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| 1 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 2 | Plecanatide-mediated activation of guanylate cyclase-C suppresses inflammation-induced colorectal carcinogenesis in Apc+/Min-FCCC mice显示文摘AIM To evaluate the effect of orally administered plecanatide on colorectal dysplasia in Apc^(+/Min-FCCC) mice with dextran sodium sulfate(DSS)-induced inflammation. METHODS Inflammation driven colorectal carcinogenesis was induced in Apc^(+/Min-FCCC) mice by administering DSS in their drinking water. Mice were fed a diet supplemented with plecanatide(0-20 ppm) and its effect on the multiplicity of histopathologically confirmed polypoid,flat and indeterminate dysplasia was evaluated. Plecanatide-mediated activation of guanylate cyclase-C(GC-C) signaling was assessed in colon tissues by measuring cyclic guanosine monophosphate(cG MP) by ELISA, protein kinase G-II and vasodilator stimulated phosphoprotein by immunoblotting. Ki-67, c-myc and cyclin D1 were used as markers of proliferation. Cellular levels and localization of b-catenin in colon tissues were assessed by immunoblotting and immunohistochemistry, respectively. Uroguanylin(UG) and GC-C transcript levels were measured by quantitative reverse transcription polymerase chain reaction(RT-PCR). A mouse cytokine array panel was used to detect cytokines in the supernatant of colon explant cultures. RESULTS Oral treatment of Apc^(+/Min-FCCC) mice with plecanatide produced a statistically significant reduction in the formation of inflammation-driven polypoid, flat and indeterminate dysplasias. This anti-carcinogenic activity of plecanatide was accompanied by activation of cG MP/GC-C signaling mediated inhibition of Wnt/b-catenin signaling and reduced proliferation. Plecanatide also decreased secretion of pro-inflammatory cytokines(IL-6, IL-1 TNF), chemokines(MIP-1, IP-10) and growth factors(GCSF and GMCSF) from colon explants derived from mice with acute DSS-induced inflammation. The effect of plecanatidemediated inhibition of inflammation/dysplasia on endogenous expression of UG and GC-C transcripts was measured in intestinal tissues. Although GC-C expression was not altered appreciably, a statistically significant increase in the level of UG transcripts was detected in the proximal small intestine and colon, potentially due to a reduction in intestinal inflammation and/or neoplasia. Taken together, these results suggest that reductions in endogenous UG, accompanied by dysregulation in GC-C signaling, may be an early event in inflammation-promoted colorectal neoplasia; an event that can potentially be ameliorated by prophylactic intervention with plecanatide.CONCLUSION This study provides the first evidence that orally administered plecanatide reduces the multiplicity of inflammation-driven colonic dysplasia in mice, demonstrating the utility for developing GC-C agonists as chemopreventive agents. | Wen-Chi L Chang Shet Masih Anusha Thadi Viren Patwa Apoorva Joshi Harry S Cooper Vaseem A Palejwala Margie L Clapper Kunwar Shailubhai | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 5 |
| 3 | Response of blood pressure after percutaneous transluminal renal artery angioplasty and stenting显示文摘AIM: To evaluate the short and intermediate term out-come of percutaneous transluminal renal artery angioplasty (PTRA) and stenting particularly on blood pressure (BP) control and renal function and to evaluate predictors of poor BP response after successful PTRA and stenting. METHODS: We conducted a prospective analysis of all patients who underwent PTRA and stenting in our institute between August 2010 to September 2012. A total number of 86 patients were underwent PTRA and renal stenting. Selective angiography was done to confirm at least 70% angiographic stenosis. The predilatation done except few cases with critical stenosis, direct stenting was done in the rest of cases. All patients received aspirin 325 mg orally, and clopidogrel 300 mg orally within 24 h before the procedure. Heparin was used as the procedural anticoagulant agent. Optimal results with TIMI-Ⅲ flow obtained in all cases. Following stent placement, aspirin 150 mg orally once daily was continued for a minimum of 12 mo and clopidogrel 75 mg orally once daily for at least 4 wk. The clinical, radiological, electrocardiography, echocardiography and treatment data of all patients were recorded. The BP measurement, serum