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| 1 | Angiotensin Ⅱ receptor blocker provides pancreatic β-cell protection independent of blood pressure lowering in diabetic db/db mice显示文摘如果开发这研究的类型 2 diabetes.Theaim 的风险减小是调查是否并且长期的 candesartan 处理怎么能在 diabetesstate.Methods 稀释活动过度的本地intra小岛高血压蛋白原酶血管收缩素系统的 thedeleterious 影响,几流行病学的研究建议了处理 withangiotensin II 打 1 受体 blocker : Eight-week-old db/db 老鼠被使随机化到 candesartan 1 mg/kg , candesartan 10mg/kg , manidipine 经由为 6 w 的 gavage 的 10 mg/kg 。 | Jia-qing SHAO Noseki IWASHITA Hong DU Yang-tian WANG Yan-yan WANG Ming ZHAO Jian WANG Hirotaka WATADA Ryuzo KAWAMORI | 2007 | Acta Pharmacologica Sinica2007，28，2： | 11 |
| 2 | Classifying genotype F of hepatitis B virus into F1 and F2 subtypes显示文摘AIM: To explore the propriety of providing hepatitis B virus(HBV) genotypes F and H with two distinct genotypes.METHODS: Eleven HBV isolates of genotype F (HBV/F)were recovered from patients living in San Francisco,Japan, Panama, and Venezuela, and their full-length sequences were determined. Phylogenetic analysis was carried out among them along with HBV isolates previously reported.RESULTS: Seven of them clustered with reported HBV/F isolates in the phylogenetic tree constructed on the entire genomic sequence. The remaining four flocked on another branch along with three HBV isolates formerly reported as genotype H. These seven HBV isolates, including the four in this study and the three reported, had a sequence divergence of 7.3-9.5% from the other HBV/F isolates,and differed by > 13.7% from HBV isolates of the other six genotypes (A-E and G). Based on a marked genomic divergence, falling just short of >8% separating the seven genotypes, these seven HBV/F isolates were classified into F2 subtype and the former seven into F1 subtype provisionally. In a pairwise comparison of the S-gene sequences among the 7 HBV/F2 isolates and against 47HBV/F1 isolates as well as 136 representing the other six genotypes (A-E and G), two clusters separated by distinct genetic distances emerged.CONCLUSION: Based on these analyses, classifying HBV/F isolates into two subtypes (F1 and F2) would be more appropriate than providing them with two distinct genotypes (F and H). | Hideaki Kato Kei Fujiwara Robert G. Gish Hiroshi Sakugawa Hiroshi Yoshizawa Fuminaka Sugauchi Etsuro Orito Ryuzo Ueda Yasuhito Tanaka Takanobu Kato Yuzo Miyakawa Masashi Mizokami | 2005 | World Journal of Gastroenterology2005，11，40： | 6 |
| 3 | 2-氯-5-三氟甲基吡啶的生产及其在新农药设计上的应用显示文摘1977年,日本石原产业公司的科学家发现了在植物中输导选择性非凡、极为有效的狭叶杂草除草剂吡氟丁禾灵(fluazifop-butyl)[Ⅰ]。吡氟丁禾灵已在世界范围的棉花、大豆、烟草等阔叶作物田应用,防除狭叶杂草。 | Ryuzo Nishiyama 周红晞 | 1993 | 农药译丛1993，15，2： | 3 |
| 4 | Distribution of HBV genotypes among HBV carriers in Benin:phylogenetic analysis and virological characteristics of HBV genotype E显示文摘AIM: To determine the distribution of Hepatitis B virus (HBV) genotypes in Benin, and to clarify the virological characteristics of the dominant genotype.METHODS: Among 500 blood donors in Benin, 21 HBsAg-positive donors were enrolled in the study. HBV genotypes were determined by enzyme immunoassay and restriction fragment length polymorphism. Complete genome sequences were determined by PCR and direct sequencing.RESULTS: HBV genotype E (HBV/E) was detected in 20/21 (95.2%), and HBV/A in 1/21 (4.8%). From the age-specific prevalence of HBeAg to anti-HBe seroconversion (SC) in 19 HBV/E subjects, SC was estimated to occur frequently in late teens in HBV/E.The comparison of four complete HBV/E genomes from HBeAg-positive subjects in this study and five HBV/E sequences recruited from the database revealed that HBV/E was distributed throughout West Africa with very low genetic divers ity (nucleotide homology 96.7-99.2%).Based on the sequences in the basic core promoter (BCP)to precore region of the nine HBV/E isolates