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| 1 | 在肝的 G6PT-H6PDH-11HSD1 三个一组和它在新陈代谢的症候群的 pathomechanism 的含意显示文摘 The metabolic syndrome, one of the most common clinical conditions in recent times, represents a combination of cardiometabolic risk determinants, including central obesity, glucose intolerance, insulin resistance, dyslipidemia, non-alcoholic fatty liver disease and hypertension. Prevalence of the metabolic syndrome is rapidly increasing worldwide as a consequence of common overnutrition and consequent obesity. Although a unifying picture of the pathomechanism is still missing, the key role of the pre-receptor glucocorticoid activation has emerged recently. Local glucocorticoid activation is catalyzed by a triad composed of glucose-6-phosphate-transporter, hexose-6-phosphate dehydrogenase and 11β-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum. The elements of this system can be found in various cell types, including adipocytes and hepatocytes. While the contribution of glucocorticoid activation in adipose tissue to the pathomechanism of the metabolic syndrome has been well established, the relative importance of the hepatic process is less understood. This review summarizes the available data on the role of the hepatic triad and its role in the metabolic syndrome, by confronting experimental findings with clinical observations. | Ibolya Czegle Miklós Csala József Mandl Angelo Benedetti István Karádi Gábor Bánhegyi | 2012 | World Journal of Hepatology2012，4，4： | 2 |
| 2 | Recombinant yellow fever viruses are effective therapeutic vaccines for treatment of murine experimental solid tumors and pulmonary metastases显示文摘 | Mcallister A Arbetman A E Mandl S | 2000 | J Virol2000，74，： | 1 |
| 3 | High glucose increases prostaglandin E2 synthesis in human peritoneal mesothelial cells: role of hyperosmolarity显示文摘 | Sitter T Haslinger B Mandl S | 1997 | Kindey Int1997，51，1： | 1 |
| 4 | Effect of ion energy and chemistry on layer growth processes during nitriding of CoCr alloys 显示文摘 | Lutz J Mandl S | 2009 | Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms2009，267，89： | 1 |
| 5 | Adaptation of tick-borne encephalitis virus to BHK-21 ceils results in the for- mation of multiple heparan sulfate binding sites in the envelope protein and attenuation in Vivo 显示文摘 | MANDL C W KROSCHEWSKI H ALLISON S L | 2001 | J Virol2001，75，： | 1 |
| 6 | Investigation on plasma immersion ion implantation treated medical implants 显示文摘 | Sader R Krause D | 2002 | Biomol Eng2002，，19： | 1 |
| 7 | Investigation on plasma immersion ion implantation treated medical implants 显示文摘 | MANDL S SADER R KRAUSE D | 2002 | Biomol Eng2002，，19： | 1 |
| 8 | Absorption of carbon dioxide into aqueous blends of 2 amino-2-methyl-1-propanol and mono - ethanolamine显示文摘 | Mandl B P Bandyopadhyay S S | 2006 | Chemical Engineering Science2006，61，16： | 1 |
| 9 | Natural mutations lead to enhanced proteasomal degradation of human Ncb5or, a novel flavoheme reductase显示文摘 | Fanni S. Kálmán Beáta Lizák Szilvia K. Nagy Tamás Mészáros Veronika Zámbó József Mandl Miklós Csala éva Kereszturi | 2013 | Biochimie2013，，7： | 1 |
| 10 | The Earth Ob- serving One (EO-1 ) satellite mission:over a decade in space显示文摘 | Middleton E M Ungar S G Mandl D J | 2013 | IEEE Journal of Selected Topics in Applied Earth Obser- vations and Remote Sensing2013，6，2： | 1 |
| 11 | Wear behaviour of martensitic stainless steel after PIII surface treatment 显示文摘 | Manova D Mandl S Neumann H | 2005 | Surface and Coatings Technology2005，200，14： | 1 |
| 12 | Investigation on plasma immersion ion implantation treated medical implants 显示文摘 | Mandl S Sader R Krause D | 2002 | Biomol Eng2002，，19： | 1 |
| 13 | Investigation on plasma immersion ion implantation treated medical implants显示文摘 | S Mandl R Sader D Krause | 2002 | Biomol Eng2002，，19： | 1 |
| 14 | Investigation on plasma immersion ion implantation treated medical implants显示文摘 | Sader R Krause D | 2002 | Biomol Eng2002，，19： | 1 |
| 15 | Nitrogen plasma immersion ion implantstion into high epeed steel显示文摘 | Mandl S Richer E Gunzel R | 1999 | Nuclear Instruments & Methods in Physics Research1999，148，： | 1 |
| 16 | Secondary structure of the 3 '-noncoding region of flavivirus genomes:comparative analysis of base pairing probabilities显示文摘 | Rauscher S Flamm C Mandl CW | | 0，，07： | 1 |
| 17 | Endoplasmic reticulum: nutrient sensor in physiology and pathology显示文摘 | József Mandl Tamás Mészáros Gábor Bánhegyi László Hunyady Miklós Csala | 2009 | Trends in Endocrinology & Metabolism2009，，4： | 1 |
| 18 | Synthesis and secretion of recombinant tick-borne encephalitis vi- rus protein E in soluble and particulate form显示文摘 | Allison S L Stadler K Mandl C W | 1995 | J Virol1995，69，： | 1 |
| 19 | Stress on redox显示文摘 | Gábor Bánhegyi Angelo Benedetti Miklós Csala József Mandl | 2007 | FEBS Letters2007，，19： | 1 |
| 20 | Attention of tick-brone encephalitis virus by structure-based site-specific mutagenesis of a putative Flavivirus receptor binding site 显示文摘 | Allison S L Holzmann H | 2000 | J Virol2000，74，20： | 1 |
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