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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 4 | Hints on test data selection help for the practicing programmer 显示文摘 | DeMILLO R A LIPTON R J SA YWARD F G | 1978 | Computer1978，11，4： | 1 |
| 5 | , Purification and partial characterizeation of Chickpea 2S albumin显示文摘 | Sa nchez-Vioque R Mille n F Clemente A | 1999 | Journal of Agriculture and Food Chemistry1999，47，： | 1 |
| 6 | Treatment of infertility in women with polycystic ovary syndrome 显示文摘 | Santana L F Ferriani R A Sa M F | 2008 | Rev Bras Ginecol Obstet2008，30，4： | 1 |
| 7 | Human papillomavirus is associated with breast cancer in the north part of Iran显示文摘 | Sigaroodi A Nadji SA Naghshvar F | 2012 | Sci World J2012，，83： | 1 |
| 8 | Sirolimus, a new, potent immunosuppressive agent 显示文摘 | KELLY P A GRUBER SA BEHBOD F | 1997 | Pharmacotherapy1997，17，6： | 1 |
| 9 | Development of chemiluminescent ELISAs to DDT and its metabolites in food and environmental samples 显示文摘 | Botchkareva AE Eremin SA Montoya A Manclús JJ Mickova B Rauch P Fini F Girotti S | 2003 | J Immunol Methods2003，283，1： | 1 |
| 10 | Effect of topical povi- done-iodine versus topical ofloxacin on experimental Staphylo- coccus keratitis Graefes显示文摘 | Melki SA Safar A Yaghouti F | 2000 | Arch Clin Exp Ophthalmol2000，238，5： | 1 |
| 11 | Loealisation of enzymes in the digestive system during early development of the grouper ( Epinephelus coioides) 显示文摘 | Quinitio G F Sa - an A C Toledo J D | 2004 | Advances in grouper aquaculture2004，1，： | 1 |
| 12 | Performance of the GenoType MTBDR plus assay directly on sputum speci- mens from Brazilian patients with tuberculosis treatment failure or relapse显示文摘 | Maschmann Rdc A Sa Spies F Nunes Lde S | 2013 | J Clin Microbiol2013，51，5： | 1 |
| 13 | Evaluation of ovarian adhesion formation after laparoscopic ovarian drilling by second - look minilaparoscopy 显示文摘 | Mercorio F Mercorio A Di Spiezio SA | 2008 | Fertil Steril2008，89，5： | 1 |
| 14 | Development of a rapid and sensitive LC-ESI/MS/MS assay for the quantification of propofol using a simple off-line dansyl chloride derivatization reaction to enhance signal intensity显示文摘 | Beaudry F Guenette SA Winterborn A | 2005 | J Pharm Biomed Anal2005，39，： | 1 |
| 15 | 高血压高危患者的去肾交感神经术治疗显示文摘去肾交感神经术(renal denervation,RDN)治疗难治性高血压的研究正在进行中,对于心血管病风险较高的患者来说,RDN可能是一种具有吸引力的治疗方法。确定基线心血管病风险是否会影响RDN的有效性非常重要。该项研究的目的是评估伴有各种合并症的患者RDN后的血压降低和事件发生率,并验证RDN在这些高风险人群中有效且持久这一假设。 | 刘青(译) 刘莉(校) Mahfoud F Mancia G Schmieder R Narkiewicz K Ruilope L Schlaich M Whitbourn R Zirlik A Zeller T Stawowy P Cohen SA Fahy M Bohm M | 2020 | 中华高血压杂志2020，28，8： | 1 |
| 16 | Bio-inspired Sensor Fusion for Quality Assessment of Harumanis Mangoes显示文摘 | Sa’ad F S A Zakaria A Shakaff A Y M | 2012 | Procedia Chemistry2012，6，： | 1 |
| 17 | Heterologous expression of a gene for thermostable xylanase from Chaetomium thermophilum in Pichia pastoris GSI15 显示文摘 | Ghaffar A Khan SA Mukhtar Z Rajoka MI Latif F | 2011 | Mol Bioi Rep2011，38，5： | 1 |
| 18 | Incorporation of NKT cell-activating glycolipids enhances immunogenicity and vaccine efficacy of Mycobacterium bovis bacillus Calmette-Guerin显示文摘 | Venkataswamy MM Baena A Goldberg MF Bricard G Im JS Chan J Reddington F Besra GS Jacobs WR Jr Porcelli SA | 2009 | J Immnnol2009，183，3： | 1 |
| 19 | Effects of modified and classic Blalock -Taussig shunts on the pulmonary arterial tree显示文摘 | Godart F Qureshi SA Simha A | 1998 | Ann Thorac Surg1998，66，2： | 1 |
| 20 | Arabidopsis phosphoenolpyruvate carboxylase genes encode immunologically unrelated polypeptides and are differentially expressed in response to drought and salt stress 显示文摘 | Sa' R Flores A Cejudo F J | 2006 | Planta2006，223，： | 1 |
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