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| 1 | Brazilin from Caesalpinia sappan heartwood and its pharmacological activities:A review显示文摘Caesalpinia sappan L.(CS) is a plant of Leguminosae family,commonly known as Brazil or Sappan wood.CS is distributed in Southeast Asia and its dried heartwood has been used as traditional ingredient of food or beverages and has a wide variety of medicinal properties.Higher extraction yield of CS wood was achieved with 95% ethanol for 2 h.Chemical constituent's investigation of sappan wood resulled in the isolation of various structural types of phenolic components including one xanihone,one coumarin,three chalcones,two flavones three homoisoflavonoids and brazilin.Brazilin[(6a S-cis)-7,11b-dihydrobcnz[b]indeno[1.2-d]pyran-3.6a.9.10(6H)- tetroll.a major and active compound found in CS heartwood.Most of the folkloric uses of brazilin were validated by the scientific studies such as antioxidant,antibacterial,anti-inflammatory,anti-photoaging.hypoglycemic,vasorelaxant,hepatoproteetive and anti-acne activity.CS heartwood extract is safe and did not produce any acute or subacute toxicity in both male and female rats.Brazilin is the safe natural compound having potential to develop as a medicinal compound with application in food,beverage,cosmetics and pharmaceutical industries to screen its clinical use in modern medicine.The information gained could provide the important and potential approach for pharmaceutical researcher to implicate the knowledge of brazilin in the formulation of new drug and to reveal therapeutic and gaps requiring future research opportunities.More studies are needed to evaluate the potential application of brazilin as preservative and coloring agent in food processing industries. | Nilesh P Nirmal Mithun S Rajput Rangabhatla G.S.V.Prasad Mehraj Ahmad | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，6： | 14 |
| 2 | Predictors of disease severity in ulcerative colitis patients from Southwestern Ontario显示文摘AIM:To understand the demographic characteristics of patients in Southwestern Ontario,Canada with ulcerative colitis(UC)in order to predict disease severity. METHODS:Records from 1996 to 2001 were exam- ined to create a database of UC patients seen in the London Health Sciences Centre South Street Hospital Inflammatory Bowel Disease Clinic.To be included, patients'charts were required to have information of their disease presentation and a minimum of 5 years of follow-up.Charts were reviewed using standardized data collection forms.Disease severity was generated during the chart review process,and non-endoscopic Mayo Score criteria were collected into a composite. RESULTS:One hundred and two consecutive patients'data were entered into the database.Demographic analyses revealed that 51%of the patients were male, the mean age at diagnosis was 39 years,13.7%had a first degree relative with inflammatory bowel disease (IBD),61.8%were nonsmokers and 24.5%were ex-smokers.In 22.5%of patients the disease was limited to the rectum,in 21.6%disease was limited to the sigmoid colon,in 22.5%disease was limited to the left colon,and 32.4%of patients had pancolitis. Standard multiple regression analysis which regressed a composite of physician global assessment of disease severity,average number of bowel movements,and average amount of blood in bowel movements on year of diagnosis and age at time of diagnosis was significant,R 2=0.306,F(7,74)=4.66,P<0.01. Delay from symptoms to diagnosis of UC,gender, family history of IBD,smoking status and disease severity at the time of diagnosis didnot significantly predict the composite measure. CONCLUSION:UC severity is associated with younger age at diagnosis and year of diagnosis in a longitudinal cohort of UC patients,and may identify prognostic UC indicators. | Lee S Roth Nilesh Chande Terry Ponich Maya L Roth James Gregor | 2010 | World Journal of Gastroenterology2010，16，2： | 4 |
