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| 1 | miRNA expression profiles in cerebrospinal fluid and blood of patients with Alzheimer’s disease and other types of dementia-an exploratory study显示文摘Background:MicroRNAs(miRNAs)are small non-coding RNA molecules that function as posttranscriptional regulators of gene expression.Measurements of miRNAs in cerebrospinal fluid(CSF)and blood have just started gaining attention as a novel diagnostic tool for various neurological conditions.The purpose of this exploratory investigation was to analyze the expression of miRNAs in CSF and blood of patients with Alzheimer’s disease(AD)and other neurodegenerative disorders in order to identify potential miRNA biomarker candidates able to separate AD from other types of dementia.Methods:CSF was collected by lumbar puncture performed on 10 patients diagnosed with AD and 10 patients diagnosed with either vascular dementia,frontotemporal dementia or dementia with Lewy bodies.Blood samples were taken immediately after.Total RNA was extracted from cell free fractions of CSF and plasma,and a screening for 372 known miRNA sequences was carried out by real time quantitative polymerase chain reactions(miRCURY LNA™Universal RT miRNA PCR,Polyadenylation and cDNA synthesis kit,Exiqon).Results:Fifty-two miRNAs were detected in CSF in at least nine out of ten patients in both groups.Among these,two miRNAs(let-7i-5p and miR-15a-5p)were found significantly up-regulated and one miRNA(miR-29c-3p)was found significantly down-regulated in patients with AD compared to controls.One hundred and sixty-eight miRNAs were frequently detected in the blood,among which miR-590-5p and miR-142-5p were significantly up-regulated and miR-194-5p was significantly down-regulated in AD patients compared to controls.Conclusions:Detection of miRNA expression profiles in blood and in particular CSF of patients diagnosed with different types of dementia is feasible and it seems that several expressional differences between AD and other dementia types do exist when measured in a clinically relevant setup.In this explorative pilot study,the deregulated miRNAs in CSF of AD patients may be associated with relevant target genes related to AD pathology,including APP and BACE1,which suggests that miRNAs are interesting candidates for AD biomarkers in the future. | Sofie Sølvsten Sørensen Ann-Britt Nygaard Thomas Christensen | 2016 | Translational Neurodegeneration2016，5，1： | 14 |
| 2 | Clinical Management of Hepatocellular Carcinoma. Conclusions of the Barcelona-2000 EASL Conference显示文摘 | Jordi Bruix Morris Sherman Josep M Llovet Michel Beaugrand Riccardo Lencioni Andrew K Burroughs Erik Christensen Luigi Pagliaro Massimo Colombo Juan Rodés | 2001 | Journal of Hepatology2001，，3： | 11 |
| 3 | Viral evasion of DNA-stimulated innate immune responses显示文摘导出病毒的 nucleic 酸的细胞的察觉到为对病毒感染的早防卫是必要的。在最近的年里,包括周期的 GMP 安培 synthase (cGAS ) 和 gamma-interferon-inducible 蛋白质(IFI16 ) ,察觉到蛋白质的 DNA 的发现导致了房间怎么对带 DNA 染色体的到来的病原体唤起强壮的天生的有免疫力的回答的理解。发信号由 DNA 传感器刺激了取决于适配器蛋白质圈套(干扰素基因的激发器) ,到启用抗病毒的蛋白质的表示,包括类型我干扰素。便于有效感染,病毒发展了大量避免策略,指向的主人 DNA 传感器,适配器蛋白质和抄写因素。在这评论, STING 小径的导致病毒的激活上的当前的文学被介绍,我们讨论在这条抗病毒的小径指向不同的步的最近识别的病毒的避免机制。 | Maria H Christensen Sфren R Paludan | 2017 | Cellular & Molecular Immunology2017，14，1： | 4 |
