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| 1 | Immunohistochemical analysis of p53,cyclinD1,RB1,c-fos and N-ras gene expression in hepatocellular carcinoma in Iran显示文摘AIM: To study the effect of some genes especially those involved in cell cycle regulation on hepatocellular carcinoma. METHODS: Paraffin-embedded tissue samples of 25 patients (18 males and 7 females) with hepatocellular carcinoma were collected from 22 pathology centers in Tehran during 2000-2001, and stained using immunohistochemistry method (avidin-biotin-peroxidase) for detection of p53, cyclinD1, RB1, c-fos and N-ras proteins. RESULTS: Six (24%), 5 (20%), 12 (48%) and 2 samples (8%) were positive for p53, cyclinD1, C-fos and N-ras expression, respectively. Twenty-two (88%) samples had alterations in the G1 cell-cycle checkpoint protein expression (RB1 or cyclinD1). P53 positive samples showed a higher (9 times) risk of being positive for RB1 protein than p53 negative samples. Loss of expression of RB1 in association with p53 over-expression was observed in 4 (66.7%) of 6 samples. Loss of expression of RB1 was seen in all cyclinD1 positive, 20 (90.9%) N-ras negative, and 11 (50%) C-fos positive samples, respectively. CyclinD1 positive samples showed a higher (2.85 and 4.75 times) risk of being positive for c-fos and N-ras expression than cyclinD1 negative samples. CONCLUSION: The expression of p53, RB1 and c-fos genes appears to have a key role in the pathogenesis of hepatocellular carcinoma in Iran. Simultaneous overexpression of these genes is significantly associated with their loss of expression during development of hepatocellular carcinoma. | SJ Moghaddam EN Haghighi S Samiee N Shahid AR Keramati S Dadgar MR Zali | 2007 | World Journal of Gastroenterology2007，13，4： | 73 |
| 2 | Endoscopic retrograde cholangiopancreatography outcome from a single referral center in Iran显示文摘BACKGROUND: Endoscopic retrograde cholangiopancreato- graphy (ERCP) is the first choice for diagnostic evaluation of the pancreatic and biliary tree and can be accompanied by a high diagnostic sensitivity and a poor therapeutic outcome. In the current study, we described our experiences in the indications, findings, and technical success of ERCP in a sample of the Iranian population admitted to a referral center in Iran. METHODS: In a retrospective review database-based study, 780 patients (393 males and 387 females; mean age 57.5 years) who had undergone diagnostic and therapeutic ERCP with the primary diagnosis of hepatobiliary disorder between 2006 and 2008 at Taleghani Hospital in Tehran were reviewed. The key data were demographic characteristics, clinical information, laboratory parameters, as well as post-ERCP complications. RESULTS: A history of cholecystectomy was found in about one-third (36.3%) of participants and 80 (10.3%) out of 780 patients had a previous history of biliary stone. A minority (1.4%) of the patients suffered from hepatobiliary carcinomas, and 11 patients had cirrhosis. The most common clinical manifestations in the patients undergoing diagnostic ERCP were icterus (47.3%), weight loss (31.2%), and dark urine (26.9%). Selective biliary cannulation was technically successful in 87.0% of the patients; however, cannulation failed in 13.0%. The most frequent final diagnosis of ERCP was common bile duct stone that was detected in 40.1% of the patients. The ERCP results in 11.0% of the patients were normal. Regarding appropriate treatment, successful stenting was performed in 43 patients (15.2%). Among post-ERCP complications, pancreatitis was the most adverse event withan incidence rate of 3.3%. Other complications including local bleeding, cholangitis and gastrointestinal perforation, rarely occurred. Post-ERCP pancreatitis was reported in 1.8% of men and 3.6% of women (P=0.120). Pancreatitis was more common in women below 70 years than in those who were older than 70 years (3.6% versus 0.5%; OR: 8.216, P=0.015). This might be due to the more functionally active pancreas in younger women than in the older ones. However, other complications were similar in the two age groups. CONCLUSIONS: Based on our experience, ERCP indications, final diagnosis and related complications are comparatively consistent with those reported in other countries. The most common post-ERCP complication is pancreatitis that is more often observed in younger patients. | Amir H Mohammad Alizadeh Esmaeil S Afzali Mirhadi Mousavi Yaghoub Moaddab Mohammad R Zali | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，4： | 3 |
| 3 | Liver,spleen,pancreas and kidney involvement by human fascioliasis:imaging findings显示文摘 | Zali MR Ghaziani T Shahraz S | 2004 | BMC Gastroentero2004，4，： | 1 |
| 4 | Fungal diversity in wounded stems of Aquilaria malaccensis 显示文摘 | Mohamed R Jong P L Zali M S | 2010 | Fungal Divers2010，43，： | 1 |
| 5 | New optimal solutions to disjoint set K-coverage for lifetime extension in wireless sensor networks显示文摘 | Ashouri M Zali Z Mousavi S R et aL | 2012 | IET Wireless Sensor Systems2012，2，1： | 1 |
| 6 | Molecular epidemiology of hepatitis B virus in Iran 显示文摘 | Mohebbi SR Amini-Bavil Olyaee S Zali N | 2008 | Clin Microbiol Infect2008，14，9： | 1 |
| 7 | The Prevalence of Human papillomavirus in cervical cancer in iran显示文摘 | MORTAZAVI S ZALI M RAOUFI M | 2002 | Asian Pac J Cancer Prey2002，3，1： | 1 |
| 8 | Characterization of Plasmodium falciparum isolated from the Amazon region of Brazil: evidence for quinine resistance显示文摘 | Mariano G Zalis Lorrin Pang Mariana S Silveira | 1998 | Am J Trop Med Hyg1998，58，5： | 1 |
| 9 | Time-resolved Emission Spectra and TD-DFT Excited-state Calculations of and 显示文摘 | Farrell I R VanSlageren J Zalis S | 2001 | Inorg Chim Acta2001，315，： | 1 |
| 10 | Human epidermal growth factor receptor-2 family in colorectal adenocarcinoma: Correlation with survival and clinicopathological findings 显示文摘 | Molaei M Pejhan S Nayer BN Moradi A Ghiasi S Zali MR | 2009 | Eur J Gastroenterol Hepatol2009，21，3： | 1 |
| 11 | New optimal solution to disjoint set k-coverage for lifetime extension in wireless sensor networks显示文摘 | Ashouri M Zali Z Mousavi S | 2012 | IET Wireless Sensor Systems2012，2，1： | 1 |
| 12 | The fine structure of rice-starch amylopectin and its relation to the texture of cooked rice 显示文摘 | K R Reddy S ZAli K R Bhattacharya | 1993 | Carbohydrate Polymers1993，22，： | 1 |
| 13 | 显示文摘 | Blanco-Rodriguez A M Ronayne K L Zalis S | 2008 | J Phys Chem A2008，112，16： | 1 |
| 14 | Persistence of microbial contamination on transvaginal ultrasound probes despite Low-Level disinfection procedure显示文摘 | M'zali F Bounizra C Leroy S | 2014 | PLoS One2014，9，93： | 1 |
| 15 | Evaluation of genotype x environment interaction in chickpea using meas- ures of stability from AMMI model显示文摘 | Zali H Farshadfar E Sabaghpour S H | 2012 | Ann Biol Res2012，3，7： | 1 |
| 16 | Fungal diversity in wounded stems of Aquilaria malaccensis 显示文摘 | MOHAMED R JONG P L ZALI M S | 2010 | Fungal Di- vers2010，43，1： | 1 |
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