis expressed the mutant-type p53,which was significantly associated with more severe atrophic and metaplastic changes.H pylori eradication led to a significant reduction in the expression of the mutant-type p53.It is considered that H pylori-infected chronic gastritis is associated with a genetic instability that leads to gastric carcinogenesis,and H pylori eradication may prevent gastric cancer. | Masaaki Kodama Kazunari Murakami Tadayoshi Okimoto Ryugo Sato Koichiro Watanabe Toshio Fujioka | 2007 | World Journal of Gastroenterology2007，13，10： | 13 |
| 3 | Influence of bile reflux and Helicobacter pylori infection on gastritis in the remnant gastric mucosa after distal gastrectomy显示文摘 | Hisanori Abe Kazunari Murakami Shunzo Satoh Ryugo Sato Masaaki Kodama Tsuyoshi Arita Toshio Fujioka | 2005 | Journal of Gastroenterology2005，，6： | 4 |
| 4 | Ten-year prospective follow-up of histological changes at five points on the gastric mucosa as recommended by the updated Sydney system after Helicobacter pylori eradication显示文摘 | Masaaki Kodama Kazunari Murakami Tadayoshi Okimoto Ryugo Sato Masahiro Uchida Takashi Abe Seiji Shiota Yoshifumi Nakagawa Kazuhiro Mizukami Toshio Fujioka | 2012 | Journal of Gastroenterology2012，，4： | 4 |
| 5 | Influence of bile reflux and Helicobacter pylori infection on gastritis in the remnant gastric mucosa after distal gastrectomy显示文摘 | Hisanori Abe Kazunari Murakami Shunzo Satoh Ryugo Sato Masaaki Kodama Tsuyoshi Arita Toshio Fujioka | 2005 | Journal of Gastroenterology2005，，6： | 1 |
| 6 | Duodenal gangliocytic paraganglioma treated with endoscopic hemostasis and resection显示文摘 | Takayuki Nagai Ryutarou Torishima Hiroshi Nakashima Jin Tanahashi Megumi Iwata Hitoshi Ookawara Shigeo Yokoyama Kazuhiro Yada Ryugo Sato Kazunari Murakami Toshio Fujioka | 2004 | Journal of Gastroenterology2004，，3： | 1 |
| 7 | Effect of Helicobacter pylori eradication on platelet recovery in patients with chronic idiopathic thrombocytopenic purpura显示文摘 | RYUGO SATO MD KAZUNARI MURAKAMI MD Koichiro Watanabe MD | 2004 | Arch Entern med2004，164，17： | 1 |
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