creatinine and glomerular filtration rate (GFR) were recorded before the procedure and 1 and 6 mo after PTRA. RESULTS: A total of 86 patients were included in the study. The mean age of study population was 55.87±11.85 years old and 67 (77.9%) of patients were male. There was a significant reduction in both systolic and diastolic BP at 1 mo after the procedure: 170.15±20.10 mmHg vs 146.60±17.32 mmHg and 98.38±10.55 mmHg vs 89.88±9.22 mmHg respectively (P=0.0000). The reduction in BP was constant throughout the follow-up period and was evident 6 mo after the procedure: 144.23±18.19 and 88.26±9.79 mmHg respectively (P=0.0000). However, no improvement in renal function was observed at any time during the follow-up period. After multivariate analysis, we found male sex, low GFR (<60 mL/min) and higher baseline mean BP as a poor predictors of successful outcome on BP response after PTRA and stenting. CONCLUSION: The PTRA and stenting can be considered as an effective therapeutic intervention for improving BP control with minimal effect on renal function. The male sex, higher baseline BP and low GFR are associated with poor BP response after successful PTRA and stenting. | Jayesh S Prajapati Sharad R Jain Hasit Joshi Shaurin Shah Kamal Sharma Sibasis Sahoo Kapil Virparia Ashok Thakkar | 2013 | World Journal of Cardiology2013，5，7： | 3 |
| 4 | Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention显示文摘 | Debasis Bagchi Manashi Bagchi Sidney J Stohs Dipak K Das Sidhartha D Ray Charles A Kuszynski Shantaram S Joshi Harry G Pruess | 2000 | Toxicology2000，，2： | 3 |
| 5 | Lens aldose reductase inhibiting potential of some indigenous plants显示文摘 | N Halder S Joshi S.K Gupta | 2003 | Journal of Ethnopharmacology2003，，1： | 2 |
| 6 | Structural and electrical characteristics of rapid thermally processed ferroelectric Bi4Ti3O12 thin films prepared by metalorganic solution deposition technique显示文摘 | JOSHI P C DESU S B | 1996 | J Appl Phys1996，80，4： | 2 |
| 7 | A MUSIC-like method for estimating quadratic phase coupling显示文摘 | H Parthasarathy S Prasad S D Joshi | 1994 | Sig Process1994，37，： | 2 |
| 8 | Optimum design of multiple-impeller selfinducing system显示文摘 | Patil S S Joshi J B | 2003 | Industrial and Engineering Chemistry Research2003，42，6： | 1 |
| 9 | Intratumoral FOXP3 expression in infiltrating breast carcinoma: Its association with clinicopatholog- ic parameters and angiogenesis 显示文摘 | Gupta S Joshi K Wiq J D | 2007 | Acta Oncol2007，46，6： | 1 |
| 10 | Supplementation with flax oil and vitamin C improves the outcome of attention deficit hyperactivity disorder (ADHD) 显示文摘 | Joshi K Lad S Kale M | 2006 | Prostaglandins Leukot Essent Fatty Acids2006，74，1： | 1 |
| 11 | Free radical scavenging behavior of folic acid: evidence for possible antioxidant activity 显示文摘 | Joshi R Adhikari S Patro BS | 2001 | Free Radic Biol Med2001，30，： | 1 |
| 12 | Dynamic testing at high strain rates of an ultrafine-grained magnesium alloy processed by ECAP 显示文摘 | Li B Joshi S Azevedoa K | 2009 | Mater Sci Eng A2009，517，2429： | 1 |
| 13 | Noise Reduction for NMR FID Signal via Gabor Transform显示文摘 | S Joshi J M Morris | 1997 | IEEE Trans Biomedical Engineering1997，44，6： | 1 |
| 14 | Energy and exergy efficiencies of a hybrid photovoltaic-thermal (PV/T) air collector 显示文摘 | Anand S Joshi Arvind Tiwari | 2007 | Renewable Energy2007，32，： | 1 |
| 15 | High frequency of loss of allelic integrity at Wilms' tumor suppressor gene-llocus in advanced breast tumors associated with aggressiveness of the tumor显示文摘 | Gupta S Joshi K Wig JD | 2009 | Indian J Cancer2009，46，4： | 1 |
| 16 | Autoreactive T cell escape clonal deletion in the thymus by a CD24-dependent pathway显示文摘 | Carl J W Jr Liu J Q Joshi P S | 2008 | J Immunol2008，181，1： | 1 |
| 17 | Influence of fatty alcohol antifoam suspen-sions on foam stability显示文摘 | JOSHI K S JEELANIAS A K BLICKENSTORFERBC | 2005 | Coll Surf A:Phys Eng ASpects2005，263，： | 1 |
| 18 | International Journal of Powder Metallurgy显示文摘 | Joshi P B Krishnan P S Patel R H | 1998 | 34(4):63-741998，34，4： | 1 |
| 19 | Yield and quality of soymilk and tofu made from soybean genotypes grown at four locations显示文摘 | BHARDWAJ H L BHAGSARI A S JOSHI J M | 1999 | Crop Sci1999，39，： | 1 |
| 20 | Risk factors for early myocardial infarction in South Asians compared with individuals in other countries显示文摘 | Joshi P Islam S Pais P | 2007 | JAMA2007，297，3： | 1 |
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