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| 1 | Choledochal cysts: Similarities and differences between Asian and Western countries显示文摘Choledochal cysts(CCs)are rare bile duct dilatations,intra-and/or extrahepatic,and have higher prevalence in the Asian population compared to Western populations.Most of the current literature on CC disease originates from Asia where these entities are most prevalent.They are thought to arise from an anomalous pancreaticobiliary junction,which are congenital anomalies between pancreatic and bile ducts.Some similarities in presentation between Eastern and Western patients exist such as female predominance,however,contemporary studies suggest that Asian patients may be more symptomatic on presentation.Even though CC disease presents with an increased malignant risk reported to be more than 10%after the second decade of life in Asian patients,this risk may be overstated in Western populations.Despite this difference in cancer risk,management guidelines for all patients with CC are based predominantly on observations reported from Asia where it is recommended that all CCs should be excised out of concern for the presence or development of biliary tract cancer. | George N Baison Morgan M Bonds William S Helton Richard A Kozarek | 2019 | World Journal of Gastroenterology2019，25，26： | 16 |
| 2 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 3 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 4 | Increasing starter cell lysis in Cheddar cheese using a bacteriocin- producing adjunct显示文摘 | MORGAN S ROSS R P HILL C | 1997 | J Dairy Sci1997，80，： | 2 |
| 5 | The commitment-trust theory of relationship marketing 显示文摘 | MORGAN R M HUNT S D | 1994 | Journal of Marketing1994，58，3： | 1 |
| 6 | A readout magnet for prepolarized MRI显示文摘 | Morgan P Conolly S Scott G | 1996 | Magn Reson Med1996，36，4： | 1 |
| 7 | Relation of beta2-adrenoceptorpolymorphisms at codons 16 and 27 to persistence of asthma symptoms after the onset of puberty显示文摘 | GUERRA S GRAVES PE MORGAN WJ | 2005 | Chest2005，128，2： | 1 |
| 8 | Cardiac troponin I measurement with the ACCESS immunoassay system:analytical and clinical performance characteristics 显示文摘 | Apple F S Morgan D L | 1998 | Clin Chem1998，44，： | 1 |
| 9 | The Commitment-Trust Theory of Relationship Marketing显示文摘 | HUNT D S | 1994 | Journal of Marketing Research1994，58，： | 1 |
| 10 | Prevention and delay in progression of human squan~ous cell carcinoma of the head and neck in nude mice by stable overexpression of the opioid growth factor receptor显示文摘 | McLaughlin PJ Krdner S Morgan CR | 2008 | Int J Oncol2008，33，4： | 1 |
| 11 | Preservation and fermentation: Past, present and future显示文摘 | ROSS R P MORGAN S HILL C | 2002 | International Journal of Food Microbiology2002，79，12： | 1 |
| 12 | Evaluation of the ergogenic properties of ginseng:an update显示文摘 | Bahrke M S Morgan W R | 2000 | Sports Med2000，29，2： | 1 |
| 13 | Lactolation of Beta-lactoglobulin Monitored by Electrospray Ionisation Mass Spectrometry显示文摘 | Morgan F Bouhallab S MOLLE D | 1998 | International Dairy Journal1998，8，2： | 1 |
| 14 | Dividend Stability, Dividend Yield and Stock Returns : UK Evidence 显示文摘 | Gwilym Oa Morgan G Thomas S | 2000 | Journal of Business Finance & Accounting2000，27，34： | 1 |
| 15 | Expression, processing, and assembly of foot-and-mouth disease virus capsid structures in heterologous systems: induction of a neutralizing antibody resp- onse in guinea pigs 显示文摘 | Lewis S Morgan D Grubman M | 1991 | J Virol1991，65，12： | 1 |
| 16 | Employee ownership:a conceptual model of process and effects显示文摘 | PIERCE J L RUBENFELD SA MORGAN S | 1991 | A- cademy of Management Review1991，16，1： | 1 |
| 17 | Molecularly imprintedpolymer sensor arrays显示文摘 | Greene N T Morgan S L Shimizu K D | 2004 | Chemical Communications2004，，10： | 1 |
| 18 | Surgical correction of tracheo-oesophageal fistula and oesophageal atresia in infants with VACTERL association: a retrospective ease-control study显示文摘 | Morgan RD O'Callaghan JM Wagener S | 2012 | Pediatr Surg Int2012，28，10： | 1 |
| 19 | A Cognitive 'Social Model of Fertility Intentions 显示文摘 | Bachrach C A Morgan S P | 2013 | Population and Development Review2013，，3： | 1 |
| 20 | Biology, eeology and prevalenee of dust mite 显示文摘 | Allan L G Morgan M S | 2003 | Immnuol Allergy Clin N Am2003，23，： | 1 |
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