compared to those of the other genotypes, a nucleotide substitution in the BCP, G1757A, was observed in HBV/E.CONCLUSION: HBV/E is predominant in the Republic of Benin, and SC is estimated to occur in late teens in HBV/E. The specific nucleotide substitution G1757A in BCP, which might influence the virological characteristics,is observed in HBV/E. | Kei Fujiwara Yasuhito Tanaka Etsuro Orito Tomoyoshi Ohno Takanobu Kato Kanji Sugihara Izumi Hasegawa Mayumi Sakurai Kiyoaki Ito Atsushi Ozasa Yuko Sakamoto Isao Arita Ahmed El-Gohary Agossou Benoit Sophie I Ogoundele-Akplogan Namiko Yoshihara Ryuzo Ueda Masashi Mizokami | 2005 | World Journal of Gastroenterology2005，11，41： | 3 |
| 5 | Genotype and phylogenetic characterization of hepatitis B virus among multi-ethnic cohort in Hawaii显示文摘AIM: Hepatitis B virus (HBV) genomes in carriers from Hawaii have not been evaluated previously. The aim of thepresent study was to evaluate the distribution of HBV genotypes and their clinical relevance in Hawaii.METHODS: Genotyping of HBV among 61 multi-ethnicc arriers in Hawaii was performed by genetic methods.Three complete genomes and 61 core promoter/precore regions of HBV were sequenced directly.RESULTS: HBV genotype distribution among the 61 carderswas 23.0% for genotype A, 14.7% for genotype B and 62.3% for genotype C. Genotypes A, B and C were obtained from the carriers whose ethnicities were Filipino and Caucasian,Southeast Asian, and various Asian and Micronesian,respectively. All cases of genotype B were composed of recombinant strains with genotype C in the precore plus core region named genotype Ba. HBeAg was detected more frequently in genotype C than in genotype B (68.4% vs 33.3%, P<0.05) and basal core promoter (BCP) mutation (T1762/A1764) was more frequently found in genotype C than in genotype B. Twelve of the 38 genotype C strains possessed C at nucleotide (nt) position 1858 (C-1858).However there was no significant difference in clinical characteristics between C-1858 and T-1858 variants. Based on complete genome sequences, phylogenetic analysis revealed one patient of Micronesian ethnicity as having C1858 clustered with two isolates from Polynesia with T-1858.In addition, two strains from Asian ethnidties were clustered with known isolates in carriers from Southeast Asia.CONCLUSION: Genotypes A, B and C are predominant types among multi-ethnic HBV carriers in Hawaii, and distribution of HBV genotypes is dependent on the ethnic background of the carriers in Hawaii. | Mayumi Sakurai Fuminaka Sugauchi Naoky Tsai Seiji Suzuki Izumi Hasegawa Kei Fujiwara Etsuro Orito Ryuzo Ueda Masashi Mizokami | 2004 | World Journal of Gastroenterology2004，10，15： | 2 |
| 6 | Reactivation of hepatitis B virus following systemic chemotherapy for malignant lymphoma显示文摘 | Shigeru Kusumoto Yasuhito Tanaka Masashi Mizokami Ryuzo Ueda | 2009 | International Journal of Hematology2009，，1： | 2 |
| 7 | Smoking Increases the Treatment Failure for Helicobacter pylori Eradication显示文摘 | Takeshi Suzuki Keitaro Matsuo Hidemi Ito Akira Sawaki Kaoru Hirose Kenji Wakai Shigeki Sato Tsuneya Nakamura Kenji Yamao Ryuzo Ueda Kazuo Tajima | 2006 | The American Journal of Medicine2006，，3： | 2 |
| 8 | Non-ossifying fibromas: Case series, including in uncommon upper extremity sites显示文摘AIM To investigate non-ossifying fibromas(NOFs) common fibrous bone lesions in children that occur in bones of the lower extremities.METHODS We analyzed 44 cases of NOF including 47 lesions, which were referred with a working diagnosis of neoplastic lesions. Lesions were located in the upper extremities(1 proximal humerus, 1 distal radius) and the lower extremities(25 distal femurs, 12 proximal and 4 distal tibias, and 4 proximal fibulas).RESULTS Three cases had NOFs in multiple anatomical locations(femur and fibula in 