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| 1 | Downregulation of cyclooxygenase-1 is involved in gastric mucosal apoptosis via death signaling in portal hypertensive rats显示文摘门高血压(PHT ) gastropathy 是肝肝硬化的经常的复杂并发症,带之一从肝硬化死亡引起。Apoptosis 广泛地被认为从坏死的房间死亡是房间死亡和一个不同实体的一个活跃精力依赖者模式。胃的 mucosal apoptosis 是否涉及 PHT gastropathy,是不清楚的。通过 cyclooxygenase (艇长) 生产的前列腺素(PG ) 被认为从损害和 apoptosis 在胃肠的 mucosa 的保护起一个关键作用。然而,在 PHT gastropathy 的艇长的角色仍然不清楚地被理解。这研究的目的是调查(1 ) 胃的 mucosal apoptosis 是否涉及 PHT gastropathy,(2 ) 艇长的 downregulation 贡献这 apoptosis。在这研究,当 mucosal 增长在 PHT 老鼠被禁止时,我们证明胃的 mucosal apoptosis 显著地被增加。胃的 mucosal COX-1 显著地在 mRNA 和蛋白质层次被压制,并且 PGE2 在 PHT 老鼠被减少。进一步, PGE2 处理在 PHT 老鼠压制了胃的 mucosal apoptosis。然而,胃的 mucosal COX-2 层次没在假冒操作老鼠和 PHT 老鼠之间不同。肿瘤坏死因素的胃的 mucosal 层次 --(TNF-) 并且船边交货 ligand,然而并非 TNF 相关的导致 apoptosis ligand,被增加,并且激活的 caspase-8 和 caspase-3 层次是在 PHT 老鼠的 upregulated。到 cytosol 的从线粒体的细胞色素 c 的版本没在 PHT 老鼠被观察。我们的数据显示 COX-1 的 downregulation 经由死亡涉及胃的 mucosal apoptosis 调停信号的类型 -- 我在 PHT 老鼠的房间死亡。 | Bin Wu Lixian Zeng Ying Lin Zhuofu Wen Guihua Chen Ryuichi Iwakiri Kazuma Fujimoto | 2009 | Cell Research2009，19，11： | 6 |
| 2 | Risk factors for complications of endoscopic submucosal dissection in gastric tumors: analysis of 478 lesions显示文摘 | Kotaro Mannen Seiji Tsunada Megumi Hara Kanako Yamaguchi Yasuhisa Sakata Takehiro Fujise Takahiro Noda Ryo Shimoda Hiroyuki Sakata Shinichi Ogata Ryuichi Iwakiri Kazuma Fujimoto | 2010 | Journal of Gastroenterology2010，，1： | 3 |
| 3 | Risk factors for complications of endoscopic submucosal dissection in gastric tumors: analysis of 478 lesions显示文摘 | Kotaro Mannen Seiji Tsunada Megumi Hara Kanako Yamaguchi Yasuhisa Sakata Takehiro Fujise Takahiro Noda Ryo Shimoda Hiroyuki Sakata Shinichi Ogata Ryuichi Iwakiri Kazuma Fujimoto | 2010 | Journal of Gastroenterology2010，，1： | 3 |
| 4 | A pilot randomized control study to evaluate endoscopic resection using a ligation device for rectal carcinoid tumors显示文摘瞄准:比 10 公里小的直肠的良性肿瘤肿瘤能是有用内视镜检查法的本地切除的 resected。以便完全移开直肠的良性肿瘤肿瘤,我们在这飞行员控制与一台结扎设备评估了内视镜的粘膜切除术使随机化的学习。方法:十五个病人从 1993 ~ 2002 在我们的医院里与直肠的良性肿瘤肿瘤(不到 10 公里) 被诊断。有 9 男性和 6 女性,与吝啬的年龄 61.5 年(范围, 34-77 年) 。病人没有良性肿瘤症候群症状的抱怨。十五个病人随机被划分成 2 个组:7 个良性肿瘤肿瘤被常规内视镜的切除术治疗,并且 8 个良性肿瘤肿瘤被内视镜的切除术用一台结扎设备治疗。结果:所有直肠的良性肿瘤肿瘤在中间被定位到远侧的直肠。从 3 公里改变到 10 公里和病人的背景特征的肿瘤的尺寸不在二个组是不同的。用一台结扎设备的良性肿瘤肿瘤的完全的移动的率(100% , 8/8 ) 比常规内视镜的切除术的显著地高(57.1% , 4/7 ) 。三个病人有深边缘,另外的治疗为被执行的肿瘤参与。没有复杂并发症用一台结扎设备发生了在期间或在内视镜的切除术以后。在两个组的所有病人在 3 年的观察时期期间是活着的。结论:用一台结扎设备的内视镜的切除术是为小直肠的良性肿瘤肿瘤的切除术的一个有用、安全的方法。 | Hiroyuki Sakata Ryuichi Iwakiri Akifumi Ootani Seiji Tsunada Shinichi Ogata Hibiki Ootani Ryo Shimoda Kanako Yamaguchi Yasuhisa Sakata Sadahiro Amemori Kotaro Mannen Masanobu Mizuguchi Kazuma Fujimoto | 2006 | World Journal of Gastroenterology2006，12，25： | 2 |