| 4 | Targeting Dexamethasone to Macrophages in a Porcine Endotoxemic Model显示文摘 | Asger Granfeldt Christine Lodberg Hvas Jonas Heilskov Graversen Peter Astrup Christensen Mikkel Due Petersen Gabriela Anton Pia Svendsen Christoffer S?lling Anders Etzerodt Else T?nnesen S?ren Kragh Moestrup Holger Jon M?ller | 2013 | Critical Care Medicine2013，，11： | 2 |
| 5 | Active Crohn’s disease is associated with low vitamin D levels显示文摘 | S?ren Peter J?rgensen Christian Lodberg Hvas J?rgen Agnholt Lisbet Ambrosius Christensen Lene Heickendorff Jens Frederik Dahlerup | 2013 | Journal of Crohn’s and Colitis2013，，： | 2 |
| 6 | Chemometric exploration of an amperometric biosensor array for fast determination of wastewater quality 显示文摘 | TONNING E SAPELNIKOVA S CHRISTENSEN J | 2005 | Biosensorsand Bioelectronics2005，21，4： | 1 |
| 7 | Neutron stars,trace anomalies and the Hawking effect显示文摘 | Fulling S A | 1977 | Phys Rev D1977，15，： | 1 |
| 8 | IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4^+CD25^+ regulatory T cells显示文摘 | Vieira PL Christensen JR Minaee S | 2004 | J Immunol2004，172，10： | 1 |
| 9 | Clinical outcome in children with acute renal failure treated with peritoneal dialysis after surgery for congenital heart disease 显示文摘 | Pedersen K R Hjortdal V E Christensen S | 2008 | Kidney International2008，73，108： | 1 |
| 10 | Gene type classification of colorectal adenocarcinoma biologic behavior correlates with k-ras-2 muta- tion type显示文摘 | Finkelstein SD Sayegh R Christensen S | 1993 | Cancer1993，71，： | 1 |
| 11 | Interaction between ADH1C Arg(272)GIn and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer显示文摘 | BENZON LARSEN S VOGEL U CHRISTENSEN J | 2010 | Cancer I_ett2010，295，2： | 1 |
| 12 | Measurement of soil microbial biomass provides an early indication of chan- ges in total soil organic matter due to straw in corporation 显示文摘 | Powlson D S Brookes P C Christensen B | 1987 | Soil Biol Bioehem1987，19，： | 1 |
| 13 | Ultrasound- guided renal biopsy with biopsy gun techniqueefficacy and complications 显示文摘 | CHRISTENSEN J LINDEQUIST S KNUDSEN D U | 1995 | Acta Radiologica1995，36，3： | 1 |
| 14 | Source apportionment of PAHs in sediments using factor analysis by time records: application to Lake Michigan, USA显示文摘 | Christensen E R Arora S | 2007 | Water Research2007，41，1： | 1 |
| 15 | Preadmis-sion Use of Systemic Glucocorticoids and 30-Day Mortality Following Bleeding Peptic Ulcer: A Pop-ulation-Based Cohort Study显示文摘 | Olsen M Christensen S Riis A | 2010 | Am 1 Ther2010，17，1： | 1 |
| 16 | A role for flavin monooxygenase-like enzymes in auxin biosynthesis显示文摘 | ZHAO Y CHRISTENSEN S K FANKHAUSER C | 2001 | Science2001，291，5502： | 1 |
| 17 | A global movement toward an ecosystem approach to management of marine resources显示文摘 | Sherman K Sissenwine M Christensen V Duda A Hempel G Ibe C Levin S Liuch-Belda D Matishov G McGlade J O'Toole M Switzinger S Serra R Skjoldat H-R Tang Q Thulin J Vandeweerd V Zwanenburg K | | 0，，： | 1 |
| 18 | Fluids in hydrocarbon basins显示文摘 | Pedersen K S Christensen P L | 2007 | Reviews in Mineralogy and Geochemistry2007，65，1： | 1 |
| 19 | Failure of collateral blood flow is associated with infarct growth in ischemic stroke显示文摘 | Campbell BC Christensen S Tress BM | 2013 | J Cereb Blood Flow Metab2013，33，8： | 1 |
| 20 | Clinical outcome in children with acute renal failure treated with Peritoneal dialysis after surgery for congenital heart disease显示文摘 | Pedersen KR Hjortdal Christensen S | 2008 | Kidney Int Suppl2008，，108： | 1 |
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