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| 1 | Effectiveness of rotavirus vaccines against rotavirus infection and hospitalization in Latin America: systematic review and metaanalysis显示文摘Background:Rotavirus was the leading cause of childhood diarrhoea-related hospitalisations and death before the introduction of rotavirus vaccines.Methods:We describe the effectiveness of rotavirus vaccines to prevent rotavirus infections and hospitalizations and the main rotavirus strains circulating before and after vaccine introduction through a systematic review and meta-analysis of studies published between 1990 and 2014.203 studies were included to estimate the proportion of infections due to rotavirus and 10 to assess the impact of the vaccines.41 of 46 studies in the post-vaccination period were used for meta-analysis of genotypes,20 to calculate VE against infection,eight for VE against hospitalisation and seven for VE against severe rotavirus-diarrhoea.Results:24.3%(95%CI 22.1–26.5)and 16.1%(95%CI 13.2–19.3)of cases of diarrhoea were due to rotavirus before and after vaccine introduction,respectively.The most prevalent G types after vaccine introduction were G2(51.6%,95%CI 38–65),G9(14.5%,95%CI 7–23)and G1(14.2%,95%CI 7–23);while the most prevalent P types were P[4](54.1%,95%CI 41–67)and P[8](33%,95%CI 22–46).G2P[4]was the most frequent genotype combination after vaccine introduction.Effectiveness was 53%(95%CI 46–60)against infection,73%(95%CI,66–78)against hospitalisation and 74%(95%CI,68.0–78.0)against severe diarrhoea.Reductions in hospitalisations and mortality due to diarrhoea were observed in countries that adopted universal rotavirus vaccination.Conclusions:Rotavirus vaccines are effective in preventing rotavirus-diarrhoea in children in Latin America.The vaccines were associated with changes in genotype distribution. | Victor S.Santos Daniella P.Marques Paulo R.S.Martins-Filho Luis E.Cuevas Ricardo Q.Gurgel | 2016 | Infectious Diseases of Poverty2016，5，1： | 7 |
| 2 | Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells显示文摘Colorectal cancer(CRC)represents the third most commonly diagnosed cancer and the second leading cause of cancer death worldwide.The modern concept of cancer biology indicates that cancer is formed of a small population of cells called cancer stem cells(CSCs),which present both pluripotency and self-renewal properties.These cells are considered responsible for the progression of the disease,recurrence and tumor resistance.Interestingly,some cell signaling pathways participate in CRC survival,proliferation,and selfrenewal properties,and most of them are dysregulated in CSCs,including the Wingless(Wnt)/β-catenin,Notch,Hedgehog,nuclear factor kappa B(NF-κB),Janus kinase/signal transducer and activator of transcription(JAK/STAT),peroxisome proliferator-activated receptor(PPAR),phosphatidyl-inositol-3-kinase/Akt/mechanistic target of rapamycin(PI3K/Akt/mTOR),and transforming growth factor-β(TGF-β)/Smad pathways.In this review,we summarize the strategies for eradicating CRC stem cells by modulating these dysregulated pathways,which will contribute to the study of potential therapeutic schemes,combining conventional drugs with CSC-targeting drugs,and allowing better cure rates in anti-CRC therapy. | Valdenizia R.Silva Luciano de S.Santos Rosane B.Dias Claudio A.Quadros Daniel P.Bezerra | 2021 | Cancer Communications2021，41，12： | 3 |
| 3 | Genetic divergence in the Atlantic–Mediterranean Montagu’s blenny, Coryphoblennius galerita (Linnaeus 1758) revealed by molecular and morphological characters显示文摘 | VERA S.DOMINGUES CLáUDIAFARIA SERGIOSTEFANNI RICARDO S.SANTOS ALBERTOBRITO VITOR C.ALMADA | 2007 | Molecular Ecology2007，，17： | 1 |
| 4 | Nonsurgical treatment of extensive cyst‐like periapical lesion of endodontic origin显示文摘 | J.Soares S.Santos F.Silveira E.Nunes | 2006 | International Endodontic Journal2006，，7： | 1 |
| 5 | Pain and quality of life in leprosy patients in an endemic area of Northeast Brazil:a cross-sectional study显示文摘Background:Pain emerges as a challenge in the treatment of leprosy patients.In this study,we describe the prevalence and type of pain in patients with leprosy,and its effect on patients’quality of life in an endemic area of Northeast Brazil.Findings:A cross-sectional survey of 260 patients attending leprosy reference centres in Sergipe,Northeast Brazil was conducted.Individuals were assessed for the presence and type of pain,skin sensory loss,peripheral nerve enlargement,touch and pinprick sensations,mechanical allodynia and nerve palpation.Participants completed the Douleur Neuropathique 4 questionnaire,and we also used the Brief Pain Inventory scale and the World Health Organization Quality of Life-BREF instrument to arrive at our results.One hundred and ninety-five(75%)patients reported pain,mostly of the neuropathic type.Pain was moderate in 84(43.1%)and severe in 94(48.2%)participants.The presence of pain was associated with disability(p=0.001),leprosy reactions(p=0.004)and lower quality of life.Most patients with neuropathic pain were treated with steroids,despite their low efficacy for this type of pain.Conclusion:Pain is highly prevalent among leprosy patients and is associated with low quality of life.Leprosy management should include a systematic assessment of the type of pain a patient experiences in order to provide adequate treatment. | Victor S.Santos Jamilly C.V.Santana Fabrícia D.N.Castro Laudice S.Oliveira Julianne C.V.Santana Vera L.C.Feitosa Ricardo Q.Gurgel Luis E.Cuevas | 2016 | Infectious Diseases of Poverty2016，5，1： | 1 |