| 5 | Guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment显示文摘 | Kazuma Fujimoto Mitsuhiro Fujishiro Mototsugu Kato Kazuhide Higuchi Ryuichi Iwakiri Choitsu Sakamoto Shinichiro Uchiyama Atsunori Kashiwagi Hisao Ogawa Kazunari Murakami Tetsuya Mine Junji Yoshino Yoshikazu Kinoshita Masao Ichinose Toshiyuki Matsui | 2014 | Digestive Endoscopy2014，，： | 2 |
| 6 | Endoscopic hemostasis for bleeding gastric varices treated by combination of variceal ligation and sclerotherapy with N-butyl-2-cyanoacrylate显示文摘 | Nozomi Sugimoto Kenichiro Watanabe Kazuyo Watanabe Shinichi Ogata Ryo Shimoda Hiroyuki Sakata Yuichiro Eguchi Toshihiko Mizuta Seiji Tsunada Ryuichi Iwakiri Junichi Nojiri Masanobu Mizuguchi Sho Kudo Kohji Miyazaki Kazuma Fujimoto | 2007 | Journal of Gastroenterology2007，，7： | 1 |
| 7 | Venous congestion induces mucosal apoptosis via tumor necrosis factor-α-mediated cell death in the rat small intestine显示文摘 | Bin Wu Takehiro Fujise Ryuichi Iwakiri Akifumi Ootani Sadahiro Amemori Seiji Tsunada Shuji Toda Kazuma Fujimoto | 2004 | Journal of Gastroenterology2004，，11： | 1 |
| 8 | Clinical Symptoms in Endoscopic Reflux Esophagitis: Evaluation in 8031 Adult Subjects显示文摘 | Kazuyo Okamoto Ryuichi Iwakiri Mitsuru Mori Megumi Hara Kayoko Oda Akiko Danjo Akifumi Ootani Hiroyuki Sakata Kazuma Fujimoto | 2003 | Digestive Diseases and Sciences2003，，12： | 1 |
| 9 | Evaluation of hemostasis with soft coagulation using endoscopic hemostatic forceps in comparison with metallic hemoclips for bleeding gastric ulcers: a prospective, randomized trial显示文摘 | Seiichiro Arima Yasuhisa Sakata Shinichi Ogata Naoyuki Tominaga Nanae Tsuruoka Kotaro Mannen Ryosuke Shiraishi Ryo Shimoda Seiji Tsunada Hiroyuki Sakata Ryuichi Iwakiri Kazuma Fujimoto | 2010 | Journal of Gastroenterology2010，，5： | 1 |
| 10 | Evaluation of hemostasis with soft coagulation using endoscopic hemostatic forceps in comparison with metallic hemoclips for bleeding gastric ulcers: a prospective, randomized trial显示文摘 | Seiichiro Arima Yasuhisa Sakata Shinichi Ogata Naoyuki Tominaga Nanae Tsuruoka Kotaro Mannen Ryosuke Shiraishi Ryo Shimoda Seiji Tsunada Hiroyuki Sakata Ryuichi Iwakiri Kazuma Fujimoto | 2010 | Journal of Gastroenterology2010，，5： | 1 |
| 11 | Characteristics of patients with non‐variceal upper gastrointestinal bleeding taking antithrombotic agents显示文摘 | Daisuke Yamaguchi Yasuhisa Sakata Nanae Tsuruoka Ryo Shimoda Toru Higuchi Hiroyuki Sakata Kazuma Fujimoto Ryuichi Iwakiri | 2015 | Digestive Endoscopy2015，，1： | 1 |
| 12 | Clinical outcomes of EMR for gastric tumors: historical pilot evaluation between endoscopic submucosal dissection and conventional mucosal resection显示文摘 | Kenichiro Watanabe Shinichi Ogata Seiji Kawazoe Kazuyo Watanabe Takanori Koyama Tetsuro Kajiwara Yuichiro Shimoda Yukari Takase Kouji Irie Masanobu Mizuguchi Seiji Tsunada Ryuichi Iwakiri Kazuma Fujimoto | 2006 | Gastrointestinal Endoscopy2006，，6： | 1 |