1 case, femur and tibia in 2 cases). Overall, larger lesions > 4 cm and lesion expansion at the cortex were seen in 21% and 32% of cases, respectively. Multiple lesions with bilateral symmetry in the lower extremities suggest that these NOFs were developmental bone defects. Two patients suffered from fracture and were treated without surgery, one in the radius and one in the femur. Lesions in the upper extremities(i.e., humerus of a 4-year-old female and radius of a 9-year-old male) expanded at the cortex and lesion size increased with slow ossification.CONCLUSION NOFs in the lower extremity had fewer clinical problems, regardless of their size and expansiveness. In these two upper extremity cases, the NOFs had aggressive biological features. It seems that there is a site specific difference, especially between the upper extremity and the lower extremity. Furthermore, NOFs in the radius are predisposed to fracture because of the slender structure of the radius and the susceptibility to stress. | Akio Sakamoto Ryuzo Arai Takeshi Okamoto Shuichi Matsuda | 2017 | World Journal of Orthopedics2017，8，7： | 2 |
| 9 | Mechanical-Alloying-Assisted Synthesis of Ti3SiC2 Powder显示文摘 | Jing-feng Li Toshiro Matsuki and Ryuzo Watanabe | 2002 | Journal of the American Ceramic Society2002，4，： | 1 |
| 10 | Inflammatory pseudotumor of the Liver,Clinicopathologic study and review of the Literature显示文摘 | Toshikazu uchida Takashi Kojima | 1990 | Cancer1990，65，7： | 1 |
| 11 | New retinoids and arsenic compounds for the treatment of refractory acute promyelocytic leukemia: clinical and basic studies for the next generation显示文摘 | Kunio Kitamura Hitoshi Kiyoi Hitoshi Yoshida Tadasu Tobita Akihiro Takeshita Ryuzo Ohno Tomoki Naoe | 1997 | Cancer Chemotherapy and Pharmacology1997，，1： | 1 |
| 12 | Erythropoietin: Multiple Physiological Functions and Regulation of Biosynthesis显示文摘 | Ryuzo SASAKI Seiji MASUDA Masaya NAGAO | 2000 | Bioscience, Biotechnology, and Biochemistry2000，，9： | 1 |
| 13 | Concept and P/M Fabrication of Functionally Gradient Materials 显示文摘 | Kawasaki Akira Watanabe Ryuzo | 1997 | Ceramics International1997，23，1： | 1 |
| 14 | Determination of meat quality by texture analysis显示文摘 | Kazuhiko Shiranita Tsuneharu Miyajima Ryuzo Takiyama | 1998 | PatternRecognition Letters1998，19，： | 1 |
| 15 | Epidemiologic and virologic characteristics of hepatitis B virus genotype B having the recombination with genotype C显示文摘 | Fuminaka Sugauchi Etsuro Orito Takafumi Ichida Hideaki Kato Hiroshi Sakugawa Shinichi Kakumu Takafumi Ishida Anuchit Chutaputti Ching-Ling Lai Robert G. Gish Ryuzo Ueda Yuzo Miyakawa Masashi Mizokami | 2003 | Gastroenterology2003，，4： | 1 |
| 16 | Treatment of adult patients with philadelphia chromosome-positive acute lymphoblastic leukemia显示文摘 | Ryuzo Ohno | 2008 | Current Oncol Rep2008，10，5： | 1 |
| 17 | The optical resolution and asymmetric transformation of DL-p-hydroxypheny glycine with (+)-1-phenylethanesulfonic acid显示文摘 | Yoshioka Ryuzo | 1987 | Bull Chem Soc Jpn1987，60，64： | 1 |
| 18 | Angiogenic properties of sustained release platelet-rich plasma: Characterization in-vitro and in the ischemic hind limb of the mouse显示文摘 | Shyamal Chandra Bir Jiro Esaki Akira Marui Kenichi Yamahara Hideki Tsubota Tadashi Ikeda Ryuzo Sakata | 2009 | Journal of Vascular Surgery2009，，4： | 1 |
| 19 | Combustion Reaction During Mechanical Alloying Synthesis of Ti_3SiC_2 Ceramics from 3Ti/Si/2C Powder Mixture显示文摘 | Jing Feng Li Toshiro Matsuki Ryuzo Watanabe | 2005 | Journal of the American Ceramic Society2005，5，： | 1 |
| 20 | Inhibition of sarcolemmal Na+,K+-ATPase activity reduces the infarct size-limiting effect of preconditioning in rabbit hearts显示文摘 | Ryuzo N Tomoyuki M Tomoyuki I | 1997 | Circulation1997，96，2： | 1 |
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