| 6 | Mapping uncovered a multi-phase arc-back-arc system in the southern Beishan during the Permian显示文摘The Central Asian orogenic belt(CAOB),surrounded by the Baltica and Siberia cratons to the north,and the Tarim and North China cratons to the south,records successive evolution cycles of subduction and accretion/collision from Neoproterozoic to the Paleozoic that consumed and eventually closed the Paleo-Asian Ocean[1].Tectonic models of the terminal orogenesis are contentious,with discussions ranging from the time and location of final closure of the Paleo-Asian Ocean to the regional context and setting of its various tectonic constituents. | Tong Hong Gabriel S.Santos Cees Rvan Staal Wenhua Ji Shoufa Lin | 2023 | National Science Review2023，10，2： | 0 |
| 7 | A critical review towards the causes of the iron-based catalysts deactivation mechanisms in the selective oxidation of hydrogen sulfide to elemental sulfur from biogas显示文摘Hydrogen sulfide(H_(2)S) not only presents significant environmental concerns but also induces severe corrosion in industrial equipment,even at low concentrations.Among various technologies,the selective oxidation of hydrogen sulfide(SOH_(2)S) to elemental sulfur(S) has emerged as a sustainable and environmentally friendly solution.Due to its unique properties,iron oxide has been extensively investigated as a catalyst for SOH_(2)S;however,rapid deactivation has remained a significant drawback.The causes of iron oxide-based catalysts deactivation mechanisms in SOH_(2)S,including sulfur or sulfate deposition,the transformation of iron species,sintering and excessive oxygen vacancy formation,and active site loss,are thoroughly examined in this review.By focusing on the deactivation mechanisms,this review aims to provide valuable insights into enhancing the stability and efficiency of iron-based catalysts for SOH_(2)S. | Mostafa Tarek Janaina S.Santos Victor Márquez Mohammad Fereidooni Mohammad Yazdanpanah Supareak Praserthdam Piyasan Praserthdam | 2024 | Journal of Energy Chemistry2024，90，3： | 0 |
| 8 | 靶向信号通路杀伤结直肠癌干细胞的新型药物显示文摘在全球范围内,结直肠癌(colorectal cancer,CRC)是第三大最常见的癌症,也是第二大致死的癌症。目前癌症生物学认为,癌是由一小群肿瘤干细胞(cancer stem cells,CSCs)形成,CSCs具有多潜能和自我更新的特性。CSCs被认为是与肿瘤发展、复发和耐药性有关。有趣的是,一些细胞信号通路参与维持CRC的存活、增殖和自我更新的特性,其中大多数信号通路在CSCs中被异常调控,这些通路包括Wnt(Wingless)/β-catenin、Notch、Hedgehog、NF-κB(nuclear factor kappa B)、JAK/STAT(Janus kinase/signal transducer and activator of transcription)、PPAR(peroxisome proliferator-activated receptor)、PI3K/Akt/mTOR(phosphatidyl-inositol-3-kinase/Akt/mechanistic target of rapamycin)和TGF-β(transforming growth factor-β)/Smad信号通路。在本综述中,我们总结了当前通过调控使这些异常信号通路来杀伤CRC干细胞的策略,这将有可能探索出联合常规药物和CSCs靶向药物的治疗方案,并将有助于提高CRC的治愈率。 | Valdenizia R.Silva Luciano de S.Santos Rosane B.Dias Claudio A.Quadros Daniel P.Bezerra | 2023 | 癌症2023，42，4： | 0 |
| 9 | High-throughput phenotyping by applying digital morphometrics and fluorescence induction curves in seeds to identifying variations:A case study of Annona(Annonaceae)species显示文摘Differences in physical and structural characteristics of seeds may indicate variability within and between plant populations.In the present study,we performed a close characterization of dimension,shape,and tegument delayed chlorophyll fluorescence in seeds obtained from three species of the genus Annona(Annonaceae),i.e.,Annona coriacea,A.montana,A.squamosa.Results showed that studied seeds may be sorted as scalene ellipsoids expressing low values for the seed sphericity.The morphological estimates suggested differences in seed shape for all species.A high correlation was observed between surface area and volume(r^2>99%)for all the three species suggesting that in addition to structural shape.In addition,we also observed very high positive correlations(Rho=1.000,p<0.001)between surface area and arithmetic mean diameterof the seeds for all species.The first principal component(PCA1)of elliptical Fourier descriptors explained most of the variations in morphological structure of the seeds in the three species.Additionally,a less intense tegument delayed chlorophyll fluorescence was observed for A.montana while the highest intensity was recorded for A.squamosa,revealing the potential use of fluorescence spectroscopy in discrimination at the species level by analyzing the frequency domain by means of Fourier Transform spectra as well as the relationship time-frequency of chlorophyll fluorescence. | Montcharles S.Pontes Carlos V.Montefusco-Pereira Biswapriya B.Misra Howard L.Ribeiro-Junior Daniela E.Graciano Jaqueline S.Santos Michele A.S.Nobrega Shaline S.L.Fernandes Anderson R.L.Caires Etenaldo F.Santiago | 2018 | Information Processing in Agriculture2018，5，4： | 0 |
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