| 3 | Assimilation of enterprise systems: The effect of institutional pressures and the mediating role of top management显示文摘 | Liang Huigang Nilesh S Hu Qing | 2007 | MIS Quarterly2007，31，1： | 1 |
| 4 | Acyla- tion of aromatic compounds using moisture insensitive InC13 impregnated mesoporous Si-MCM-41 catalyst显示文摘 | Vasant R Choudhary Suman K Jana Nilesh S Patil | 2002 | Tetrahed- ron Letters2002，43，： | 1 |
| 5 | IS Application Capabilities and Relational Value in Interfirm Partnerships显示文摘 | Nilesh S Christoph S L Gosain S | 2007 | Information Systems Research2007，18，3： | 1 |
| 6 | Application of GPR inthe study of shallow subsurface sedimentary architecture ofModwa spit,Gulf of Kachchh显示文摘 | S B Shukla A K Patidar Nilesh Bhatt | 2008 | Journal of Earth SystemScience2008，117，1： | 1 |
| 7 | Output Feedback Modular Adaptive Control of a Nonlinear Proto Typical Wing Section 显示文摘 | Nilesh B Sahjendra N S | 2004 | Nonlinear Dynamics2004，37，4： | 1 |
| 8 | Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip显示文摘 | Philippa J. Talmud Fotios Drenos Sonia Shah Tina Shah Jutta Palmen Claudio Verzilli Tom R. Gaunt Jacky Pallas Ruth Lovering Kawah Li Juan Pablo Casas Reecha Sofat Meena Kumari Santiago Rodriguez Toby Johnson Stephen J. Newhouse Anna Dominiczak Nilesh J. S | 2009 | The American Journal of Human Genetics2009，，5： | 1 |
| 9 | Angiogenesis-a new target for future therapy显示文摘 | Nilesh M Pandya B Naranjan S | 2006 | Vascular Pharmacology2006，44，5： | 1 |
| 10 | Bone morphogenic protein and its application in trauma cases:a current concept update显示文摘 | Vaibhav B Nilesh P Vikram S Anshul C | 2007 | Injury2007，38，： | 1 |
| 11 | Mechanically improved and optically transparent polycarbonate/clay nanocomposites using phosphonium modified organoclay显示文摘 | Suin S Maiti S Nilesh K | 2014 | Materials and Design2014，54，54： | 1 |
| 12 | Development of electrical conductivity in PP/HDPE/MWCNT nanocomposite by meh mixing at very low loading of MWCNT 显示文摘 | NARENDRA A B NILESH K S SUPRATIM S | 2013 | Polym Compos2013，34，5： | 1 |
| 13 | Decentralized control of web processing lines显示文摘 | Prabhakar R P Nilesh B S Ramamurthy V D | 2007 | IEEE Transactions on Control Systems Technology2007，15，1： | 1 |
| 14 | Angiogenesis: A new target for future therapy 显示文摘 | Nilesh M P Naranjan S D Dev D S | 2006 | Vascular Pharmacology2006，，： | 1 |
| 15 | Two - dimensional fluorescence difference gel electrophoresis for comparative proteomics profiling 显示文摘 | Nilesh S Tannu Scott E Hemby | 2006 | Nat Protoc2006，1，4： | 1 |
| 16 | Chemi- cal, physical, and mechanical characterization of isocyanate cross-linked amine-modified silica aerogels显示文摘 | ATUL K NILESH S SAMIT R | 2006 | Chem Mater2006，18，： | 1 |
| 17 | Antioxidant defense in a lead accumulating plant, Sesbania drummondii显示文摘 | RULEY A T NILESH S C SAHI S V | 2004 | Plant Physiology and Bioc- hemistry2004，42，1： | 1 |
| 18 | Antioxidant defense in a lead accumulating plant, Sesbania drummondii 显示文摘 | RULEY A T NILESH S C SAHI S V | 2004 | Plant Physiol-ogy and Biochemistry^ 20042004，，： | 1 |
| 19 | Is application capabili- ties and relational value in interfirm partnerships 显示文摘 | S NILESH S L CHRISTOPH S GOSAIN | 2007 | Information Systems Research2007，18，3： | 1 |
| 20 | Chemical, physical, and mechanical characterization of isocyanate cross-linked amine-modified silica aerogels显示文摘 | Atul K Nilesh S Samit R | 2006 | Chemistry of Materials2006，18，： | 1 |
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