| 13 | Clinical Outcomes of Endoscopic Mucosal Resection for Gastric Tumors: Historical Comparison Between Endoscopic Submucosal Dissection and Conventional Mucosal Resection显示文摘 | Kenichiro Watanabe Shinichi Ogata Kazuyo Watanabe Seiji Kawazoe Seiji Tsunada Ryuichi Iwakiri Kazuma Fujimoto | 2005 | Gastrointestinal Endoscopy2005，，5： | 1 |
| 14 | Endoscopic hemostasis for bleeding gastric varices treated by combination of variceal ligation and sclerotherapy with N-butyl-2-cyanoacrylate显示文摘 | Nozomi Sugimoto Kenichiro Watanabe Kazuyo Watanabe Shinichi Ogata Ryo Shimoda Hiroyuki Sakata Yuichiro Eguchi Toshihiko Mizuta Seiji Tsunada Ryuichi Iwakiri Junichi Nojiri Masanobu Mizuguchi Sho Kudo Kohji Miyazaki Kazuma Fujimoto | 2007 | Journal of Gastroenterology2007，，7： | 1 |
| 15 | Case series of endoscopic balloon dilation to treat a stricture caused by circumferential resection of the gastric antrum by endoscopic submucosal dissection显示文摘 | Seiji Tsunada Shinichi Ogata Kotaro Mannen Seiichiro Arima Yasuhisa Sakata Ryosuke Shiraishi Ryo Shimoda Hibiki Ootani Kanako Yamaguchi Takehiro Fujise Hiroyuki Sakata Ryuichi Iwakiri Kazuma Fujimoto | 2008 | Gastrointestinal Endoscopy2008，，6： | 1 |
| 16 | Endoscopic hemostasis for bleeding gastric varices treated by combination of variceal ligation and sclerotherapy with N-butyl-2-cyanoacrylate显示文摘 | Nozomi Sugimoto Kenichiro Watanabe Kazuyo Watanabe Shinichi Ogata Ryo Shimoda Hiroyuki Sakata Yuichiro Eguchi Toshihiko Mizuta Seiji Tsunada Ryuichi Iwakiri Junichi Nojiri Masanobu Mizuguchi Sho Kudo Kohji Miyazaki Kazuma Fujimoto | 2007 | Journal of Gastroenterology2007，，7： | 1 |
| 17 | Proportion of reflux esophagitis in 6010 Japanese adults: prospective evaluation by endoscopy显示文摘 | Noriaki Furukawa Ryuichi Iwakiri Takanori Koyama Kazuyo Okamoto Toshifumi Yoshida Yoichiro Kashiwagi Takashi Ohyama Takahiro Noda Hiroyuki Sakata Kazuma Fujimoto | 1999 | Journal of Gastroenterology1999，，4： | 1 |
| 18 | Evaluation of hemostasis with soft coagulation using endoscopic hemostatic forceps in comparison with metallic hemoclips for bleeding gastric ulcers: a prospective, randomized trial显示文摘 | Seiichiro Arima Yasuhisa Sakata Shinichi Ogata Naoyuki Tominaga Nanae Tsuruoka Kotaro Mannen Ryosuke Shiraishi Ryo Shimoda Seiji Tsunada Hiroyuki Sakata Ryuichi Iwakiri Kazuma Fujimoto | 2010 | Journal of Gastroenterology2010，，5： | 1 |
| 19 | Clinical Symptoms in Endoscopic Reflux Esophagitis: Evaluation in 8031 Adult Subjects显示文摘 | Kazuyo Okamoto Ryuichi Iwakiri Mitsuru Mori Megumi Hara Kayoko Oda Akiko Danjo Akifumi Ootani Hiroyuki Sakata Kazuma Fujimoto | 2003 | Digestive Diseases and Sciences2003，，12： | 1 |
| 20 | Proportion of reflux esophagitis in 6010 Japanese adults: prospective evaluation by endoscopy显示文摘 | Noriaki Furukawa Ryuichi Iwakiri Takanori Koyama Kazuyo Okamoto Toshifumi Yoshida Yoichiro Kashiwagi Takashi Ohyama Takahiro Noda Hiroyuki Sakata Kazuma Fujimoto | 1999 | Journal of Gastroenterology1999，，4： | 1 |
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